Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review

Issa, Allaudin; Sebro, Kirby; Kwok, Abigail; Janisch, Florian; Grossmann, Nico C.; Lee, Esther; Lucky, Marc; Oliveira, Pedro; Lau, Maurice; Parnham, Arie; Sangar, Vijay; Fankhauser, Christian Daniel

doi:10.1016/j.euf.2021.04.026

Cited by 18 publications

(8 citation statements)

References 23 publications

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“…The mean age of patients with PeIN is 64 years 1 . PeIN can be divided in to differentiated and non‐differentiated, with the undifferentiated subtype usually related to human papilloma virus (HPV) infection 1,2 . Approximately 80% of PeIN have HPV DNA and the predominant oncogenic HPV type is HPV‐16 3 .…”

Section: Introductionmentioning

confidence: 99%

“…The use of imiquimod has previously been described for the treatment of PeIN with a complete success rate of 63% and no response of 29% 6 . Furthermore, a systemic review of the use of imiquimod reported a 100%–40% response rate and 20% recurrence rate 2 . Other modalities to treat this disorder include cryotherapy, curettage and diathermy, carbon dioxide or Nd: Yag laser, photodynamic therapy, topical 5‐fluorouracil, surgical excision, circumcision and Mohs surgery 5–7 .…”

Section: Introductionmentioning

confidence: 99%

“…Treatments may vary depending on the site of the PeIN. However, tissue‐sparing methods should be considered first line for PeIN of the glans 2 …”

Section: Introductionmentioning

confidence: 99%

“…1 PeIN can be divided in to differentiated and non-differentiated, with the undifferentiated subtype usually related to human papilloma virus (HPV) infection. 1,2 Approximately 80% of PeIN have HPV DNA and the predominant oncogenic HPV type is HPV-16. 3 Non-HPV-related risk factors include lichen sclerosus, poor penile hygiene, the absence of circumcision and smoking, but the presence of chronic inflammation from any source may be important.…”

Section: Introductionmentioning

confidence: 99%

“…6 Furthermore, a systemic review of the use of imiquimod reported a 100%-40% response rate and 20% recurrence rate. 2 Other modalities to treat this disorder include cryotherapy, curettage and diathermy, carbon dioxide or Nd: Yag laser, photodynamic therapy, topical 5fluorouracil, surgical excision, circumcision and Mohs surgery. [5][6][7] All show variable success with limited data due to the low incidence, and no treatment has been shown to be superior to others.…”

Section: Introductionmentioning

confidence: 99%

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Immunotherapy for the treatment of penile intraepithelial neoplasia associated with human papilloma virus type 16 using topical imiquimod and human papilloma virus vaccination

et al. 2021

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Penile intraepithelial neoplasia (PeIN) is frequently associated with human papilloma virus (HPV). Three cases of PeIN associated with HPV-type 16 were successfully treated with topical imiquimod and concurrent HPV vaccination. Human papilloma vaccine protects against oncogenic human papilloma viruses. In New Zealand, a decline in incidence of PeIN is anticipated with the recent funding of human papilloma vaccine for boys and young men aged 9-26 years. Therefore, HPV vaccination may have a role for treatment of PeIN and prophylaxis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Treatments may vary depending on the site of the PeIN. However, tissue‐sparing methods should be considered first line for PeIN of the glans 2 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Immunotherapy for the treatment of penile intraepithelial neoplasia associated with human papilloma virus type 16 using topical imiquimod and human papilloma virus vaccination

et al. 2021

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Dermatoses of the Male Genitalia

Bunker,

Watchorn

2024

Rook's Textbook of Dermatology

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Male genital dermatoses present a diverse array of symptoms including itch, pain, cracking, blistering, bruising, dysuria and dyspareunia, and can affect quality of life in terms of sexual, dermatological, psychological and urological morbidity. Dermatoses such as psoriasis, lichen planus and atopic eczema may manifest in specific morphology in the genital region, while other dermatoses such as lichen sclerosus, have a genital predilection, and subtle clinical signs that require assiduous assessment and a trained eye to detect. Treatment may present similar challenges due to the essential functions and associated stressors in the region. Precancerous pathologies also present challenges in terms of clinical recognition, and treatment, with diverse morphologies and region‐specific predisposing factors, and surgical challenges in terms of preserving sexual and urinary function.

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