Treatment Satisfaction and Its Associated Factors of Dolutegravir Based Regimen in a Resource Limited Setting

Mehari, Eden Abetu; Muche, Esileman Abdela; Gonete, Kedir Abdela; Shiferaw, Kirubel Biruk

doi:10.2147/ppa.s308571

Cited by 5 publications

(1 citation statement)

References 51 publications

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“…The Joint United Nations Program on HIV/AIDS (UNAIDS) recommends that 95% of PLHIV on ART should be virally suppressed (1), which necessitates optimal ART adherence (9). Studies in Africa report a DTG suboptimal adherence of 16%-53% (10,11); associated with unemployment and younger age (13-24) (10), understanding counseling about patient treatment (12); discussion with a healthcare provider (13), response after disclosure, and medicine re ll intervals (11). The Ugandan ART adherence level is still suboptimal; at 93% (14), versus the 95% target by 2025 (15).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda

Namakula,

Mugerwa,

Kitutu

et al. 2023

Preprint

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Background Suboptimal adherence to dolutegravir is up to 31% globally. In Uganda, 54% of people living with HIV(PLHIV) on first-line Antiretroviral Therapy (ART) were taking dolutegravir-based regimens. This study aimed to determine the prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens in PLHIV in a specialized clinic in Uganda. Methods We conducted a cross-sectional study with both quantitative and qualitative aspects in a specialized HIV clinic in Kampala, Uganda, from July 2022 to August 2022. We collected quantitative data, using questionnaires, and data abstraction tools; from 366, consecutively sampled, and consented PLHIV. We collected qualitative data using in-depth interviews, among 13 purposively sampled, consented participants. We analyzed quantitative data using modified Poisson regression in STATA, to obtain factors associated with suboptimal adherence at the 5% level of significance. Qualitative data was analyzed using thematic analysis in Open Code. Results The prevalence of suboptimal adherence to dolutegravir-based regimens was 49% (179/366; 95%Confidence Interval (CI): 44–54). Alcohol consumption (adjusted Prevalence Ratio (aPR): 1.25; 95%CI: 1.012–1.543), being unemployed (aPR: 1.27; 95%CI: 1.002–1.609), not having neighbor’s support (aPR: 0.78; 95%CI: 0.619–0.993), and participants who preferred to talk to the doctor in case of a health problem (aPR: 0.44; 95%CI: 0.307–1.270) were associated with suboptimal adherence, to dolutegravir-based ART regimens. Barriers to dolutegravir adherence included: unemployment, lack of social support, alcohol consumption, and inadequate counselling. Conclusion Suboptimal adherence to dolutegravir-based ART was high. PLHIV should start-up projects that are economically viable. Dolutegravir-related virological failure in PLHIV should be investigated.

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Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda

Namakula,

Mugerwa,

Kitutu

et al. 2023

Preprint

View full text Add to dashboard Cite

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The Role of Patient-Reported Outcomes to Measure Treatment Satisfaction in Drug Development

Navas,

Minton,

Rodriguez-Leboeuf

2024

Patient

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Treatment satisfaction is a person’s rating of his or her treatment experience, including processes and outcomes. It is directly related to treatment adherence, which may be predictive of treatment effectiveness in clinical and real-world research. Consequently, patient-reported outcome (PRO) instruments have been developed to incorporate patient experience throughout various stages of drug development and routine care. PRO instruments enable clinicians and researchers to evaluate and compare treatment satisfaction data in different clinical settings. It is important to select fit-for-purpose PRO instruments that have demonstrated adequate levels of reliability, validity, and sensitivity to change to support their use. Some of these instruments are unidimensional while some are multidimensional; some are generic and can be applied across different therapeutic areas, while others have been developed for use in a specific treatment modality or condition. This article describes the role of treatment satisfaction in drug development as well as regulatory and Health Technology Assessment (HTA) decision making and calls for more widespread use of carefully selected treatment satisfaction PRO instruments in early- and late-phase drug development.

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Unraveling patient satisfaction, associated factors, and dissatisfaction reasons in the provision of health care services for rural communities in Bangladesh: A cross-sectional investigation

Siddique,

Nath,

Mohammad Rasel

et al. 2024

Clinical Epidemiology and Global Health

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Treatment Satisfaction and Its Associated Factors of Dolutegravir Based Regimen in a Resource Limited Setting

Cited by 5 publications

References 51 publications

Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda

Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda

The Role of Patient-Reported Outcomes to Measure Treatment Satisfaction in Drug Development

Unraveling patient satisfaction, associated factors, and dissatisfaction reasons in the provision of health care services for rural communities in Bangladesh: A cross-sectional investigation

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