Treatment outcomes and its associated factors among breast cancer patients at Kitui Referral Hospital

Wambua, Mwendwa Dickson; Degu, Amsalu; Tegegne, Gobezie Temesgen

doi:10.1177/20503121211067857

Cited by 5 publications

(8 citation statements)

References 37 publications

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“…More than two-thirds of the studies were published after 2010. Thirty-one studies (63.3%) included only female participants, while the remaining studies included both female and male (30.6%) or only male (6.1%) participants . The proportion of female participants was higher in the studies that included both sexes.…”

Section: Resultsmentioning

confidence: 99%

“…Following a thorough full-text review, 69 studies were reviewed. Of these, 49 studies that met the eligibility criteria were included in the narrative synthesis, and 40 of them underwent meta-analysis for a more in-depth and comprehensive analysis (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Of 49 studies included in the systematic review, 13 were conducted in Nigeria; 4 each in Ethiopia and South Africa; 3 each in Sudan, Ghana, Uganda, and Burkina Faso; 2 each in Kenya, Malawi, Cameroon, Senegal, and multiple countries; and 1 each in Gambia, Zimbabwe, Tanzania, Mozambique, Congo, and Guinea . More than two-thirds of the studies were published after 2010.…”

Section: Resultsmentioning

confidence: 99%

“…Following a thorough full-text review, 69 studies were reviewed. Of these, 49 studies that met the eligibility criteria 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 were included in the narrative synthesis, and 40 of them 20 , 21 , 22 , 23 , 25 , 27 , 29 , 30 , 31 , 32 ,…”

Section: Resultsmentioning

confidence: 99%

“…Of 49 studies included in the systematic review, 13 were conducted in Nigeria 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ; 4 each in Ethiopia 33 , 34 , 35 , 36 and South Africa 37 , 38 , 39 , 40 ; 3 each in Sudan, 41 , 42 , 43 Ghana, 44 , 45 , 46 Uganda, 47 , 48 , 49 and Burkina Faso 50 , 51 , 52 ; 2 each in Kenya, 53 , 54 Malawi, 55 , 56 Cameroon, 57 , 58 Senegal, 59 , 60 and multiple countries 61 , 62 ; and 1 each in Gambia, 63 Zimbabwe, 64 Tanzania, 65 Mozambique, 66 Congo, 67 and Guinea. 68 More than two-thirds of the studies were published after 2010.…”

Section: Resultsmentioning

confidence: 99%

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Survival Patterns Among Patients With Breast Cancer in Sub-Saharan Africa

Limenih,

Mekonnen,

Birhanu

et al. 2024

JAMA Netw Open

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ImportanceBreast cancer is the most prevalent cancer globally with tremendous disparities both within specific regions and across different contexts. The survival pattern of patients with breast cancer remains poorly understood in sub-Saharan African (SSA) countries.ObjectiveTo investigate the survival patterns of patients with breast cancer in SSA countries and compare the variation across countries and over time.Data SourcesEmbase, PubMed, Web of Science, Scopus, and ProQuest were searched from inception to December 31, 2022, with a manual search of the references.Study SelectionCohort studies of human participants that reported 1-, 2-, 3-, 4-, 5-, and 10-year survival from diagnosis among men, women, or both with breast cancer in SSA were included.Data Extraction and SynthesisIndependent extraction of study characteristics by multiple observers was performed using open-source software, then exported to a standard spreadsheet. A random-effects model using the generalized linear mixed-effects model was used to pool data. The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guideline for reporting was followed.Main Outcome and MeasuresSurvival time from diagnosis.ResultsForty-nine studies were included in the review with a sample size ranging from 21 to 2311 (total, 14 459; 196 [1.35%] men, 13 556 [93.75%] women, and 707 [4.90%] unspecified; mean age range, 38 to 71 years), of which 40 were summarized using meta-analysis. The pooled 1-year survival rate of patients with breast cancer in SSA was 0.79 (95% CI, 0.67-0.88); 2-year survival rate, 0.70 (95% CI, 0.57-0.80); 3-year survival rate, 0.56 (95% CI, 0.45-0.67); 4-year survival rate, 0.54 (95% CI, 0.43-0.65); and 5-year survival rate, 0.40 (95% CI, 0.32-0.49). The subgroup analysis showed that the 5-year survival rate ranged from 0.26 (95% CI, 0.06-0.65) for studies conducted earlier than 2010 to 0.47 (95% CI, 0.32-0.64) for studies conducted later than 2020. Additionally, the 5-year survival rate was lower in countries with a low human development index (HDI) (0.36 [95% CI, 0.25-0.49) compared with a middle HDI (0.46 [95% CI, 0.33-0.60]) and a high HDI (0.54 [95% CI, 0.04-0.97]).Conclusions and RelevanceIn this systematic review and meta-analysis, the survival rates for patients with breast cancer in SSA were higher in countries with a high HDI compared with a low HDI. Enhancing patient survival necessitates a comprehensive approach that involves collaboration from all relevant stakeholders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Survival Patterns Among Patients With Breast Cancer in Sub-Saharan Africa

Limenih,

Mekonnen,

Birhanu

et al. 2024

JAMA Netw Open

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Five-year survival rate of cancer patients in Ethiopia – systematic review and meta-analysis, 2022

Gedfew,

Afenigus,

Akalu

et al. 2024

International Journal of Surgery Oncology

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Background: Cancer and other non-communicable diseases (NCDs) were once thought to be diseases of high-income countries. However, new studies suggest that they are now a major public health burden in low- and middle-income countries as well. The rate of survival after diagnosis significantly varied across types of cancer and the treatment options they received. Therefore, we conducted this study to determine the survival status of cancer patients in Ethiopia. Methods: PubMed, Web of Science, Google Scholar, and Scopus databases from inception to 10 April 2022 were searched to identify relevant studies. A funnel plot and Egger’s regression test were used to determine publication bias. The I 2 statistic was used to check heterogeneity between the studies. DerSimonian and Laird random effects model was applied to estimate pooled effect size and 95% confidence interval across studies. Sensitivity analysis was deployed to determine the effect of a single study on the overall estimation, and the analysis was done using STATA Version 14 software. Results: A total of 19 studies with 12 847 study participants were included to estimate the pooled survival rate of cancer patients. The estimated pooled survival rate of cancer patients in Ethiopia was 57.15 (95% CI: 56.34–57.97). Regarding the subgroup analysis, based on cancer type, the highest pooled survival rate was recorded among prostate cancer patients at 80.47 (95% CI: 73.60–87.34), followed by cervical cancer patients at 60.89 (95% CI: 37.78–84.00) while the smallest was among colorectal cancer patients at 40.04 (95% CI: 9.11–70.9) and based on study design the highest pooled survival rate was among prospective cohort study at 63.91 (95% CI: 30.86–96.96). Based on publication year, the highest pooled survival rate was recorded in 2020 with 69.61 (95% CI: 48.51–90.70), followed by in 2018 at 63.13 (95% CI: 50.01–76.25). Conclusion: The survival rate of cancer patients is low in Ethiopia. This demonstrates that the survival of cancer patients is a major problem in Ethiopia. Therefore, situation-based interventions and preventive strategies should be developed to enhance the survival rate of cancer patients.

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