Treatment satisfaction and medication adherence among hypertensive patients in a teaching hospital in Ekiti State, Nigeria

Akpor, OluwaseyiAbiodun; Olowolaju, FlorenceOlutola

doi:10.4103/jin.jin_4_22

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Hypertension is defined by the World Health Organization [ 6 ] as persistently elevated systolic blood pressure greater than 140 mmHg and diastolic pressure greater than 90 mmHg. Although hypertension is preventable, it is still a major public health problem globally, its prevalence has been increasingly rising [ 11 , 12 ]. Hypertension ranks first among the preventable causes of death worldwide and the number of patients with hypertension continues to increase in developing countries every year [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although hypertension is preventable, it is still a major public health problem globally, its prevalence has been increasingly rising [ 11 , 12 ]. Hypertension ranks first among the preventable causes of death worldwide and the number of patients with hypertension continues to increase in developing countries every year [ 11 , 13 ]. The prevalence also varies by ethnicity, with African Americans having the highest prevalence [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Treatment expectation among patients with diabetes and hypertension in a tertiary hospital, Ekiti State, Southwest Nigeria: a cross-sectional study

Adeoye¹,

Akpor²,

Oguntola³

et al. 2023

Pan Afr Med J

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Introduction patients' satisfaction is an important aspect in determining the quality of health care since it reveals how staff are progressing toward the patients' objectives. Objective: the study determined the treatment perception and expectations among diabetes and hypertensive patients in a teaching hospital in Ekiti State, Nigeria. Methods the study employed a cross-sectional design approach with a sample size of 200 participants. Descriptive analyses were used to answer the research questions while inferential statistics were used to test hypotheses at a significant level of p < 0.05. Results the findings revealed that 50% (n=196) and 57.1% (n=196) of the patients with diabetes and hypertension were above 60 years with mean age and standard deviation being 3.36 ± 0.72, while 63.3% (n=196) and 64.3% (n=196) of the patients with diabetes and hypertension were females. Overall, the results revealed a significant difference between the domains of participants´ expectations and perceptions, with the expectations domains being significantly higher for both diabetes and hypertensive patients with mean score and standard deviation being (-5.14 (±1.62) and -4.55 (±1.83)) respectively. However, the difference in the gap scores between the participants with diabetes and those with hypertension across the domains of patients´ expectations and perceptions was significant. Furthermore, apart from the tangible domain 19.76 (±0.87) (p < 0.05), the findings from the study showed that participants with diabetes had significantly higher expectation scores, when compared with those with hypertension in all domains. Additionally, the participants with diabetes showed the highest level of perception in the tangible 15.75 (±1.43) and empathy 20.50 (±1.20) domains while those with hypertension showed the highest level of perception in the reliability, responsiveness, and assurance domains (21.66 (±2.45), 16.58 (±1.38) and 21.43 (±2.03) p < 0.001 respectively). Conclusion efforts should be intensified by nurses and all other stakeholders to exceed patients´ expectations by continually improving the quality of health care and services offered to patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment expectation among patients with diabetes and hypertension in a tertiary hospital, Ekiti State, Southwest Nigeria: a cross-sectional study

Adeoye¹,

Akpor²,

Oguntola³

et al. 2023

Pan Afr Med J

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High burden of non-adherence to blood pressure-lowering medications: meta-analysis of data from over 34,000 adults with hypertension in Sub-Saharan Africa

Aminde,

Agbor,

Fongwen

et al. 2024

Preprint

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Introduction: Non-adherence to blood pressure (BP)-lowering medication is a strong predictor of poor BP control. Sub-Saharan Africa (SSA) has extremely low BP control rates (~10%), but it is unclear what the burden of medication non-adherence among Africans with hypertension is. This systematic review estimated the prevalence and determinants of non-adherence to BP-lowering medications in SSA. Methods: Multiple databases were searched from inception to 6 December 2023. Two reviewers performed independent screening, extraction, and quality assessment of studies. We pooled the prevalence estimates using random effects meta-analyses and summarized the determinants using a narrative synthesis. Results: From the 1,307 records identified, we included 95 studies published between 1995 and 2023. The overall prevalence of non-adherence to BP-lowering medication among 34,102 people treated for hypertension in 27 countries was 43.5% (95% confidence interval 39.4 to 47.6; I2 = 98.3%). There was no change in the prevalence of non-adherence over time. The burden of non-adherence varied by measurement method (p = 0.028) and by median age (38.8%, > 57 years vs. 47.9%, ≤ 57 years; p = 0.015). Socioeconomic and patient-related factors were the most frequent factors that influenced medication adherence. Active patient participation in management, accurate perceptions, and knowledge of hypertension and its treatment predicted good medication adherence, whereas high pill burden, medication cost, side effects, and comorbidities predicted poor adherence. Conclusions: With the African population projected to increase from 1.4 to ~2.5 billion by 2050, targeted strategies are urgently needed to optimise medication adherence in people with hypertension in SSA.

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AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension: A retrospective analysis

Yu,

Li,

Wei

et al. 2024

Asian Pacific Journal of Tropical Medicine

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Objective: To investigate whether angiotensin II type 1 receptor (AGTR1 A1166C) gene polymorphism was associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension. Methods: This retrospective analysis included 198 patients (⩾18 years of age) who received valsartan monotherapy (80 mg/day) for newly developed essential hypertension at the authors’ center between January 1, 2020 and December 31, 2023. Genotyping for AGTR1 A1166C gene polymorphism was done by polymerase chain reaction (PCR)-melting curve analysis of genomic DNA from peripheral blood samples. A dominant genetic model for AGTR1 A1166C (AA genotype versus AC + CC genotype) was used. Multivariate regression analysis of baseline variables and AGTR1 polymorphism was conducted to identify predictors of target blood pressure attainment (<140/90 mmHg) at the 4-week follow-up. Results: The median age of the 198 patients was (53.7±13.5) years, and 58% were men. Genotyping assays showed that 164 patients had the AA genotype, and 34 patients were of the AC/CC genotype, including 30 with the AC genotype and 4 with the CC genotype. Allele distribution was consistent with Hardy Weinberg equilibrium. 109 Patients (55.1%) attained the blood pressure target. Multivariate analysis showed that smoking (versus no smoking, HR 0.314, 95% CI 0.159-0.619, P=0.001) and AGTR1 A1166C AA genotype (versus AC/CC, HR 2.927, 95% CI 1.296-6.611, P=0.023) were significant and independent predictors of target attainment. 25 Patients (73.5%) with AGTR1 A1166C AC/CC genotype attained the target versus 51.2% (51/164) of patients with AGTR1 A1166C AA genotype (P=0.017). Patients with AGTR1 A1166C AC/CC genotype had a significantly greater reduction in systolic blood pressure [(33.1±10.8) mmHg versus (29.2±11.7) mmHg in AA carriers; P=0.029)]. Conclusions: Hypertensive patients carrying one or two C alleles of the AGTR1 A1166C gene were more responsive to valsartan treatment.

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Treatment satisfaction and medication adherence among hypertensive patients in a teaching hospital in Ekiti State, Nigeria

Cited by 3 publications

References 15 publications

Treatment expectation among patients with diabetes and hypertension in a tertiary hospital, Ekiti State, Southwest Nigeria: a cross-sectional study

Treatment expectation among patients with diabetes and hypertension in a tertiary hospital, Ekiti State, Southwest Nigeria: a cross-sectional study

High burden of non-adherence to blood pressure-lowering medications: meta-analysis of data from over 34,000 adults with hypertension in Sub-Saharan Africa

AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension: A retrospective analysis

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