Treatment Regimens for <i>Helicobacter pylori</i> Infection in Children: Is <i>In Vitro</i> Susceptibility Testing Helpful?

Faber, J.; Bar-Meir, Maskit; Rudensky, Bernard; Schlesinger, Yechiel; Rachman, Elena; Benenson, Shmuel; Sirota, Gisela; Stankiewic, Halina; Halle, David; Wilschanski, Michael

doi:10.1097/01.mpg.0000155567.71902.75

Cited by 37 publications

(36 citation statements)

References 31 publications

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“…There is very limited information on the impact of clarithromycin and metronidazole resistance on H. pylori eradication in children. We have identified few clinical trials over the last two decades which evaluate the clinical outcome of H. pylori triple therapies with respect to pre-treatment susceptibility testing to clarithromycin and metronidazole (16,19,(43)(44)(45)(46). Despite the very limited number and power of pediatric clinical trials including susceptibility testing, the effect of resistance on treatment outcome was more pronounced for clarithromycin than for metronidazole (Table II).…”

Section: Factors Affecting Eradication Ratementioning

confidence: 99%

Helicobacter Pylori Therapy in Children: Overview and Challenges

Chiesa

Pacifico

Anania

et al. 2010

Int J Immunopathol Pharmacol

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Helicobacter pylori is one of the most common infections found in humans. It was first identified in 1982 and by 1989 had been associated with gastric inflammation and ulcers in adults and children. During the 1990's evidence emerged of its etiologic role in stomach cancers in adults. That the infection is common and may have serious consequences, has led to an avalanche of research during the last twenty years. During this time, there have been many studies on children which have sought an effective and safe treatment to eradicate the infection, but as yet, no therapy regimen has been found which is always effective and safe. This article provides information, from a pediatric point of view, on the major developments in the therapeutics and therapy of H. pylori infection. It examines first-line treatment regimens, evaluates the efficacy of the main drugs used in the management of (primary) H. pylori infection in children, assesses the potential for the use of probiotics and sequential therapy, examines therapeutic options after failure of initial treatment, and discusses factors affecting eradication rate, including antibiotic resistance, adherence to therapy, and bacterial factors.

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Section: Factors Affecting Eradication Ratementioning

confidence: 99%

Helicobacter Pylori Therapy in Children: Overview and Challenges

Chiesa

Pacifico

Anania

et al. 2010

Int J Immunopathol Pharmacol

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“…Many global studies have been published comparing the effectiveness of different regimens in the eradication of H. pylori [7][8][9][10][11]; however there are no data reporting the efficacy of our regimens in routine clinical practice. Considering the fact that H. pylori cure rates vary in different geographical regions because of differences in hosts as well as in H. pylori strains [7], we decided to carry out this study to evaluate the efficacy of the treatment regimens used in our clinics for eradication of H. pylori, in order to select a treatment regimen that is most effective with the least adverse effects and cost.…”

Section: Introductionmentioning

confidence: 98%

Efficacy of the Standard Quadruple Therapy Versus Triple Therapies Containing Proton Pump Inhibitor Plus Amoxicillin and Clarithromycin or Amoxicillin-Clavulanic Acid and Metronidazole for Helicobacter pylori Eradication in Children

et al. 2008

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“…Beside (8) Many literature reported that eradication therapy just give real effect in H. pylori infection with peptic ulcer. Since this time, the patient never have abdominal pain and vomit symptom.…”

Section: Discussionmentioning

confidence: 99%

“…(11) Faber etc at the research in Israrel showed eradication was achieved in 73,4% by omeprazole + amoxicillin with metronidazole and in 62,6% by omeprazole + amoxicillin with claritromycin (p=0,078). (8) Good nutrition is very important for growth and developmental of children, also attack diseases. Optimal intake dietary of is the patient necessary to protect severe problem of nutrition.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter Pylori Infection in Children

Jurnalis¹,

Sayoet²,

Dewi³

2011

MKA

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AbstrakFaktor risiko infeksi Helicobacter pylori adalah tinggal di negara berkembang, kondisi sosial ekonomi yang rendah, jumlah anggota keluarga yang banyak, etnik dan genetik. Tatalaksana dan diagnosis Helicobacter pylori belum memuaskan karena adanya resistensi antibiotik pada pasien Helicobacter pylori. Kami melaporkan seorang pasien perempuan usia 8 tahun 6 bulan yang terinfeksi Helicobacter pylori. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan hasil laboratorium. Pasien diduga terinfeksi Helicobacter pylori karena mengalami nyeri perut berulang. Dari laboratorium didapatkan serologi IgG Helicobacter pylori positif. Pada hasil endoskopi biopsi ditemukan kuman Helicobacter pylori. Pasien mendapat therapi eradikasi lini pertama untuk infeksi Helicobacter pylori yaitu amoksisilin, klaritromisin dan omeprazol selama dua minggu. Setelah dua minggu pengobatan keluhan pasien tidak ada. Kata kunci: Helicobacter pylori, anak, nyeri perut berulang Abstract Risk factors for acquiring Helicobacter pylori infection include residency of developing country, poor socioeconomic conditions, crowded family, and possibly an ethnic or genetic as predispositions. The diagnosis and management Helicobacter pylori has not been satisfied yet, however, there is problem of increasing resistancy antibiotic due to Helicobacter pylori. Objective: We report a 8 year and 6 month old girl who suffered from Helicobacter pylori. The diagnosis was based on history, clinical finding, and laboratory work-up. Suspicion on the presence of Helicobacter pylori was started when the girl had recurrent abdominal pain. Serology IgG Helicobacter pylori was positive and we had done endoscopic examination and biopsy. Therapy this patient was first line eradication Helicobacter pylori which give amoxicillin, clarithromycin and omeprazole for two weeks. There are no sympthoms after two weeks therapy Key word: Helicobacter pylori, children, recurrent abdominal pain LAPORAN KASUS

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Treatment Regimens for Helicobacter pylori Infection in Children: Is In Vitro Susceptibility Testing Helpful?

Cited by 37 publications

References 31 publications

Helicobacter Pylori Therapy in Children: Overview and Challenges

Helicobacter Pylori Therapy in Children: Overview and Challenges

Efficacy of the Standard Quadruple Therapy Versus Triple Therapies Containing Proton Pump Inhibitor Plus Amoxicillin and Clarithromycin or Amoxicillin-Clavulanic Acid and Metronidazole for Helicobacter pylori Eradication in Children

Helicobacter Pylori Infection in Children

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