In this paper, possibilities of laser fluorescence spectroscopy to predict the reactions of the oral cavity cancer to radiation treatment are considered. A theoretically substantiated assumption about the link between the tumor's consumption of an exogenous photosensitizer and its radioresistance is proposed. The first experience with the use of the Radahlorin photosensitizer is described; preliminary results of the 5 patients study are presented. As a result different photosensitizer consumptions versus different treatment outcomes are discussed.