Treatment outcome of tuberculosis patients under directly observed treatment short course and its determinants in Shangla, Khyber-Pakhtunkhwa, Pakistan: A retrospective study

Ahmad, Tauseef; Haroon, ​; Khan, Muhammad Mumtaz; Ejeta, Eyasu; Karami, Manoochehr; Ohia, Chinenyenwa

doi:10.4103/ijmy.ijmy_69_17

Cited by 19 publications

(23 citation statements)

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“…having an outcome of cured or treatment completed) at the end of the treatment was 86.2%, which is similar to other resource-constrained countries such as India (81-83%) [23][24][25], Ethiopia (85.6%) [26], Nigeria (83.1%) [27], Uzbekistan (83%) [28], Thailand (78.5-87.5%) [29], and higher than war affected countries such as Somalia (81.8%) [30], Iran (83.1%) [31] and Afghanistan (77.7%) [32]. However, the treatment success rate in our study was lower than the treatment success rate reported in the previous studies in Pakistan [13,33]. It is also lower than the global End TB Strategy targets.…”

Section: Discussioncontrasting

confidence: 71%

“…Monitoring treatment outcomes among war affected countries such as Pakistan provides evidence to assess the effectiveness of TB control programs. There are few epidemiological studies conducted in Pakistan on TB treatment outcomes [13][14][15][16][17]. However, data are limited between 2011 and 2014 in Khyber Pakhtunkhwa for the analysis of trends.…”

Section: Introductionmentioning

confidence: 99%

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Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

et al. 2020

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“…Patients who were more than 14 years of age were about 12 times more likely to have successful treatment outcomes. While, this finding is collaborated by a hospital-based study carried out in Egypt and Pakistan whereby patients older than fifteen years of age had the favorable treatment outcome (p value <0.05), it is dissimilar to findings from other studies where the pediatric age category had better outcomes than the older population [28,29,17]. The poor treatment outcome observed in this study could be as a result of the developing immunity or nourishment status of this population.…”

Section: Discussioncontrasting

confidence: 86%

Determinants of Successful Tuberculosis Treatment Outcome in a State University Teaching Hospital in South East, Nigeria: A 5 Year Retrospective Study

Orji¹,

Chime²,

Ossai

2019

IJTDH

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Aim: The 2018 World Health Organization Global Tuberculosis Report enlisted Nigeria as one of the seven countries worldwide that accounted for 64% of all new cases of tuberculosis. The aim of this study was to assess the magnitude and determinants of tuberculosis treatment outcomes at a Tertiary Hospital in South East, Nigeria. Study Design: Retrospective cohort. Place and Duration: The Enugu State University Teaching Hospital Directly Observed Treatment Center, between April 2009 and March 2013. Methods: Completely filled data were extracted from tuberculosis treatment cards and registers of 445 clients (255 males, 190 females; age range 0-90 years) who assessed care at the DOTS clinic. Tuberculosis treatment success outcome is defined as cured or completed TB treatment. Results: Of 445 registered patients, majority was males (57.3%), lived in urban areas (68.1%), and were newly diagnosed (97.8%). Of the 93.7% with pulmonary tuberculosis, 62% were smear negatives cases (62%). While the male to female ratio of the clients was 1.3:1, their mean age was 42 ± 16.7 years. About half (50.6%) had chest x-ray findings that were not diagnostic of Tuberculosis. While TB/HIV co-infection rate was 32.8%; 16% and 19.3% had commenced anti -retroviral and co-trimoxazole preventive treatment respectively. Treatment success was reported in 67.9% of all clients and was associated with being older than 14 year (AOR=12.0, 95% CI: 2.5 – 58.0) and having positive chest findings (AOR = 2.6, 95% CI: 0.3-0.6). Conclusions: The TB success rate in was 67.9% Being older than 14 years, having PTB and positive chest x ray findings were the predictors of good treatment outcome in this study. There is an urgent need to track and report the treatment outcome of patients who are lost to follow up since they constitute 20% of missed cases in this center.

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“…Afghanistan the treatment success rates were (77.5%) in male and (84.4%) in female patients [35], and (77.7%) [36]. However, the treatment success rate was lower than that reported in the previous studies in Pakistan [13,37]. Type of TB, age, and year of treatment commencement were significantly associated with successful treatment outcomes.…”

Section: Discussionmentioning

confidence: 78%

“…There are few epidemiological studies conducted in Pakistan on TB treatment outcomes [13][14][15][16][17].…”

mentioning

confidence: 99%

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

Ahmad

Jadoon²,

Khan

et al. 2020

Preprint

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Abstract Background: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. Methods: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. Results: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0-20 years (adjusted odds ratio, AOR= 3.47; 95% confidence interval, CI)= 1.54-7.81; P= 0.003), smear-positive pulmonary TB (AOR)= 3.58; 95% CI= 1.89-6.78; P= <0.001), treatment category (AOR= 4.71; 95% CI= 1.17-18.97; P= 0.029), and year of enrollment 2012 (AOR= 6.26; 95% CI= 2.52-15.59; P= <0.001) were significantly associated with successful treatment outcome. Conclusions: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes.

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Treatment outcome of tuberculosis patients under directly observed treatment short course and its determinants in Shangla, Khyber-Pakhtunkhwa, Pakistan: A retrospective study

Cited by 19 publications

References 1 publication

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

Determinants of Successful Tuberculosis Treatment Outcome in a State University Teaching Hospital in South East, Nigeria: A 5 Year Retrospective Study

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

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