Treatment related factors associated with the risk of breast radio-induced-sarcoma

Mirjolet, Céline; Diallo, Ibrahima; Bertaut, Aurélie; Veres, Cristina; Sargos, P.; Helfre, Sylvie; Sunyach, Marie‐Pierre; Truc, G.; Péchoux, C. Le; Paumier, A.; Ducassou, A.; Jolnerovski, Maria; Thariat, Juliette; Lapeyre, M.; Cordoba, Abel; Mahé, M.‐A.; Maingon, P.

doi:10.1016/j.radonc.2022.04.004

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…However, radiotherapy also involves limitations comprising radio-induced toxicities on healthy surrounding tissues and an increase in the risk of developing radio-induced cancer following an exposition to a high dose of radiation [ 10 , 11 ]. Moreover, radiotherapy remains limited for tumors difficult to target or those requiring high doses of radiation, such as radioresistant cancers, which often leads to decreased therapeutic outcomes and cancer reoccurrence [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of core-shell Fe3O4@Au nanoparticles as radioenhancer in A549 cell lung cancer model

Slama,

Arcambal,

Septembre-Malaterre

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Evaluation of core-shell Fe3O4@Au nanoparticles as radioenhancer in A549 cell lung cancer model

Slama,

Arcambal,

Septembre-Malaterre

et al. 2024

Heliyon

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“…Radiation-induced sarcomas are predominantly angiosarcomas (48.1–57.9%) ( 6 , 8 ). Radiation-induced liposarcomas are even rarer and accounts for 2.4% of all radiation-induced sarcomas ( 9 ). Herein, we report a rare case of radiation-induced pleomorphic liposarcoma after breast-conserving surgery and hypofractionated irradiation and a literature review.…”

Section: Introductionmentioning

confidence: 99%

Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review

Watanabe,

Tokiya,

Kawata

et al. 2024

Oncol Lett

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Breast cancer is one of the leading causes of cancer globally. Radiotherapy following breast-conserving surgery is the standard treatment of breast cancer. Recently, hypofractionated irradiation comprising 42.56 Gy in 16 fractions was selected as a viable radiation therapeutic option. Radiation-induced sarcoma is the most prevalent secondary malignancy in patients undergoing radiotherapy after breast cancer surgery. Angiosarcomas are the predominant type of radiation-induced sarcomas, whereas liposarcomas have rarely been reported. The present report details an uncommon instance of radiation-induced pleomorphic liposarcoma that occurred 8 years after breast-conserving surgery and hypofractionated radiotherapy. The patient visited the hospital due to hardening of the tissue beneath the skin of the right breast. Ultrasonography revealed a hypoechoic mass in the lower part of the right breast containing internal blood flow. An excisional biopsy revealed that the tumor contained infiltrating spindle-shaped cells without a capsule containing pleomorphic cells. Lipoblasts were also observed and tended to differentiate into adipose tissue, leading to a diagnosis of pleomorphic liposarcoma. Immunostaining revealed negativity for cytokeratin AE1/AE3, ERG, MDM2 and S-100 protein; the Ki-67 index was ~20%. An enlargement resection involving a postoperative bed was performed because of close tumor margins. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography revealed pale accumulation of 18 F-fluorodeoxyglucose in the right chest wall, which was interpreted as a postoperative change owing to the resection biopsy. The tumor was observed in the irradiated field with no distant metastases. Following extensive resection, the patient maintained a recurrence-free survival period of 3 years and 2 months, during which no adjuvant therapy was administered. Therefore, follow-up is necessary in patients with breast cancer treated with radiotherapy.

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“…A collaborative group of early breast cancer trialists reported a ratio of rates of 2.34 (2 p = 0.03) of soft-tissue sarcoma after radiation in their meta-analysis [ 6 ]. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review

Hoshina

Kubouchi²,

Tsutsumi

et al. 2023

surg case rep

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Background Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2–0.27% and a poor prognosis, although the radiation should need for breast-conserving surgery. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS. Case presentation A 43-year-old woman with pT1N1M0 breast cancer underwent breast-conserving surgery, chemotherapy, radiation therapy 8 years ago, and continued hormonal therapy. She complained of a hard unprotruded mass palpated in her right upper outer quadrant of breast. Although we suspected local recurrence, core needle biopsy revealed atypical spindled tumor cells without mammary or epithelial markers. A diagnosis of fibrosarcoma was made via tumorectomy. She underwent additional enlarged surgery. Conclusions We report a rare case of fibrosarcoma in breast after breast-conserving surgery and radiation therapy. Fibrosarcoma after radiation therapy for breast cancer has been reported in 30 cases, including the present case. The dead and alive cases were not significantly different in terms of age, primary breast cancer, radiation dose, and following months. Patients with breast masses after radiation therapy should be suspected local recurrence and RIS.

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Treatment related factors associated with the risk of breast radio-induced-sarcoma

Cited by 11 publications

References 35 publications

Evaluation of core-shell Fe3O4@Au nanoparticles as radioenhancer in A549 cell lung cancer model

Evaluation of core-shell Fe3O4@Au nanoparticles as radioenhancer in A549 cell lung cancer model

Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review

Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review

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