Treatment results of 84 patients with nasopharyngeal carcinoma in childhood

Abstract

The cisplatin-based regimen was the best chemotherapeutic regimen. Less toxic regimens with better survival rates should be investigated in patients with nasopharyngeal carcinoma.

Endocrine Complications Following Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma

“…This study has also showed that clinical hypothyroidism occurred more frequently in younger patients, female sex and following conformal radiotherapy. Some reports have also suggested a higher incidence of radiationinduced hypothyroidism in the younger age group treated for Hodgkin's disease (Shalet et al, 1977) or for NPC (Zubizarreta et al, 2000), while other reports did not (Daoud et al, 2003;Kupeli et al, 2006). These rates of radiation-induced hypothyroidism are significantly higher than the reported rates of 0.3-1.3% in the general population (Wu et al, 2010).…”

5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice

“…In recent years, clinical studies have demonstrated effectiveness of 5-FU on pediatric tumors, such as low-grade gliomas, nasopharyngeal carcinoma and hepatoblastoma (Casanova et al, 2012;Kupeli et al, 2006;Lee et al, 2006;Rodriguez-Galindo et al, 2005). The previous studies, including experimental and clinical reports, have suggested that 5-FU could result in oligodendrocytes (OLs) injury and reversible white-matter degeneration in adult patients (Cho et al, 2004;Fujimoto et al, 2006;Han et al, 2008;Ishibashi et al, 2004;Newton 2012;Sioka and Kyritsis, 2009).…”

Hypothyroidism After Radiotherapy for Nasopharyngeal Cancer Patients

“…For example, in the study by Zubizarreta et al (23), 8 (73%) of 11 young NPC patients developed hypothyroidism by follow-up at a median of 63 months. However, Daoud et al (24) reported that 14% of 32 pediatric NPC patients developed hypothyroidism, and Kupeli et al (25) found that 9.5% of 84 patients developed hypothyroidism. The lower incidences of hypothyroidism reported in these studies may be due to limitations in their retrospective designs.…”