Treatment of Wilms Tumor: A Report from the Turkish Pediatric Oncology Group (TPOG)

Akyüz, Canan; Yalçın, Bilgehan; Yıldız, İnci; Hazar, Volkan; Yoruk, Asim; Tokuç, Gülnur; Akıcı, Ferhan; Büyükpamukçu, Nebìl; Kale, Gülsev; Atahan, Lale; Büyükünal, Cenk; Dervışoğlu, Sergülen; Atkovar, Gülyüz; Melikoğlu, Mustafa; Karpuzoğlu, Gülten; Olgun, Nur; Ayan, İnci̇; Oğuz, Aynur; Yarış, Nilgün; Dağdemir, Ayhan; Darendeliler, Emin; Sander, Serdar; Kuyumcuoğlu, Uğur; Ozseker, Naciye; Çorapçıoğlu, Funda; Tanyeli, Atilla; Düzovalı, Öznur; Aydın, G. Burça; Büyükpamukçu, Münevver

doi:10.1016/j.jpurol.2010.02.104

Cited by 7 publications

(10 citation statements)

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“…It is quite rare in the children under six months and older than 10 years 5 . Although Wilms tumour is seen in both genders at almost the same rate, female/male ratio was 2 in our study similar to other series reported by Akyüz et al and Israels et al 6,7 . Many of the children with Wilms tumour apply with abdominal mass that can be palped by family members or doctors during the physical examination.…”

Section: Discussionsupporting

confidence: 90%

“…However, OS time was significantly shorter in Syrian patients. In another study from our country by Akyüz et al, a better survival rate was reported with TPOG protocol 6 . The stage, the existence of anaplasia and the status of distant metastasis were the factors that affect the survival rate negatively in our study.…”

Section: Discussionmentioning

confidence: 68%

“…The patients were treated in our hospital according to the protocol of Turkish Pediatric Oncology Group (TPOG) protocol 6 . NC included vincristine (1.4mg/m 2 ) for four weeks and actinomycin-d (15 microgram/kg) given for 5 days.…”

Section: Methodsmentioning

confidence: 99%

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Treatment results of Wilms tumour

Cesur¹,

Küpeli

Özçelik

2019

Cukurova Medical Journal

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The purpose of this study was to evaluate the treatment results of the patients with Wilms tumour (WT). Materials and Methods: The clinical records of 21 children with WT treated between 2012 and 2017 were retrospectively reviewed. Age, nationality, symptoms, diagnostic and surgical methods, surgical complications, the stage of the disease, the status of neoadjuvant chemotherapy, radiotherapy status, presence of recurrent disease and histopathological characteristics of the tumour and outcome of the patients were analyzed. Results: The female/male ratio was 2/1 and the mean age was 4.21±2.26 years. The most common physical examination finding was abdominal mass. The diagnosis was made with clinical examination and radiological investigation in 90.5% of the patients. Total nephroureterectomy was performed in all patients. The most common histopathological subgroup was classical Wilms Tumour that was detected in 81 % of the patients. 6.8 % of the patients had distant metastasis at the time of the diagnosis. The most common distant metastasis site was lungs. Overall survival (OS) of the patients was 85.7% and mean survival time was 36 months (2 months-62 months). Advanced stage at diagnosis, presence of distant metastasis and diffuse anaplastic histology were associated with worse OS rates. Conclusion: Similar to existing knowledge on outcome of patients with Wilms tumor, our results confirmed the negative effect of advanced stage, distant metastasis and diffuse anaplastic histology on survival. Further large-scale studies investigating molecular features of the tumor are needed to decide for proper treatment and to better predict outcome. Amaç: Bu çalişmanın amacı Wilms tümörlü (WT) hastaların tedavi sonuçlarını değerlendirmektir. Gereç ve Yöntem: 2012-2017 yılları arasında WT tanılı 21 hastanın klinik kayıtları geriye dönük olarak incelendi. Yaş, uyruk, semptomlar, teşhis ve cerrahi methotlar, cerrahi komplikasyonlar, hastalığın evresi, neoadjuvan kemoterapi durumu, radyoterapi durumu, rekürren hastalığın varlığı, tümörün histopatolojik özellikleri ve hastaların sonuçları analiz edildi. Bulgular: Kız/erkek oranı 2/1olup, ortalama yaş 4.21±2.26 yıldı. En sık saptanan fizik muayene bulgusu abdominal kitle idi. Hastaların %90,5'ine radyolojik bulgular ve klinik muayene ile tanı konuldu. Hastaların tamamına total nefroüreterektomi uygulandı. Hastaların %81'inde saptanan histopatolojik alt grup klasik Wilms tümörü idi. Hastaların %6,8'inde tanı anında uzak metastaz olup en sık uzak metastaz yeri akciğerdi. Hastaların genel sağkalımı (OS) %85,7 idi ve ortalama sağkalım süresi 36 aydı(2 ay-62 ay). Tanı anında ileri ever hastalık olması, uzak metastaz varlığı ve difüz anaplastik histoloji ile sağkalım oranları belirgin olarak etkilenmekteydi. Sonuç: Literatürdeki verilere benzer şekilde, çalışmamızın bulguları Wilms tümöründe ileri evre, uzak metastaz ve yaygın anaplastik histolojinin sağkalım üzerindeki olumsuz etkilerini doğrulamıştır. Uygun tedaviye karar vermek ve prognozu daha kesin olarak belirleyebilmek için tümörü...

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 68%

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Treatment results of Wilms tumour

Cesur¹,

Küpeli

Özçelik

2019

Cukurova Medical Journal

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“…Our patients were treated in line with the TPOG system . Actinomycin‐D containing protocols have been routinely used by pediatric oncologists in patients newly diagnosed with WT in Turkey.…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological classification and clinical staging were performed on the basis of the Turkish Pediatric Oncology Group (TPOG) system . Clinical records were surveyed for all patients, and data including age, gender, and symptoms at presentation, sites of initial involvement, laboratory results, initial treatment, therapeutic response and date of diagnosis, date of first treatment, date of relapse, date of death or last follow‐up were collected.…”

Section: Methodsmentioning

confidence: 99%