Treatment patterns of children with spine and spinal cord tumors: national outcomes and review of the literature

Shweikeh, Faris; Quinsey, Carolyn; Murayi, Roger; Randle, Ryan; Nuño, Miriam A; Krieger, Mark D.; Johnson, J. Patrick

doi:10.1007/s00381-017-3433-y

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…RT has an important role in the palliative treatment of pediatric spinal tumors 18 . A survey involving an international research consortium found that the most common indication for palliative radiation was pain management (43%), with the spine being the second most common targeted area (14%) 19 .…”

Section: Discussionmentioning

confidence: 99%

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

Cardarelli-Leite

Rassekh

D'Ortenzio

et al. 2021

Preprint

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Background: Primary and secondary malignant tumors of the spine are relatively uncommon in the pediatric population but are associated with high morbidity and significantly decreased quality of life due to pain. Local management of these tumors is often challenging due to the importance of maintaining vertebral mechanical integrity as well as the spinal growth potential. Typically, surgery and/or radiation therapy have been used in the primary management of these tumors. However, treatment options become more limited when there is relapse or refractory disease, with re-resection or additional radiotherapy often not being viable therapies. The purpose of this study was to assess the feasibility of percutaneous vertebroplasty as a palliative treatment for intractable pain secondary to malignant tumors affecting the spine. Procedure: A retrospective review of all cases of vertebroplasty performed at a single institution between 2003 and 2020. Results: A total of 11 vertebral levels were treated in 3 children with relapsed cancers (two with alveolar rhabdomyosarcoma, and one with Wilms tumor). All three had clinical benefit with sustained significant improvement in their pain. Conclusions: Vertebroplasty is a currently underutilized modality that might provide excellent pain palliation in cases of relapsed cancer in the spine. Future prospective studies of its use in pediatric oncology are needed.

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Section: Discussionmentioning

confidence: 99%

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

Cardarelli-Leite

Rassekh

D'Ortenzio

et al. 2021

Preprint

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“…Intraspinal space-occupying lesions are rare in pediatric patients and lack of uniform evidence-based management strategies [5,7]. In contrast to adult intraspinal space-occupying lesions, pediatric cases have their own characteristics in clinical manifestations, histopathology, and surgical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…The intraspinal occupying-lesions comprising tumoral and non-tumoral lesions are relatively rare in children [1][2][3][4], but can lead to serious neurological impairments if left untreated. The majority of the lesions are neoplastic lesions with the incidence less than 3 per 1000,000 persons per year, accounting for only 5% of pediatric central nervous system (CNS) tumors [5]. Notably, the most frequent pediatric intraspinal tumors are residual embryonic tissue tumors and neuroepithelial tumors.…”

Section: Introductionmentioning

confidence: 99%

Intraspinal Space-Occupying Lesions in Children: Clinical Features, Neuroimaging and Surgical Outcomes of 27 Cases

Chang

Jiang

Wang

et al. 2021

Preprint

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Background: Pediatric intraspinal space-occupying lesions are relatively uncommon. However, these lesions can result in neurological disabilities due to misdiagnosis and delayed treatment. The main goal of the present study is to evaluate the clinical and radiological features and treatment options of pediatric intraspinal space-occupying lesions in order to improve the clinical recognition and management. Methods: Clinical data of 27 children with intraspinal space-occupying lesions who underwent surgery treatment in a tertiary-care hospital between 2010 and 2018 were retrospectively reviewed and analyzed. Results: Of these 27 patients, 14 (51.85%) were girls and 13 (48.15%) were boys. The most common age group affected was 10~14 years (62.96%, 9 girls and 8 boys in this age group). The mean age was 10.11 years old. Pain and weakness were the most common clinical symptoms. Preoperative magnetic resonance imaging (MRI) identified intramedullary (10 cases, 37.04%), intradural extramedullary (10 cases, 37.04%) and extradural (7 cases, 25.92%) lesions, respectively. The majority of the lesions were intraspinal tumors (23 cases, 85.19%). The histological diagnosis of tumors included embryonic residual tumors (6 cases, 22.22%), ependymoma (5 cases, 18.52%), primitive neuroectodermal tumors (PNET) (3 cases, 11.11%), schwannomas (2 cases, 7.4%), ganglioneuroma (1 case, 3.7%), Ewing’s sarc (1 case, 3.7%), B-cell non Hodgkin lymphoma (1 case, 3.7%), Hodgkin lymphoma (1 case, 3.7%), chondrosarcoma (1 case, 3.7%), ganglioglioma (1 case, 3.7%), and glioma (1 case, 3.7%). Conclusions: The incidence of pediatric intraspinal space-occupying lesions is low, and the clinical manifestation is lack of specificity. The prognosis for children with malignant tumors is poor and surgical resection is still the primary treatment option.

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“…RT has an important role in the palliative treatment of pediatric spinal tumors with pain relief in up to 83% of treated patients, with 43% able to decrease their daily dose of opioids. 12,13 Potential factors limiting the use of palliative RT in children may be the logistics involved in treatment, especially if multiple sessions are required.…”

Section: Discussionmentioning

confidence: 99%

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

Cardarelli-Leite

Rassekh

D'Ortenzio

et al. 2021

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Primary and secondary malignant tumors of the spine are relatively uncommon in the pediatric population but are associated with high morbidity and significantly decreased quality of life due to pain. Local management of these tumors is often challenging due to the importance of maintaining vertebral mechanical integrity as well as the spinal growth potential. Typically, surgery and/or radiation therapy have been used in the primary management of these tumors. However, treatment options become more limited when there is relapse or refractory disease, with re-resection or additional radiotherapy often not being viable therapies. Vertebroplasty is a currently underutilized modality that might provide significant pain palliation in cases of relapsed cancer in the spine.

show abstract

Treatment patterns of children with spine and spinal cord tumors: national outcomes and review of the literature

Cited by 11 publications

References 32 publications

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

Intraspinal Space-Occupying Lesions in Children: Clinical Features, Neuroimaging and Surgical Outcomes of 27 Cases

Vertebroplasty as a palliative treatment option for intractable pain in pediatric patients with spinal tumors

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