Treatment Outcomes of Childhood TB in Lagos, Nigeria

Adejumo, Olusola Adedeji; Daniel, Olusoji; Adebayo, Bisola; Adejumo, Esther Ngozi; Jaiyesimi, Ebunoluwa Olasumbo; Akang, Gabriel; Awe, Ayodele

doi:10.1093/tropej/fmv089

Cited by 47 publications

(77 citation statements)

References 7 publications

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“…The result of this study was congruent with a study conducted in Nigeria [24,25]. In addition, it was in line with a study conducted from an international epidemiological database network with 80% of effective treatment outcomes among children taking anti-TB treatment [26].…”

Section: Discussionsupporting

confidence: 89%

Childhood tuberculosis treatment outcome and its association with HIV co-infection in Ethiopia: a systematic review and meta-analysis

Belay

Wubneh

2020

Trop Med Health

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Section: Discussionsupporting

confidence: 89%

Childhood tuberculosis treatment outcome and its association with HIV co-infection in Ethiopia: a systematic review and meta-analysis

Belay

Wubneh

2020

Trop Med Health

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“…4,5 Overall, the childhood treatment success rate was similar in Nouakchott and in the rest of Mauritania, but was lower than in adults (61% vs. 70%), and also lower than in other settings in Africa (72-85%). 12,[25][26][27] The LTFU rate of 13% was similar to that in other countries (e.g., 18% in Togo), and reflects the fragmentation of diagnosis and treatment in Mauritania.…”

Section: Discussionsupporting

confidence: 62%

Childhood tuberculosis in Mauritania, 2010–2015: diagnosis and outcomes in Nouakchott and the rest of the country

Adè

Hinderaker

et al. 2017

public health action

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The National Tuberculosis Programme, Mauritania. To compare the diagnosis and treatment outcomes of childhood tuberculosis (TB) cases (aged<15 years) registered between 2010 and 2015 inside and outside Nouakchott, the capital city. This was a retrospective comparative cohort study. A total of 948 children with TB were registered. The registration rate was 10 times higher in Nouakchott. The proportion of children among all TB cases was higher inside than outside Nouakchott (7.5% vs. 4.6%, < 0.01). Under-fives represented 225 (24%) of all childhood TB cases, of whom 204 (91%) were registered in Nouakchott. Extra-pulmonary TB was more common in Nouakchott, while smear-negative TB was less common. Treatment success was similar inside and outside Nouakchott (national rate 61%). The principal unsuccessful outcomes were loss to follow-up outside Nouakchott (21% vs. 11%, < 0.01) while transfers out were more common in the city (25% vs. 14%, = 0.01). Being aged<5 years (OR 1.2, 95%CI 1.1-1.5) was associated with an unsuccessful outcome. This study indicates problems in the diagnosis and treatment of childhood TB in Mauritania, especially outside the city of Nouakchott. We suggest strengthening clinical diagnosis and management, improving communications between TB treatment centres and health services and pressing the TB world to develop more accurate and easy-to-use diagnostic tools for children.

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“…The result of this systemic review and meta-analysis was congruent with two studies conducted in Nigeria which was 77.4% and 83% of successful treatment outcome of childhood TB (23,24). And it is also in line with a study conducted from international epidemiological data base network with 80% of effective treatment outcome among children taking anti TB treatment (25).…”

Section: Discussionsupporting

confidence: 85%

Childhood Tuberculosis Treatment Outcome and Its Association with HIV-Co infection in Ethiopia, A Systematic Review and Meta-analysis

Belay

Wubneh

2019

Preprint

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Introduction Globally around one million children are infected with Tuberculosis. Childhood Tuberculosis is underestimated due diagnosis challenge. HIV infection can affect the TB disease progression and treatment outcome.Objectives The aim of this systematic review and meta-analysis is to determine the pooled estimates of childhood tuberculosis treatment outcome and to analyze the impact of HIV-co infection.Methods We searched all available articles using PubMed, Google scholar and a web of science. Additionally, reference lists of included studies and Ethiopian institutional research repositories were used. Searching was limited to studies conducted in Ethiopia and published in English language. Cohort, cross-sectional and case-control studies were included. A weighted inverse variance random effects- model was used. The overall variations between studies were checked by heterogeneity test Higgins’s method (I 2 ). All included studies were assessed with the JBI quality appraisal criteria. Publication bias was checked with the funnel plot and Egger’s regression test.Result A total of 6 studies with 5,389 participants were included in this systematic review and meta-analysis. The overall pooled estimate of successful treatment outcome was found to be 79.54% (95% CI: 73.00, 86.07). Of which 72.44% were treatment completed. Moreover, this study revealed that the treatment failure, defaulter and death were 0.15%, 5.36%, and 3.54%, respectively. Poor treatment outcome was higher among children with HIV co infection with an odds ratio of 3.15 (95% CI: 1.67, 5.94) as compared to HIV negative children.Conclusion The rate of successful treatment outcome of childhood tuberculosis in Ethiopia found to be low compared to the threshold suggested by the world health organization. HIV co infection is significantly associated with poor treatment outcome. Therefore, special attention better to be given for children infected with HIV.

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Treatment Outcomes of Childhood TB in Lagos, Nigeria

Abstract: There is a need to intensify effort at improving notification and treatment outcomes in children.

Cited by 47 publications

References 7 publications

Childhood tuberculosis treatment outcome and its association with HIV co-infection in Ethiopia: a systematic review and meta-analysis

Childhood tuberculosis treatment outcome and its association with HIV co-infection in Ethiopia: a systematic review and meta-analysis

Childhood tuberculosis in Mauritania, 2010–2015: diagnosis and outcomes in Nouakchott and the rest of the country

Childhood Tuberculosis Treatment Outcome and Its Association with HIV-Co infection in Ethiopia, A Systematic Review and Meta-analysis

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