Treatment Response in Type 2 Diabetes Patients with Major Depression

Góis, Carlos; Dias, Vasco Videira; Carmo, Isabel do; Duarte, Rita Carolina Figueiredo; Ferro, Ana; Santos, Ana Isabel; Sousa, Filomena; Barbosa, António

doi:10.1002/cpp.1817

Cited by 25 publications

(21 citation statements)

References 46 publications

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“…With regard to the effects of HFD, only one study reported that unpredictable chronic mild stress-induced behavioural changes were all reversed by fluoxetine in STD-fed mice but not in HFDfed mice (Isingrini et al, 2010). SSRI non-response in T2DM is also supported by a number of clinical studies showing associations between low rates of remission with SSRI treatment and T2DM (Anderson et al, 2010;Bryan et al, 2010;Gois et al, 2014). At the molecular levels, it is possible that the basal hypersensitivity of the 5-HT 1A autoreceptor played an important role in the escitalopram non-response by hindering its ability to enhance 5-HT levels in the hippocampus.…”

Section: Figurementioning

confidence: 99%

“…These pharmacological agents, including escitalopram or sertraline, are effective in treating MD in patients with T2DM (Williams et al, 2007;Gehlawat et al, 2013). However, other clinical studies have led to the opposite conclusions (Anderson et al, 2010;Gois et al, 2014), as a significant proportion of patients with T2DM suffering from MD do not achieve remission with SSRI treatment. Among the factors that might explain such a non-response to antidepressant drugs, patient age, the severity of the psychiatric/metabolic disorder or the ability of 5-HT related antidepressant drugs to further destabilize glucose homeostasis (Ghaeli et al, 2004;Raeder et al, 2006;Williams et al, 2007) are possible explanations.…”

Section: Introductionmentioning

confidence: 99%

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High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Zemdegs

Quesseveur

Jarriault

et al. 2015

British J Pharmacology

143

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BACKGROUND AND PURPOSEThe link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic-like/depressive-like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients. EXPERIMENTAL APPROACHMice were fed a high-fat diet (HFD) and subjected to a full comprehensive metabolic and behavioural analysis to establish correlations between metabolic and psychiatric disorders. In vivo intra-hippocampal microdialysis was also applied to propose a mechanism underpinning the phenotype of mice fed the HFD. Finally, we tested whether chronic administration of the selective 5-HT reuptake inhibitor escitalopram or HFD withdrawal could reverse HFD-induced metabolic and behavioural anomalies. KEY RESULTSThe increased body weight, hyperglycaemia and impaired glucose tolerance in response to HFD were correlated with anxiogeniclike/depressive-like symptoms. Moreover, this phenotype was associated with decreased extracellular 5-HT levels in the hippocampus which may result from increased sensitivity of the dorsal raphe 5-HT 1A autoreceptor. Interestingly, the beneficial effect of prolonged administration of escitalopram was abolished in HFD-fed mice. On the contrary, HFD withdrawal completely reversed metabolic impairments and positively changed symptoms of anxiety, although some behavioural anomalies persisted. CONCLUSIONS AND IMPLICATIONSOur data provide clear-cut evidence that both pathologies are finely correlated and associated with impaired 5-HT mediated neurotransmission in the hippocampus. Further experiments are warranted to define the most adequate strategy for the treatment of such co-morbidity. LINKED ARTICLES

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Zemdegs

Quesseveur

Jarriault

et al. 2015

British J Pharmacology

143

View full text Add to dashboard Cite

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“…As early as the 1980s, psychotherapy researchers have observed that the bulk of symptomatic improvement occurs within the 1st month of therapy, with 60% of total improvement in cognitive behavioral therapy for depression occurring by Week 4 (Rush, Kovacs, Beck, Weissenburger, & Hollon, ). Since then, numerous other studies have reported early response patterns across different mental health problems and psychological therapies (Bell, Waller, Shafran, & Delgadillo, ; Bradford et al, ; Delgadillo et al, ; Doyle, Le Grange, Loeb, Doyle, & Crosby, ; Gois et al, ; Hunnicutt‐Ferguson, Hoxha, & Gollan, ; Rubel et al, ).…”

