Background: at present, the problem of treating common forms of patients with colorectal cancer does not lose its relevance due to the increase in incidence. Systemic chemotherapy is the main treatment for patients with unresectable liver metastases. However, a big problem of modern oncology is the question of further treatment tactics for patients with chemoresistant metastases.
Aims: to improve the results of treatment of patients with chemoresistant liver metastases of colorectal cancer.
Method: acad. A.M. Granov and the Central Clinical Hospital "RZD-Medicine" treated 36 patients with unresectable liver metastases of colorectal cancer. For all patients, systemic chemotherapy was considered inappropriate due to the development of chemoresistance or a high degree of toxicity. Patients underwent regional chemotherapy - chemoinfusion of the hepatic artery and/or chemoembolization of the hepatic artery.
Results: Evaluation of the treatment performed was carried out using the RECIST 1.1 scale. After 6 months, one (2.8%) patient received a partial response, 29 (80.5%) patients were diagnosed with stabilization, and 6 (16.7%) had progression. In two (5.6%) cases, a lethal outcome was recorded against the background of systemic progression of oncological disease. One year later, stabilization of the tumor process was detected in 21 (58.3%) cases, progression was detected in 15 (41.7%) cases. One-year survival of patients was 83.3%, OS - 22 months.
Conclusion. The use of interventional radiology methods has shown its effectiveness in patients with unresectable chemoresistant liver metastases of colorectal cancer.