Treatment of young rats with cholestyramine or a hypercholesterolemic diet does not influence the response of serum cholesterol to dietary cholesterol in later life

Beynen, A.C.; Bruijne, J.J. de; Katan, Martijn B.

doi:10.1016/0021-9150(85)90062-0

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…This is normal in rats, and has been described in common laboratory strains such as the Wistar rat [21] and the Sprague-Dawley rat [22]. The fact that this decrease did not occur in the FHH rats can be attributed to an increase in cholesterol secondary to proteinuria, be cause cholesterol and apolipoprotein levels were lowered to values similar to those found in FHL when proteinuria in FHH was prevented by lisinopril.…”

Section: Discussionmentioning

confidence: 82%

Hyperlipidemia Is Secondary to Proteinuria and Is Completely Normalized by Angiotensin-Converting Enzyme Inhibition in Hypertensive Fawn-Hooded Rats

Verseput

Provoost

Tol

et al. 1997

Nephron

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Two substrains of the fawn-hooded (FH) rat have been developed, one of which develops progressive hypertension and proteinuria, the FHH, and one which shows little increase in blood pressure and no renal damage, the FHL. Other hypertensive rodent models show primary metabolic disturbances before the development of renal damage, notably hypertriglyceridemia, which may also contribute to progression of renal disease. In this study we evaluated whether hyperlipidemia is a primary disturbance in FHH, or only occurs secondary to proteinuria. Lipid levels were determined before and after development of proteinuria, and compared to those found in age-matched FHL. We also determined whether reducing proteinuria with lisinopril would normalize lipid levels in aging FHH. At 4 weeks of age, proteinuria was very low (2-3 mg/day) in both FHH and FHL. While proteinuria increased steadily in aging FHH, reaching 350 ± 62 mg/day at 40 weeks, much less increase was observed in FHL over the same period (32 ± 5 mg/day at 40 weeks). Blood pressure was markedly higher in adult FHH than in FHL (158 ± 2 vs. 129 ± 2 mm Hg, p < 0.01). In 4-week-old FHL and FHH, plasma cholesterol levels were similar. Subsequently, cholesterol increased in FHH, reaching 3.4 ± 0.9 mmol/l at 40 weeks, whereas cholesterol was barely affected by aging in FHL (2.1 ± 0.2 mmol/l at 40 weeks). At 4 weeks, triglyceride levels were lowest in FHH. Subsequently, triglycerides increased in FHH, reaching 3.5 ± 1.5 mmol/l at 40 weeks, as compared to 1.3 ± 0.2 mmol/l in FHL. Besides a transient increase in triglyerides in lisinopril-treated FHH at 11 weeks, increments in blood pressure, proteinuria, cholesterol, triglycerides and apolipoproteins A-I, B and E aging FHH were effectively prevented by lisinopril. These data strongly suggest that there is no primary difference in lipid metabolism between FHH and FHL and that changes in plasma lipids in FHH as compared to FHL are all secondary to proteinuria.

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Section: Discussionmentioning

confidence: 82%

Hyperlipidemia Is Secondary to Proteinuria and Is Completely Normalized by Angiotensin-Converting Enzyme Inhibition in Hypertensive Fawn-Hooded Rats

Verseput

Provoost

Tol

et al. 1997

Nephron

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“…when the animals were challenged with dietary cholesterol, the in crease in serum cholesterol was less in pre treated animals than the ones that had not been pretreated [Reiser, 1971;Reiser and Sidelman, 1972], This has not been con firmed in other studies on rats [Kris-Etherton et al, 1979;Hulbron et al. 1982;Green et al, 1981;Beynen et al, 1985]. However, low response has been found in the guinea pig after stimulating cholesterol catabolism with cholestyramine in the neonatal period [Li et al, 1979[Li et al, , 1980Hassan et al.…”

mentioning

confidence: 70%

Dietary Cholesterol and Fats at a Young Age: Do They Influence Cholesterol Metabolism in Adult Life?

Temmerman¹,

Vonk²,

Niezen-Koning³

et al. 1989

Ann Nutr Metab

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The effects of dietary cholesterol and fats on cholesterol metabolism later in life were studied in Mongolian gerbils. Three groups were given a basic diet with soybean oil, palm kernel oil amounting to 8.75% (w/w), or the basic diet only. In three other groups, cholesterol (0.05 %) was added to the above diets. Measurements were done in animals of the third generation on the diets. On all diets, the serum cholesterol of the sucklings was increased as compared to the young that were suckled by mothers on the basic diet only, while body cholesterol was highest in sucklings of mothers on the basic diet or palm-kernel-oil-enriched diets. When the diets were replaced by the basic diets at 6 months of age, serum cholesterol was still increased at 12 months of age in animals previously fed on the cholesterol-enriched diets. Tissue cholesterol did not differ. However, after a challenge with cholesterol at that age, the differences in serum cholesterol were not significantly different.

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“…On these diets rats develop hepatomegaly and show increased activities of indicator enzymes for liver function such as alanine aminotransferase and aspartate aminotransferase (Beynen, De Bruijne et al, 1985). Histopathological investigation of the livers revealed marked lipidosis of hepatocytes, bile duct and oval cell proliferation, and fibrosis (Beynen, Danse et aI., 1985).…”

Section: Received 30 October 1987 Accepted 4 March 1988mentioning

confidence: 99%

Assessment of discomfort in rats with hepatomegaly

Beynen¹,

Baumans

Bertens

et al. 1988

Lab Anim

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SummaryAn attempt was made to assess discomfort in rats with hepatomegaly induced by feeding a high cholesterol, high cholate diet. After 8 weeks, the rats displayed a more than two-fold increase in liver weight when compared with controls fed a commercial diet. In a small open field test, behaviour of rats with hepatomegaly was similar to the controls. Of 9 parameters scored per rat, only the response to pressure on the right hypochondrium (tension of overlying muscles) scored higher than in control animals. There was considerable between-assessor variation in the assignment of scores. It is suggested, tentatively, that hepatomegaly in rats caused by cholesterol plus cholate feeding, may not cause extreme discomfort. Upon 'blind' palpation of control and test rats, an average of 60% of the rats with hepatomegaly were classified correctly.

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Treatment of young rats with cholestyramine or a hypercholesterolemic diet does not influence the response of serum cholesterol to dietary cholesterol in later life

Cited by 14 publications

References 19 publications

Hyperlipidemia Is Secondary to Proteinuria and Is Completely Normalized by Angiotensin-Converting Enzyme Inhibition in Hypertensive Fawn-Hooded Rats

Hyperlipidemia Is Secondary to Proteinuria and Is Completely Normalized by Angiotensin-Converting Enzyme Inhibition in Hypertensive Fawn-Hooded Rats

Dietary Cholesterol and Fats at a Young Age: Do They Influence Cholesterol Metabolism in Adult Life?

Assessment of discomfort in rats with hepatomegaly

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