Treatment of Xanthoma Disseminatum With Narrowband UV-B Phototherapy

Martínez, Marta García-Legaz; Martínez‐Doménech, Álvaro; Magdaleno‐Tapial, Jorge; Valenzuela‐Oñate, Cristian; Iborra-Palau, Elena Violeta; Miquel, Víctor Alegre de; Pérez‐Ferriols, A.

doi:10.1001/jamadermatol.2020.4092

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…However, there can be severe adverse effects, such as myelosuppression, and there is a lack of sufficient data in its use in children. Recently, a XD patient with facial involvement has been successfully treated with narrowband UV‐B phototherapy 11 …”

Section: Discussionmentioning

confidence: 99%

Eruptive papules on axillary folds of an adolescent

Bartolomeo

Pomi

Vaccaro

et al. 2023

Pediatric Dermatology

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A 16-year-old female presented with a 3-week history of an asymptomatic papular eruption in her axillae with progressive increase in the number of lesions. The patient had no systemic symptoms.Personal and familial history was negative for cutaneous diseases.Examination revealed discreet and grouped yellow-red papules symmetrically in the axillae (Figure 1). Mucous membranes were not involved. Dermoscopy showed an orange-yellow background with an erythematous or brown rim. Some lesions had telangiectatic vessels and whitish globules (Figure 2, red arrows) and were crossed by white rail lines (Figure 2, asterisk). A biopsy was performed (Figure 3).

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Section: Discussionmentioning

confidence: 99%

Eruptive papules on axillary folds of an adolescent

Bartolomeo

Pomi

Vaccaro

et al. 2023

Pediatric Dermatology

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“…Langerhans cells depletion has been described with UVB and UVA, 4 and both therapies have been successfully used in some individuals with group L and C histiocytosis (Table 1). 5–10 Due to the presence of deep nodules in our patient, we decided to try PUVA therapy.…”

Section: Discussionmentioning

confidence: 99%

“…with group L and C histiocytosis (Table 1). [5][6][7][8][9][10] Due to the presence of deep nodules in our patient, we decided to try PUVA therapy.…”

Section: Con Clus Ionsmentioning

confidence: 99%

PUVA therapy in persistent cutaneous histiocytosis: Case report and literature review

Taibo

Loureiro

Almagro

et al. 2022

Photoderm Photoimm Photomed

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Background: Cutaneous and mucocutaneous histiocytosis (group C) comprise a wide variety of entities affecting skin and/or mucosae. Although they are considered as reactive proliferations, their exact pathophysiology remains unknown and, therefore, they lack a specific treatment. Aims:The aim of this study is to review the evidence on cases of histiocytosis treated with UVB and/or UVA and to report a new case of relapsing group C histiocytosis that has been successfully treated with PUVA therapy. Materials & Methods:We have conducted a review of the literature published over the last 40 years on the treatment of histiocytosis with phototherapy in the online PubMed database. We also describe a new case of successful treatment of histiocytosis with PUVA therapy. Results:Our patient was a 27-year-old man with persistent outbreaks of cutaneous histiocytosis over the previous 8 years. He responded successfully to PUVA therapy, and no relapse has been detected after one year of follow-up. Discussion: Self-involution is usual in group C histiocytosis, so conservative management is usually the first approach. Relapsing cases pose a therapeutic challenge.Reported treatment options for these patients include isotretinoin, cryotherapy, immunosuppressants, low-dose chemotherapy, CO2 laser, radiotherapy, and surgery.Phototherapy and photochemotherapy have been used in a small number of patients with considerable success. The main limitation to provide firm recommendations on histiocytosis therapy is the absence of solid evidence, as the articles published are mainly case reports with a short follow-up. In our patient, despite the short follow-up we have considered photochemotherapy to be effective since no spontaneous remission had been achieved in the previous 8 years. Conclusion:PUVA therapy could be a safe and effective option to treat persistent cutaneous manifestations in patients with histiocytosis, although more evidence is required to support this statement.

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“…In the Research Letter entitled “Treatment of Xanthoma Disseminatum With Narrowband UV-B Phototherapy,” the first author’s surname was listed as “Martínez” but should be “García-Legaz Martínez.” This article was corrected online.…”

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confidence: 99%

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2021

JAMA Dermatol

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Treatment of Xanthoma Disseminatum With Narrowband UV-B Phototherapy

Cited by 3 publications

References 6 publications

Eruptive papules on axillary folds of an adolescent

Eruptive papules on axillary folds of an adolescent

PUVA therapy in persistent cutaneous histiocytosis: Case report and literature review

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