Treatment of vitiligo with khellin liposomes, ultraviolet light and blister roof transplantation

Abstract

Seventy-five percent of the patients were satisfied with the cosmetic result. All of the patients would recommend the treatment to other vitiligo patients. More than 75% re-pigmentation of the vitiligo areas was noted in 47% of the patients according to the blinded evaluation of photographs taken before and after the treatment.

QUALITATIVE AND QUANTITATIVE ANALYSIS OF KHELLIN IN AMMI VISNAGA FRUITS AND PHARMACEUTICAL PREPARATIONS USING HPTLC AND HPLC

“…It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. [3][4][5][6] Other pharmacological effects of khellin includes prevention of renal crystal deposition in hyperoxaluric rats, prevention of cell damage caused by oxalate in renal epithelial cells, and hypocholesterolemic effect. [7][8][9] A thorough literature survey has revealed that a limited number of spectrophotometric, fluorimetric, voltametric, electrophoretic, and chromatographic methods have been reported for analysis of khellin.…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Several chromone derivatives have been reported for their clinical use as therapeutic agents. For example, khellin ( Figure 6), a natural product extracted from the seeds of the plant Ammi visnaga, was the first chromone-based therapy mainly used for centuries in the Mediterranean medicine as a diuretic, relaxant and also in the treatment of angina, asthma and vitiligo, a melanoma-driven pigmentation [92][93][94]. Daflon ® (diosmin) is a venotropic drug used in the treatment of venous diseases and hemorrhoids, while Lomudal ® (sodium cromoglycate) is clinically used for the treatment of asthma and allergies ( Figure 6) [95,96].…”

“…It also found in fruits (e.g., bilberry, cloudberry), green tea and other foods such as chicory. Coumarin derivatives possess a remarkable range of biological properties including antioxidant [109,110], vasorelaxant [111], antiviral (92,93) [112,113], anti-cancer (94,95), and anti-inflammatory activities [114,115]. Lastly, suksdorfin (96), another natural compound isolated from the fruit of Lomatium suksdorfii, exhibits a significant anti-HIV activity as it inhibits the viral replication in the T-cell line with an EC50 in the 2.5 µM range [116] (Figure 8).…”

Photochemical studies: Chromones, bischromones and anthraquinone derivatives

“…The various activities associated with chromones include antioxidant (Gomes et al, 2009;Shanthi et al, 2013;Phosrithong et al, 2012), anti-inflammatory (Khadem and Marles, 2012;Deshmukh et al, 2009), antiulcer (Lemos et al, 2012, biocidal (Sharma et al, 2011), wound healing (Hajhashemi et al, 2012), immune stimulatory, (GamalEldeen et al, 2007) etc. Khelin 1 was the first chromone extracted from Ammi visnaga, used as a diuretic to relieve renal colic (Edwards and Howell, 2000), as a smooth muscle relaxant (Nordlund, 2006) and in the treatment of vitiligo, a pigmentation disorder (De Leeuw et al, 2011). Other chromone derivatives for example sodium cromoglycate 2, diosmin 3 and flavoxate 4 are used as a mast cell stabilizer in allergic asthma and allergic conjunctivitis, for the treatment of various diseases and as a smooth muscle relaxant to treat urge incontinence (Holgate and Polosao, 2008;Frick, 2000;Ruffmann, 1988).…”