Treatment options to prevent diabetes in subjects with prediabetes: Efficacy, cost effectiveness and future outlook

Farr, Olivia M.; Mantzoros, Christos S.

doi:10.1016/j.metabol.2016.12.017

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…Chronic hyperglycemia is common to both type 1 and 2 DM, while insulin resistance is responsible of many neuropathies in type 2 DM [54,55]. Intriguingly, we showed that hyperglycemia impaired the corneal epithelial NAD + and NAMPT expression both in type 1 DM mice and type 2 DM patients, while NAD + could promote the proliferation and migration of high glucose-treated corneal epithelial cells in vitro.…”

Section: Discussionmentioning

confidence: 60%

Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice

Zhao

et al. 2021

Metabolism

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Section: Discussionmentioning

confidence: 60%

Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice

Zhao

et al. 2021

Metabolism

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“…Almost everyone who develops T2DM usually has prediabetes first, but not all patients with prediabetes end up with diabetes. Changes in lifestyle or the introduction of pharmacological intervention programs can significantly delay or even prevent T2DM development [ 45 , 46 ]. However, it has recently been shown that some patients may be at higher risk of T2DM onset that cannot be explained by lifestyle and metabolic factors [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study

Sidorkiewicz

Niemira

Maliszewska

et al. 2020

JCM

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Due to a global increase in the prevalence of type 2 diabetes mellitus (T2DM), there is an urgent need for early identification of prediabetes, as these people have the highest risk of developing diabetes. Circulating miRNAs have shown potential as progression biomarkers in other diseases. This study aimed to conduct a baseline comparison of serum-circulating miRNAs in prediabetic individuals, with the distinction between those who later progressed to T2DM and those who did not. The expression levels of 798 miRNAs using NanoString technology were examined. Spearman correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression modeling were performed. Gene ontology (GO) and canonical pathway analysis were used to explore the biological functions of the miRNA target genes. The study revealed that three miRNAs were upregulated in the serum samples of patients who later progressed to T2DM. Pathway analysis showed that the miRNA target genes were mainly significantly enriched in neuronal NO synthase (nNOS) signaling in neurons, amyloid processing, and hepatic cholestasis. ROC analysis demonstrated that miR-491-5p, miR-1307-3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). Validation by real-time quantitative polymerase chain reaction (qRT-PCR) confirmed our findings. The results suggest that circulating miRNAs can potentially be used as predictive biomarkers of T2DM in prediabetic patients.

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“…63 With most T2DM patients being overweight or obese it is important to achieve weight loss for prevention of T2DM along with managing the disease once it occurs. As reviewed by farr OM and Mantzoros, 64 the Finnish Diabetes Prevention Study showed that an intensive dietary and exercise programme reduced the overall risk of T2DM by 58%. 65 similarly in diabetes prevention program, moderate weight loss with Life Style interventions in an obese population with impaired glucose tolerance test (GTT) could decrease the incidence of T2DM by 58%, though metformin use only reduced it by 31%.…”

Section: Use Of Weight Loss In Prevention Of T2dm and Therapymentioning

confidence: 96%

Importance of Simultaneous Treatment of Obesity and Diabetes Mellitus: A Sequelae to the Understanding of Diabesity-A Review

Kaur¹,

Allahbadia²,

Singh³

2019

Obes Res Open J

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With the growing epidemic of obesity in children, adolescents and adults globally, obesity has been found to be a risk factor for many non-communicable diseases like type 2 diabetes mellitus (T2DM), hypertension, dyslipidemias and many cancers. So much so that recently a term diabesity (Obesity and diabetes in the same patient, especially when the obesity had a causal influence on the diabetes) got introduced. The aim of this systematic review was to study how we can tackle together so that we can take care of the mortality caused by obesity and T2DM being responsible for more mortalities replacing malnutrition even in developing countries. Methods We carried out a PubMed search, along with Excerpta Medica dataBASE (EMBASE)/Cochrane library, web sciences for the Medical Subject Headings (MeSH) Terms "obesity'', "diabetes mellitus (DM)'', "lifestyle including exercise'', "diet therapy for management of diabesity'', pharmacotherapy including foods rich in antidiabetics like anthocyanins'', "polyphenols'', "walnuts'', "monoterpenes'' for same including "bariatric surgery (BS)''. Results We found a total of 86,283 articles pertaining to obesity and DM together of which we selected 92 articles for this review after getting articles after searching cross references. No meta-analysis was done. Conclusion Till date body mass index (BMI) is used to classify overweight and obesity. With decreased muscle mass being common in these obese patients it is important to measure the body composition. Further, one has to monitor body composition when getting the patient to lose weight. Importantly, the criterion used for labelling obesity also varies in different geographical areas in view of different phenotype of diabetes in South Asia. Weight loss can be achieved using lifestyle interventions like diet, exercise and importance of combining natural products from food in attaining weight loss along with controlling hyperglycemia utilizing pharmacotherapies obesity and T2DM, control. Bariatric Surgery (BS) remains the last resort for morbidly obese although it might have to be resorted in individuals where diabetes is resistant to medical treatment and be needed for those with BMI greater than 35 kg/m 2 or even less in case of resistant diabetics. Role of diets rich in walnuts, anthrocyanins, soyabean, chickpeas, curcumin, polyphenols and other vitamins and micronutrients including vitamin A, also needs to be considered while treating diabesity.

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Treatment options to prevent diabetes in subjects with prediabetes: Efficacy, cost effectiveness and future outlook

Cited by 5 publications

References 47 publications

Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice

Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice

Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study

Importance of Simultaneous Treatment of Obesity and Diabetes Mellitus: A Sequelae to the Understanding of Diabesity-A Review

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