Treatment potential of normobaric hypoxic therapy in therapeutic and pediatric practice

Игнатенко, Г. А.; Dubovaya, A. V.; Naumenko, Yu. V.

doi:10.21508/1027-4065-2022-67-6-46-53

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…В настоящее время внимание медицинского сообщества привлекают альтернативные методы лечения и реабилитации, направленные на активацию адаптационных механизмов при различных патологических процессах [1,2]. Одним из наиболее распространенных и эффективных методов немедикаментозного лечения сердечно-сосудистых, бронхолегочных, цереброваскулярных и других заболеваний является гипокситерапия, инициирующая увеличение реактивности организма, повышение чувствительности органов-мишеней к действию внешних и внутренних раздражителей [3][4][5][6][7].…”

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Molecular and Cellular Mechanisms of Hypoxic Response

Bondarenko,

Khomutov,

Ryapolova

et al. 2023

Ulyanovsk Medico-biological Journal

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Hypoxia is a typical pathological process characterized by oxygen tissue deficiency with the pathological and protective-compensatory reactions. The article briefly outlines the issues of hypoxia study and interval hypoxic training in clinical and rehabilitation practice while treating various diseases and pathological processes. The authors consider types of physiological and pathological responses to hypoxia, key aspects in the pathogenesis of normo- and hypobaric hypoxia under normal and reduced atmospheric pressure, and stages of hypoxia development. Physiological and biochemical responses to interval hypoxic training are associated with oxidative stress, which develops as a result of an imbalance between the pro- and antioxidant systems, and excessive production of reactive oxygen species. Interval hypoxic training is aimed at adequate activation of defense systems with the formation of stable adaptation to damaging factors. The authors prove the key role of HIF-1α biological effects in the mechanisms of cellular and tissue adaptation to oxygen deficiency. The authors also analyze the role of adenosine and adenosine receptors in acute and chronic inflammatory diseases associated with tissue hypoxia.

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Molecular and Cellular Mechanisms of Hypoxic Response

Bondarenko,

Khomutov,

Ryapolova

et al. 2023

Ulyanovsk Medico-biological Journal

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Impact of hypoxia on the immune system

Ignatenko,

Prilutskiy,

Bondarenko

et al. 2024

jour

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Hypoxia is a condition that occurs when there is a decrease in the normal level of oxygen due to a decrease in the availability or delivery of this gas to cells and tissues. It is important to note that hypoxic conditions occur in many diseases. With a low oxygen content in tissues and cells, numerous physiological and pathological changes occur. The article summarizes information from the scientific literature on the effect of hypoxia on the immune system. The analysis shows that the lack of oxygen has a significant effect on the regulation of the immune response. This influence is mediated by a family of factors induced by hypoxia. Among them, the most studied is HIF-1α. The action of factors is carried out by various mechanisms. The influence of factors induced by hypoxia was registered in the analysis of the function of all cells of natural and acquired immunity.

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Mechanisms of Vasoprotection and Cardioprotection in Hypoxytherapy of Arterial Hypertension and Coronary Artery Disease

Ignatenko

2024

Kompleks. probl. serdečno-sosud. zabol.

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Highlights The article presents a modern understanding of the main links of the functional circulatory regulation system and its response to exogenous hypoxia, as well as describes the data available on molecular mechanisms of vasoprotection and cardioprotection involved in response to hypoxytherapy in patients with arterial hypertension and coronary artery disease. AbstractHypoxic conditioning has taken an important place in the range of non-drug methods for stimulating the adaptive potential of a healthy person and patients with cardiovascular diseases. There are many approaches to the use of various methods of exogenous hypoxia, however, there is no consensus on the essence of sanogenetic mechanisms that provide a multi-level functional system for maintaining oxygen supply and blood circulation. Adaptive reactions of afferent, central and efferent links of the functional circulatory regulation system in hypoxia in a healthy person are described. The results of studies of physiological systemic reactions realized by respiratory and vegetative plasticity using interval (intermittent) hypoxia are presented. In patients with arterial hypertension and coronary artery disease, the facts of chemoreflective stimulation and modulation of lung ventilation, autonomic nervous system status, especially sympathetic activity of peripheral blood vessels and vagal activation of cardiac activity have been established. The main vaso- and cardioprotective properties of interval hypoxytherapy are based on the leveling of oxidative stress, inflammation, activation of angiogenesis, and a shift in the secretory activity of the endothelium towards vasodilating, antiproliferative, and antithrombotic mediators. We present the evidence for the role of shear stress and the state of glycocalyx, angiopoietin and adrenomedulline in the regulation of vascular tone, as well as cytoprotective properties of cytoplasmic and mitochondrial metabolic factors in the formation of ischemic tolerance of cardiomyocytes. The issues of the relationship between systemic (neuronal and humoral) reactions and structural and functional responses of target cells in providing adaptive/compensatory mechanisms for regulating blood circulation under the influence of exogenous hypoxia require further research and evaluation.

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Treatment potential of normobaric hypoxic therapy in therapeutic and pediatric practice

Cited by 7 publications

References 6 publications

Molecular and Cellular Mechanisms of Hypoxic Response

Molecular and Cellular Mechanisms of Hypoxic Response

Impact of hypoxia on the immune system

Mechanisms of Vasoprotection and Cardioprotection in Hypoxytherapy of Arterial Hypertension and Coronary Artery Disease

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