Treatment planning considerations for 125I eye plaque brachytherapy

Abstract

Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general procedures and strategies for optimization and customization of the plaques loaded with radioactive seeds, particularly focusing on the definition of useful tactics to limit high doses to organs at risk and adapt the treatment time to the necessity of institution.

Distribution modeling of nanoparticles for brachytherapy of human eye tumor

“…It is proposed that a dose rate of 0.60 to 1.05 Gy/h delivers the total dose in 3 to 10 consecutive days [ 31 ]. To avoid the damage to the critical structures such as optic nerve, the dose ranging between 30 and 60 Gy has been suggested in the literature [ 32 , 33 ].…”

Radiobiological evaluation of organs at risk for electronic high-dose-rate brachytherapy in uveal melanoma: a radiobiological modeling study

“…Treatment of uveal melanomas includes enucleation or radiation therapy. Radiation therapy may be delivered either via brachytherapy (BT) [4][5][6][7][8][9][10][11][12][13][14][15][16][17], external beam radiation therapy (EBRT), using proton beams or stereotactic radiosurgery with Gamma knife (Elekta Instruments, Stockholm, Sweden). Outcomes [18] are reported in terms of survival, metastases, recurrence, and visual acuity, but there are few EBRT results that include doses to OARs within the optical apparatus [19][20][21].…”