Treatment-resistant depression with anhedonia: Integrating clinical and preclinical approaches to investigate distinct phenotypes

Synergic action of L-acetylcarnitine and L-methylfolate in Mouse Models of Stress-Related Disorders and Human iPSC-Derived Dopaminergic Neurons

“…This novel form of intervention is predicted to be effective in the management of patients with TRD, in which non-monoaminergic drugs have better chances of success. Our findings lay the groundwork for an in-depth analysis of the synergism between LAC and MF in additional preclinical models, such as 1) models that are able to identify groups of animals resilient to both acute ( Torrisi et al, 2020 ) and chronic ( Dziedzicka-Wasylewska et al, 2021 ) stress; 2) models in which LAC and MF are combined with subthreshold doses of conventional antidepressants (e.g., SSRIs or SNRIs); and, 3) experimental animal models of TRD, characterized by a reduced or absent response to antidepressants ( Planchez et al, 2019 ; Kelly et al, 2022 ).…”

Transdiagnostic Psychiatry: Symptom Profiles and Their Direct and Indirect Relationship With Well-Being

“…Mood shows the clustering of multiple dimensions of depression, instead of a distinction between i.e. depressed mood and anhedonia, which is known to have poorer prognosis (Kelly et al, 2022). The self-image profile, however, may have the highest transdiagnostic value, because it is composed of at least one item of every questionnaire.…”

Subcallosal area 25: Its responsivity to the stress hormone cortisol and its opposing effects on appetitive motivation in marmosets

“…Moreover, intervention studies in marmoset monkeys provide evidence for the causal role of overactivation of area 25 within caudal scACC (scACC-25) in the symptoms of depression and anxiety. Specifically, scACC-25 overactivation induces anticipatory and motivational anhedonia ( Alexander et al, 2018 ), a major symptom of depression and especially common in treatment resistant patients ( Kelly et al, 2022 ; Słupski et al, 2020 ). It also heightens reactivity to uncertain threat, causes generalisation of conditioned threat responses and increases sympathetic cardiovascular activity alongside reduced heart rate variability ( Alexander et al, 2020 ); symptoms commonly reported in generalised anxiety disorder ( Hur et al, 2020 ; Pittig et al, 2013 ).…”