Section: Introductionmentioning

confidence: 99%

Early response to psychological therapy as a predictor of depression and anxiety treatment outcomes: A systematic review and meta‐analysis

Beard

Delgadillo

2019

Depress Anxiety

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Background Previous studies indicate that early symptomatic improvement, typically observed during the first 4 weeks of psychological therapy, is associated with positive treatment outcomes for a range of mental health problems. However, the replicability, statistical significance, and magnitude of this association remain unclear. Aim The current study reviewed the literature on early response to psychological interventions for adults with depression and anxiety symptoms. Methods A systematic review and random effects meta‐analysis were conducted, including studies found in Medline, PsychINFO, SCOPUS, Web of Science, and through reference lists and reverse citations. Results Twenty‐five eligible studies including 11,091 patients measured early response and examined associations with posttreatment outcomes. It was possible to extract and/or calculate effect size data from 15 studies to conduct a meta‐analysis. A large pooled effect size (g = 0.87 [95% confidence interval: 0.63–1.10], p < .0001) indicated that early responders had significantly better posttreatment outcomes compared to cases without early response, and this effect was larger in anxiety (g = 1.37) compared to depression (g = 0.76) measures. Most studies were of good quality and there was no evidence of publication bias. The main limitations concerned insufficient statistical reporting in some studies, which precluded their inclusion in meta‐analysis, and it was not possible to examine effect sizes according to different outcome questionnaires. Conclusion There is robust and replicated evidence that early response to therapy is a reliable prognostic indicator for depression and anxiety treatment outcomes.

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“…Since then, numerous randomized controlled trials have shown that IPT is indeed effective in the treatment of depression (3), that it may be more effective than other psychotherapies for depression (4,5), that it may prevent relapse after successful treatment of depression (3), that it may prevent the onset of major depressive disorders in those with subthreshold depression (6), and that it is also effective in specific target groups, such as adolescents (7,8), older adults (9), and patients with a somatic disorder (10)(11)(12).…”

mentioning

confidence: 99%

Interpersonal Psychotherapy for Mental Health Problems: A Comprehensive Meta-Analysis

Cuijpers¹,

Donker²,

Weissman³

et al. 2016

AJP

244

146

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Objective: Interpersonal psychotherapy (IPT) has been developed for the treatment of depression but has been examined for several other mental disorders. A comprehensive meta-analysis of all randomized trials examining the effects of IPT for all mental health problems was conducted.Method: Searches in PubMed, PsycInfo, Embase, and Cochrane were conducted to identify all trials examining IPT for any mental health problem.Results: Ninety studies with 11,434 participants were included. IPT for acute-phase depression had moderate-to-large effects compared with control groups (g=0.60; 95% CI=0.45-0.75). No significant difference was found with other therapies (differential g=0.06) and pharmacotherapy (g=-0.13). Combined treatment was more effective than IPT alone (g=0.24). IPT in subthreshold depression significantly prevented the onset of major depression, and maintenance IPT significantly reduced relapse. IPT had significant effects on eating disorders, but the effects are probably slightly smaller than those of cognitive-behavioral therapy (CBT) in the acute phase of treatment. In anxiety disorders, IPT had large effects compared with control groups, and there is no evidence that IPT was less effective than CBT. There was risk of bias as defined by the Cochrane Collaboration in the majority of studies. There was little indication that the presence of bias influenced outcome.Conclusions: IPT is effective in the acute treatment of depression and may be effective in the prevention of new depressive disorders and in preventing relapse. IPT may also be effective in the treatment of eating disorders and anxiety disorders and has shown promising effects in some other mental health disorders.

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Treatment Response in Type 2 Diabetes Patients with Major Depression

Cited by 25 publications

References 46 publications

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Early response to psychological therapy as a predictor of depression and anxiety treatment outcomes: A systematic review and meta‐analysis

Interpersonal Psychotherapy for Mental Health Problems: A Comprehensive Meta-Analysis

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