Treatment results and prognostic factors in oral tongue cancer: analysis of 80 patients

Aksu, Görkem; Karadeniz, Aslı; Saynak, Mert; Fayda, Merdan; Kadehci, Z.; Kocaelli, Hümeyra

doi:10.1016/j.ijom.2006.01.006

Cited by 42 publications

(29 citation statements)

References 30 publications

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“…Our study showed that advanced T classification (T3–4), positive nodal metastasis (N1–3) and poorly differentiated tumor predicted poor survival for all patients, which were compatible with previous studies (Aksu et al, 2006; Goto et al, 2005; Liao et al, 2008). The male patients showed significantly poor survival than the female patients for all patients, but showed no significant difference after dividing all patients into early and advanced stages.…”

Section: Discussionsupporting

confidence: 92%

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Tsai

Lai

Lee

et al. 2016

PeerJ

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BackgroundOur study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups.MethodsFrom 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions constituting the Chang Gung Memorial Hospitals (CGMH). We divided and studied the patients in three age groups: Group 1, younger (<65 years); Group 2, young old (65 to <75); and Group 3, older old patients (≥75 years).ResultsMultivariate analyses determined the unfavorable, independent prognostic factors of overall survival to be male sex, older age, advanced stage, advanced T, N classifications, and surgery plus chemotherapy. No significant differences were found in adjusted hazard ratios (HR) of death in early-stage disease (stage I–II) among Group 1 (HR 1.0), Group 2 (HR 1.43, 95% confidence interval (CI) [0.87–2.34], p = 0.158), and Group 3 (HR 1.22, 95% CI [0.49–3.03], p = 0.664) patients. However, amongst advanced-stage patients (stage (III–IV)), Group 3 (HR 2.53, 95% CI [1.46–4.38], p = 0.001) showed significantly worse survival than the other two groups after other variables were adjusted for. Fourteen out of 21 older old, advanced-staged patients finally died, and most of the mortalities were non-cancerogenic (9/14, 64.3%), and mostly occurred within one year (12/14, 85%) after cancer diagnosis. These non-cancer cause of death included underlying diseases in combination with infection, pneumonia, poor nutrition status, and trauma.ConclusionsOur study showed that advanced T classification (T3–4), positive nodal metastasis (N1–3) and poorly differentiated tumor predicted poor survival for all patients. Outcome of early-stage patients (stage I–II) among three age groups were not significantly different. However, for advanced-stage patients (stage III–IV), the older old patients (≥75) had significantly worse survival than the other two patient groups. Therefore, for early-stage patients, age should not deny them to receive optimal treatments. However, older old patients (≥75) with advanced cancer should be comprehensively assessed by geriatric tools before surgical treatment and combined with intensive postoperative care to improve outcome, especially the unfavorable non-cancerogenic mortalities within one year after cancer diagnosis.

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Section: Discussionsupporting

confidence: 92%

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Tsai

Lai

Lee

et al. 2016

PeerJ

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“…O tratamento preconizado para o câncer de boca envolve diferentes modalidades terapêuticas, tais como: a cirurgia, a radioterapia e a quimioterapia, e depende também da localização, do grau de malignidade e do estadiamento do tumor, assim como, das condições físicas do paciente (9)(10) . Em princípio o tratamento de escolha para as neoplasias avançadas inclui sempre procedimentos cirúrgicos associados à radioterapia (10)(11) . A despeito dos avanços das técnicas de diagnóstico e tratamento, a sobrevida dos pacientes portadores de neoplasias de cabeça e pescoço tem aumentado apenas marginalmente.…”

Section: Introductionunclassified

Identificação das mudanças na mastigação e deglutição de indivíduos submetidos à glossectoma parcial

Oliveira

Vieira

Mota

et al. 2008

Rev. soc. bras. fonoaudiol.

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OBJETIVO: Identificar as alterações de mastigação e deglutição decorrentes da cirurgia curativa do câncer de língua, com extensão inferior a 50% da dimensão da língua e sem comprometimento do soalho da boca e da base da língua. MÉTODOS: Foram realizadas avaliações das funções de mastigação e deglutição em nove pacientes, seis homens e três mulheres, no período pré-operatório, aplicando-se um protocolo específico. No pós-operatório mediato, três semanas após a cirurgia, cinco pacientes foram reavaliados, quatro homens e uma mulher, seguindo o mesmo protocolo. Para verificar a significância dos resultados foi utilizado o teste não paramétrico de Kruskall Wallis (Teste H). RESULTADOS: Comparando-se os achados do pré-operatório com os achados do pós-operatório encontramos, de forma significativa (p<0,05), mudança da via de alimentação, que passou de uma alimentação exclusivamente oral, para uma alimentação exclusivamente enteral. Também houve mudança significativa na eficiência mastigatória, que passou a ser ineficiente em todos os pacientes. Percebeu-se, de forma significativa, a dificuldade dos pacientes em manipular o bolo alimentar durante o processo de mastigação, gerando dificuldade na formação de um bolo coeso. Isso demonstra que a cirurgia influencia na realização desta função, ou seja, a perda de parte da língua compromete o processo de mastigação. A deglutição também foi prejudicada pela cirurgia, uma vez que o teste demonstrou de forma significativa a presença de estase oral, após a deglutição e movimentos compensatórios de cabeça para a deglutição de alimentos sólidos. CONCLUSÃO: Os pacientes submetidos à glossectomia parcial apresentam mudanças na mastigação e deglutição decorrentes do tratamento cirúrgico.

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“…The most prevalent clinical stage of this tumour at time of presentation is T2N0, which is observed in approximately 35% of cases 1,4 .…”

mentioning

confidence: 99%

Unilateral, clinically T2N0, squamous cell carcinoma of the tongue: surgical outcome analysis

Lim

Choi

2007

International Journal of Oral and Maxillofacial Surgery

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Treatment results and prognostic factors in oral tongue cancer: analysis of 80 patients

Cited by 42 publications

References 30 publications

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Identificação das mudanças na mastigação e deglutição de indivíduos submetidos à glossectoma parcial

Unilateral, clinically T2N0, squamous cell carcinoma of the tongue: surgical outcome analysis

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