Treatment outcomes after highly active antiretroviral therapy: a meta-analysis of randomised controlled trials

Enanoria, Wayne; Ng, Cherie; Saha, Sona; Colford, John M.

doi:10.1016/s1473-3099(04)01057-6

Cited by 24 publications

(13 citation statements)

References 68 publications

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“…Without restricting the search to papers specific to immigrants, we identified 13 systematic reviews and guideline articles providing evidence on screening for HIV. 247−259 We identified and appraised longitudinal studies of antiretroviral treatment, 260,261 a meta-analysis on behaviour change related to HIV screening tests, 249 a meta-analysis on antiretroviral therapy 256 and a Cochrane systematic review on antiretroviral treatment. 247 One hundred and four titles addressed the burden of HIV and barriers to care for immigrant populations.…”

Section: Resultsmentioning

confidence: 99%

Evidence-based clinical guidelines for immigrants and refugees

Pottie¹,

Greenaway²,

Feightner³

et al. 2010

Canadian Medical Association Journal

397

333

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Section: Resultsmentioning

confidence: 99%

Evidence-based clinical guidelines for immigrants and refugees

Pottie¹,

Greenaway²,

Feightner³

et al. 2010

Canadian Medical Association Journal

397

333

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“…Studies performing multiple comparisons on the same treatment group or not specifying whether there was patient overlap between such repeated comparisons could result in a potential loss of independence. In such cases, adjustments were made to the weighting of studies using a previously described method for conservatively inflating variance estimates (Jordan et al 2002, Enanoria et al 2004.…”

Section: Statisticsmentioning

confidence: 99%

Comparison of cemented and uncemented fixation in total hip replacement

et al. 2007

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Background The choice of optimal implant fixation in total hip replacement (THR)-fixation with or without cement-has been the subject of much debate.Methods We performed a systematic review and meta-analysis of the published literature comparing cemented and uncemented fixation in THR.Results No advantage was found for either procedure when failure was defined as either: (A) revision of either or both components, or (B) revision of a specific component. No difference was seen between estimates from registry and single-center studies, or between randomized and non-randomized studies. Subgroup analysis of type A studies showed superior survival with cemented fixation in studies including patients of all ages as compared to those that only studied patients 55 years of age or younger. Among type B studies, cemented titanium stems and threaded cups were associated with poor survival. An association was found between difference in survival and year of publication, with uncemented fixation showing relative superiority over time.Interpretation While the recent literature suggests that the performance of uncemented implants is improving, cemented fixation continues to outperform uncemented fixation in large subsets of study populations. Our findings summarize the best available evidence qualitatively and quantitatively and provide important information for future research.

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“…Different highly active antiretroviral therapy (HAART) regimens currently being in use and in development have been found in different countries for increasing life expectancy and immune status of HIV positive persons [2]. These HAART regimens typically include a combination of at least three drugs, such as different association of protease inhibitors (PI), non-nucleoside reverse transcriptase inhibitors (NNRTI) and nucleoside reverse transcriptase inhibitors (NRTI) [3].The introduction of these HAART has led to a marked reduction in AIDS-related morbidity and mortality [4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Predictors of Dyslipidemia on HAART and HAART Naive HIV Positive Persons in Defense Hospital, Addis Ababa, Ethiopia

Bayenes¹,

Ahmed²,

Shenkute³

et al. 2014

AJHR

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Abstract:Background: The introduction of highly active antiretroviral therapy (HAART) has led to a marked reduction in Acquired Immune Deficiency Syndrome (AIDS) related morbidity and mortality. However, HAART has been reported to be associated with a number of side effects in human immunodeficiency virus (HIV) positive persons among which dyslipidemia and lipodystrophy are common metabolic disorders. Objective: To assess the prevalence and predictors of dyslipidemia among HAART and HAART naive HIV positive persons in Defense Hospital, Addis Ababa-Ethiopia. Methods: A facility based comparative cross-sectional study among 228 HIV positive persons was conducted from September to October 2013. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was drawn for laboratory analysis. Lipid profiles were measured using clinical chemistry analyzer (HumStar80, USA). CD4 cell counting was done using BD FACS Count™ (BD, USA). Anthropometric measurement was done. Data was analyzed using SPSS version 20 for windows. Result: A total of 228, 114 on HAART and 114 HAART naïve HIV positive persons, were enrolled in the study. The overall prevalence of dyslipidemia was 63.6%. Prevalence of dyslipidemia in HAART naive and on HAART HIV positive persons was 61(53.5%) and 84(73.7%), respectively. The prevalence of TC≥200 mg/dl was 50% and 30%; HLD-c<40 mg/dl was 43.8% and 36%; LDL-c≥130mg/dl was 48.3% and 28.1%; and TG≥150 mg/dl 59.6% and 39% among on HAART and HAART naïve, respectively. Age greater than 40 years old (AOR = 3.27, 95% C.I: 1.47 -7.25), blood pressure ≥ 140/90 (AOR = 16.13, 95% C.I: 5.81 -44.75), being on HAART (AOR = 2.73, 95 % C.I: 1.35 -5.53), and body mass index > 25kg/m 2 (AOR = 1.92, 95 % C.I: 1.20 -4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher on HAART as compared to HAART naïve HIV positive persons. It is important to have well controlled cohort studies for the evaluation of long-term effects of HAART on lipid profiles.

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Treatment outcomes after highly active antiretroviral therapy: a meta-analysis of randomised controlled trials

Cited by 24 publications

References 68 publications

Evidence-based clinical guidelines for immigrants and refugees

Evidence-based clinical guidelines for immigrants and refugees

Comparison of cemented and uncemented fixation in total hip replacement

Prevalence and Predictors of Dyslipidemia on HAART and HAART Naive HIV Positive Persons in Defense Hospital, Addis Ababa, Ethiopia

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