Treatment of αVβ3 integrin abnormalities increases pregnancy success rates after failed IVF cycles

Farrell, Rhonda; Gray, Diana L.; Gindlesperger, V.; Arredondo, Francisco; Liu, J.; Mola, J. Ricardo Loret de

doi:10.1016/s0015-0282(03)01960-5

Cited by 5 publications

(2 citation statements)

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“…These results have been confirmed in a murine model [ 37 ]. Farrell et al demonstrated that an 8-week course of GnRHa and norethindrone acetate resulted in 9 ongoing IVF pregnancies in 11 patients with absent endometrial β 3 integrin expression [ 38 ]. We had previously demonstrated a 48.6% prevalence of aberrant expression in a group of consecutive high risk IVF patients with endometriosis and/or prior failed embryo transfer despite good embryo quality [ 39 ].…”

Section: Impact Of Medical Therapy For Endometriosis On Ivf Outcommentioning

confidence: 99%

Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies

Surrey

2015

BioMed Research International

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The assisted reproductive technologies, particularly in vitro fertilization (IVF), represent the most efficient and successful means of overcoming infertility associated with endometriosis. Although older studies suggest that IVF outcomes are compromised in endometriosis patients, more contemporary reports show no differences compared to controls. The exception may be evidence of poorer outcomes and diminished ovarian response in women with advanced disease, particularly those with significant ovarian involvement or prior ovarian surgery. Prolonged pre-IVF cycle suppressive medical therapy, particularly gonadotropin releasing hormone agonists, appears to improve success rates in a subset of endometriosis patients. However, as of yet, there is no diagnostic marker to specifically identify those who would most benefit from this approach. Pre-IVF cycle surgical resection of nonovarian disease has not been consistently shown to improve outcomes with the possible exception of resection of deeply invasive disease, although the data is limited. Precycle resection of ovarian endometriomas does not have benefit and should only be performed for gynecologic indications. Indeed, there is a large body of evidence to suggest that this procedure may have a deleterious impact on ovarian reserve and response. A dearth of appropriately designed trials makes development of definitive treatment paradigms challenging.

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Section: Impact Of Medical Therapy For Endometriosis On Ivf Outcommentioning

confidence: 99%

Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies

Surrey

2015

BioMed Research International

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“…Nine experienced ongoing pregnancies. 61 In an effort to resolve this issue, Surrey and colleagues recently reported the results of a prospective randomized pilot trial of 36 endometriosis patients undergoing IVF. 62 The patients were randomized after assessing β3 integrin expression to receive either 3 months of GnRHa prior to initiating ovarian stimulation or to proceed directly to ovarian stimulation.…”

Section: Does Pre-ivf Cycle Medical Suppression Improve Outcomes?mentioning

confidence: 99%

Endometriosis and Assisted Reproductive Technologies: Maximizing Outcomes

Surrey

2013

Semin Reprod Med

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In vitro fertilization (IVF) represents the most efficient means of overcoming endometriosis-related infertility. Compromised pelvic anatomy and a hostile peritoneal environment are bypassed. Despite the results of early trials, more contemporary outcomes data would suggest that when controlled for age, IVF cycle outcome is not compromised by the presence of endometriosis. One exception to this concept is the finding that patients with ovarian endometriomas demonstrate poorer response to gonadotropin therapy, although it is not clear that this affects the likelihood of implantation. Surgical ablation of superficial endometriosis has no clear impact on IVF pregnancy rates, although a small number of recent trials suggest that pre-cycle resection of deeply infiltrative disease may be beneficial. With the exception of traditional gynecologic indications, there is no evidence to suggest that resection of ovarian endometriomas has any positive impact on cycle outcome. There are, in fact, data demonstrating that resection may exert a deleterious effect on ovarian reserve. A subset of patients will benefit from administration of a prolonged course of a gonadotropin-releasing hormone agonist prior to an IVF cycle. However, the characteristics of that subset have not been identified. It would be logical to consider this approach in women with more advanced disease, severe symptoms, and a history of implantation failure. Data on the impact of other pre-cycle medical interventions such as aromatase inhibitors, danazol, or oral contraceptives are more limited. There is also no evidence to suggest that the ovarian stimulation associated with IVF induces progression of endometriosis.

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Human implantation: the last barrier in assisted reproduction technologies?

Edwards¹

2006

Reproductive BioMedicine Online

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Implantation processes are highly complex involving the actions of numerous hormones, immunoglobulins, cytokines and other factors in the endometrium. They are also essential matters for the success of assisted reproduction. The nature of early embryonic development is of equal significance. It involves ovarian follicle growth, ovulation, fertilization and preimplantation growth. These processes are affected by imbalanced chromosomal constitutions or slow developmental periods. Post-implantation death is also a significant factor in cases of placental insufficiency or recurrent abortion. Clearly, many of these matters can significantly affect birth rates. This review is concerned primarily with the oocyte, the early embryo and its chromosomal anomalies, and the nature of factors involved in implantation. These are clearly among the most important features in determining successful embryonic and fetal growth. Successive sections cover the endocrine stimulation of follicle growth in mice and humans, growth of human embryos in vitro, their apposition and attachment to the uterus, factors involved in embryo attachment to uterine epithelium and later stages of implantation, and understanding the gene control of polarities and other aspects of preimplantation embryo differentiation. New aspects of knowledge include the use of human oocyte maturation in vitro as an approach to simpler forms of IVF, and new concepts in developmental genetics.

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Treatment of αVβ3 integrin abnormalities increases pregnancy success rates after failed IVF cycles

Cited by 5 publications

References 0 publications

Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies

Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies

Endometriosis and Assisted Reproductive Technologies: Maximizing Outcomes

Human implantation: the last barrier in assisted reproduction technologies?

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