Treatment of Vitreous Hemorrhage in Rh-Positive Patients by Intravitreal Injection of Anti-Rh₀- Immunoglobulin

Abstract

22 Rh-positive patients suffering from vitreous hemorrhage caused by injuries to the eye, hypertension, or associated with subarachnoid hemorrhage, were treated with anti-Rh-immunoglobulin by intravitreal injection. 8 patients (36.4%) needed only one immunoglobulin injection and rapidly regained their former visual acuity. In 2 cases with repeated hemorrhage the result of the treatment was not satisfactory. The incidence of adverse effects was low.

Tolerance of Intravitreous lnterleukin-1 β in the Treatment of Experimental Vitreous Hemorrhage

“…It has been suggested that treatment must be di rected toward the improvement o f physiolog ic mechanisms o f clot removal such as inflam Supported mation [2] by stimulating fibrynolysis or phagocytosis [4]. Interleukin-1 (IL-1 ) has been reported to cause intraocular inflammation when injected into the vitreous cavity [5,6], In a previous study [7], we reported that low doses o f natural human IL -1 injected intravitreally enhance the spontaneous reab-sorption o f experimental vitreous hemor rhages with no apparent effect on the intra ocular structures.…”