Treatment options for dysfunctional uterine bleeding: evaluation of clinical results

Pados, George; Athanatos, Dimitrios; Tsolakidis, Dimitrios; Stamatopoulos, P; Tarlatzis, Basil C.

doi:10.1007/s10397-011-0674-8

Cited by 5 publications

(4 citation statements)

References 85 publications

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“…According to the study, uterine hemorrhage decreased by 72% in comparison to 38% in the placebo group 8 h after intravenous premarin was administered. 8 According to a theory, the endometrium heals itself as a result of the induced growth caused by growing oestradiol levels during the primary follicular phase of a typical menstrual cycles. Estrogen also has an impact on the endometrium by reducing capillary permeability, increasing fibrinogen levels, clotting factors, and platelet aggregation, which in turn encourages coagulation and decreases capillary permeability.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Uterine artery embolization after dysfunctional uterine bleeding due to incomplete abortion in female

Jha,

Inamdar,

Dhobale

2024

F1000Res

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Dysfunctional uterine bleeding (DUB), a serious clinical challenge caused by incomplete abortion in female, calls for efficient and minimally invasive therapies to treat symptoms and protect reproductive health. Uterine artery embolization (UAE) has been discovered as a viable therapeutic strategy to treat DUB following an incomplete abortion. The existing information and clinical experience of UAE for this particular indication were thoroughly reviewed. A female’s quality of life may be negatively affected by incomplete abortion, which is defined as residual fetal tissue inside the uterine cavity. This frequently results in heavy and continuous uterine bleeding. Medical procedures and traditional management techniques such as dilatation and curettage (D&C) do not always produce the desired effects or might have inherent dangers. UAE, a less invasive technique first developed for treating uterine fibroids, has shown promise as a substitute solution for DUB caused by an incomplete abortion.

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Section: Discussionmentioning

confidence: 99%

Case Report: Uterine artery embolization after dysfunctional uterine bleeding due to incomplete abortion in female

Jha,

Inamdar,

Dhobale

2024

F1000Res

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“…Medical treatment is considered as a first-line treatment and includes tranexamic acid, non-steroidal anti-inflammatory drugs, combined oral contraception pill, progestogen, danazol, gonadotropin releasing hormone analogues (GnRH-a), and levonorgestrel releasing intra-uterine system. In cases of AUB resistant to medical treatment, physicians should offer women an alternative surgical treatment, choosing between hysteroscopic and non-hysteroscopic endometrial ablation techniques and hysterectomy [6].…”

Section: Introductionmentioning

confidence: 99%

Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial

Athanatos¹,

Pados²,

Venetis³

et al. 2015

Clin. Exp. Obstet. Gynecol.

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To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB). Materials and Methods: This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment. Results: The rate of amenorrhea at 12months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7). Conclusion: In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.

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“…While hysterectomy still remains the definitive surgical treatment for HMB, endometrial ablation in contrast is less invasive and associated with shorter hospital stay and recovery, significant less pain, and fewer complications [4][5][6][7]. Currently, there is a variety of endometrial ablation techniques used worldwide, which are well-established alternatives to hysterectomy for the management of women with HMB [5,8].…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of outpatient Thermachoice endometrial balloon ablation: a long-term 11-year outcome study

Kumar

Gupta

2013

Gynecol Surg

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The aim of this study was to evaluate the long-term treatment outcomes of outpatient Thermachoice balloon endometrial ablation under a direct local anaesthetic cervical block (LA-Thermachoice). This paper is a prospective cohort study and a postal questionnaire survey in a UK teaching hospital with the participation of 253 women with heavy menstrual bleeding (HMB) undergoing LA-Thermachoice over an 11-year period between 2001 and 2011. Treatment success was measured by postoperative bleeding patterns, improvement in dysmenorrhoea, patient satisfaction and post-procedure hysterectomy rates. LA-Thermachoice was completed in 98 % of women. The survey response rate was 78 %. The median follow-up interval was 71 months (SD 42). Seventy-nine percent of the responders reported significant improvement in HMB with 40 % amenorrhoea rate and 86 % improvement in dysmenorrhoea. Eighty-one percent felt that the benefit of procedure was maintained over a long period of time. Eighty-six percent of women were satisfied with the outcome of their procedure. The case notes of nonresponders were examined to check if any had undergone hysterectomy since the LA-Thermachoice procedure. In total, only 16 % of women had a hysterectomy. This study represents the largest published series of local anaesthetic thermal endometrial ablation, reporting clinical outcomes with 11 years (median 71 months) of post-treatment follow-up. It demonstrates that the patient satisfaction with LA-Thermachoice is high, and is maintained over a long period of time after the procedure.

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Treatment options for dysfunctional uterine bleeding: evaluation of clinical results

Cited by 5 publications

References 85 publications

Case Report: Uterine artery embolization after dysfunctional uterine bleeding due to incomplete abortion in female

Case Report: Uterine artery embolization after dysfunctional uterine bleeding due to incomplete abortion in female

Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial

The effectiveness of outpatient Thermachoice endometrial balloon ablation: a long-term 11-year outcome study

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