Treatment Optimization of Non-Alcoholic Steatohepatitis in Obesity Patients With Comorbidity With Chronic Obstructive Pulmonary Disease: Correction of Dyslipidemia and Insulin Resistance

Хухліна, О. С.; Hryniuk, O. Ye.; Antoniv, A. A.; Kanovska, L. V.; Mandryk, O. Ye.

doi:10.24061/1727-4338.xix.1.71.2020.16

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The incidence of non-alcoholic fatty liver disease and its more severe form, NASH, is rising [13,14]. Patients with advanced fibrosis or cirrhosis from NASH are at increased risk of complications, including the development of hepatocellular carcinoma [15].…”

Section: Discussionmentioning

confidence: 99%

Influence of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease

Kotsiubiichuk

Хухліна

Antoniv

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

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Background. Hepatic steatosis and nonalcoholic steatohepatitis (NASH) are considered the most common liver pathologies, which in developed countries is observed in 20–30 % of the adult population. Patients with diabetes mellitus (DM) often develop non-specific kidney lesions such as asymptomatic bacteriuria, pyelonephritis, kidney carbuncle, kidney abscess, kidney tuberculosis, necrotizing papillitis, or papillary necrosis, which significantly complicate the course of diabetic nephropathy (DN). DN accounts for 40 % of complications in type 1 DM and 5–15 % among patients with type 2 DM. The purpose of the study is to clarify the impact of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease (DКD). Materials and methods. One hundred and sixty patients with NASH with comorbid type 2 DM of moderate severity and DКD stages I–IV were examined. A prospective study was conducted, which involved 160 patients and 30 practically healthy individuals. In particular, 25 patients with NASH and type 2 diabetes (group 1), 20 people with NASH and class I obesity (group 2), 70 patients with NASH stage I–IV (group 3), of whom 31 patients (44.3 %) had DКD stage I–II (group 3a), 20 (28.6 %) stage III (group 3b), 19 (27.1 %) had DKD stage IV (group 3c). Results. In patients with NASH, type 2 DM, and DKD stage I–IV, hypoalbuminemia was found to be probably higher compared to that of patients with type 2 DM, DКD stage I–IV and without NASH that indicates the influence of NASH on the level of albuminemia; higher blood level of creatinine and urea; lower glomerular filtration rate, which confirms the negative effect of NASH on the course of type 2 DM with DКD. In the presence of NASH, patients with DКD had a higher level of albuminuria, urinary creatinine, albumin-creatinine ratio than if it’s absent. Conclusions. Indicators of the renal functional state in patients with NASH and type 2 DM varied depending on the presence of DКD and its stage. As the stage of DКD increased, the content of albumin in the blood decreased, the levels of creatinine and urea increased. The result of the detected changes was an increase in glomerular filtration rate, which indicates the phenomenon of hyperfiltration, which is specific for the initial stages of DКD.

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Section: Discussionmentioning

confidence: 99%

Influence of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease

Kotsiubiichuk

Хухліна

Antoniv

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

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“…Актуальність проблеми. Істотне зростання захворюваності на жирову хворобу печінки (ЖХП) алкогольного та неалкогольного генезу в останні 10 років в Україні та світі зумовлює значну зацікавленість наукової спільноти даною проблемою [7,8,9,10]. Частою коморбідною патологією на тлі ЖХП алкогольної природи є анемія, яка істотно обтяжує перебіг ЖХП.…”

Section: Bukovinian Medicalunclassified

Histopathological features of liver tissue in non-alcoholic and alcoholic steatohepatitis depending on the presence of concomitant anemia

Antofiichuk¹,

Давыденко²,

Хухліна³

et al. 2021

Buk. Med. Herald

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The aim: to study some histopathological changes in the liver affected by steatohepatitis of various etiologies with the presence of anemia. Material and methods. Liver biopsies were analyzed in 30 patients with non-alcoholic steatohepatitis (NASH) and 20 patients with alcoholic steatohepatitis (ASH). The morphological examination of the liver was carried out according to the standard methods. The histopathological features of the liver were established on the basis of hematoxylin and eosin staining method, with confirmation, if necessary, by the histochemical methods - staining for fat (method with Sudan-III) and collagen fibers (method with chromotropic-water blue by NZ Slinchenko). Microspectrophotometric studies were performed using a cytological analyzer with software "VideoTest - Size 5.0" (2000). Results. A number of parameters revealed the statistical differences in the average trends with the use of the nonparametric Mann-Whitney method (p<0.05). The highest rate of hepatocyte necrosis was observed in the patients with ASH with anemia, in particular, more than a third of hepatocytes in these patients had signs of colic necrosis, which was more pronounced in ASH than in NASH. NASH with anemia was accompanied by more pronounced necrosis of hepatocytes than NASH without anemia. In ASH without anemia, the percentage of affected hepatocytes was on average approximately the same as in NASH without anemia. Fatty dystrophy of hepatocytes was observed in all the patients with NASH and ASH, but the severity of the general pathological process was not the same. Conclusions. Due to the comorbidity of fatty liver disease with anemia in both NASH and ASH, a much higher percentage of hepatocytes affected by reversible swelling are formed, which coincides with the tendency for hepatocyte oncosis. Anemia affects the nature of connective tissue growth in NASH and ASH (in ASH, the specific volume of connective tissue was higher than in NASH). At the same time, the intensity of regenerative processes in the liver (ductal reactions of the liver) is most pronounced in patients with anemia, and most - in ASH.

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Pathogenetic Substantiation of Application of Antral in Patients With Comorbidal Course of Non-Alcoholic Steathepatitis, Obesity and Chronic Obstructive Pulmonary Disease – Influence on Connective Tissue Components and Blood Content of Hydrogen Sulfide

Хухліна¹,

Hryniuk²,

Roshchuk³

et al. 2021

VPBM

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Treatment Optimization of Non-Alcoholic Steatohepatitis in Obesity Patients With Comorbidity With Chronic Obstructive Pulmonary Disease: Correction of Dyslipidemia and Insulin Resistance

Cited by 4 publications

References 7 publications

Influence of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease

Influence of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease

Histopathological features of liver tissue in non-alcoholic and alcoholic steatohepatitis depending on the presence of concomitant anemia

Pathogenetic Substantiation of Application of Antral in Patients With Comorbidal Course of Non-Alcoholic Steathepatitis, Obesity and Chronic Obstructive Pulmonary Disease – Influence on Connective Tissue Components and Blood Content of Hydrogen Sulfide

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