Treatment strategies for and outcomes of older patients with oral squamous cell carcinoma

Yamada, Shin‐ichi; Kitamura, Hiroshi; Nakano, Ryuichi; Ohta, Ryosuke; Akita, Daisuke; Hashidume, Masao; Morishita, Kota; Kondo, Eiji; Sakai, Hironori

doi:10.1016/j.oooo.2019.10.009

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…In addition, there are more adverse drug reactions due to aging organ functions than younger patients. Hence, it has been suggested that different treatment strategies should be given to the young and the old [ 7 ]. In this paper, we made a survival analysis based on information of patients with oral squamous cell carcinoma in different ages.…”

Section: Introductionmentioning

confidence: 99%

Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER

Yang,

Guo,

Zhang

et al. 2023

Eur J Med Res

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Background This research aimed to investigate the prognostic factors of oral squamous cell carcinoma (OSCC), especially the role of age. Methods A total of 33,619 cases of OSCC were received from the Surveillance, Epidemiology, and End Results (SEER) database during 2005–2015. Kaplan–Meier curves of 5-year overall survival rates and 5-year cancer-specific survival rates were performed, and univariate and multivariate Cox regression analyses as well as competing risk model were used to help understand the relationship between various factors and mortality of OSCC. Results Compared to 18–39-year-old group, the older age was an important predictor of worse prognosis. The multivariate analysis of overall survival (OS) was 50–59 years (HR, 1.32; 95% CI 1.17–1.48; p ≤ .001), 60–69 years (HR, 1.66; 95% CI 1.42–1.87; p ≤ .001) and 70 + years (HR, 3.21; 95% CI 2.86–3.62; p ≤ .001), respectively, while the specific value of competing risk model was 60–69 years (HR, 1.21; 95% CI 1.07–1.38; p = .002) and 70 + years (HR, 1.85; 95% CI 1.63–2.10; p ≤ .001). In addition, female gender, unmarried, Blacks, tumor in floor of mouth, size and higher Tumor Node Metastasis (TNM) classification were also other predictors that signify significant clinically deterioration of OS/cancer-specific survival (CSS). Conclusions Our research revealed that age was an important factor in explaining the difference of survival in the whole process of OSCC. It is suggested that we should pay attention to the influence of age on diagnosis, treatment and prognosis in the clinical process.

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Section: Introductionmentioning

confidence: 99%

Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER

Yang,

Guo,

Zhang

et al. 2023

Eur J Med Res

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show abstract

“…Also, there are more adverse drug reactions due to aging organ functions than younger patients. Hence it has been suggested that different treatment strategies should be given to the young and the old 7 . In this paper, we made a survival analysis based on information of patients with oral squamous cell carcinoma in different ages.…”

Section: Introductionmentioning

confidence: 99%

Survival Analysis of Age-related Oral Squamous Cell Carcinoma: A Population Study Based on SEER

Wang¹,

Guo²,

Zhang³

et al. 2021

Preprint

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This research aimed to investigate the prognostic factors of oral squamous cell carcinoma (OSCC), especially the role of age. A total of 33619 cases of OSCC were received from the Surveillance, Epidemiology, and End Results database during 2005–2015. Kaplan-Meier curves of 5-year overall survival rates and 5-year cancer specific survival rates were performed, and univariate and multivariate Cox regression analysis as well as competing risk model were used to help understand the relationship between various factors and mortality of OSCC. Compared to 18–39 years old group, the older age was an important predictor of worse prognosis. The multivariate analysis of overall survival (OS) were 50–59 years old (HR, 1.32; 95% CI, 1.17–1.48; p ≤ .001), 60–69 years old (HR, 1.66; 95% CI, 1.42–1.87; p ≤ .001) and 70 + years old (HR, 3.21; 95% CI, 2.86–3.62; p ≤ .001) respectively, while the specific value of competing risk model were 60–69 years old (HR, 1.21; 95% CI, 1.07–1.38; p = .002) and 70 + years old (HR, 1.85; 95% CI, 1.63–2.10; p ≤ .001). In addition, female gender, unmarried, Blacks, tumor in floor of mouth, size and higher TNM classification were also other predictors that signify significant clinically deterioration of OS / CSS. Our research revealed that age was an important factor in explaining the difference of survival in the whole process of OSCC. It’s suggested that we should pay attention to the influence of age on diagnosis, treatment and prognosis in the clinical process.

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The clinical impact of the G8 screening tool score on treatment strategy decisions and outcomes among oral squamous cell carcinoma patients aged 75 years or older in Japan

Yamada,

Hasegawa,

Yamakawa

et al. 2024

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Treatment strategies for and outcomes of older patients with oral squamous cell carcinoma

Cited by 8 publications

References 24 publications

Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER

Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER

Survival Analysis of Age-related Oral Squamous Cell Carcinoma: A Population Study Based on SEER

The clinical impact of the G8 screening tool score on treatment strategy decisions and outcomes among oral squamous cell carcinoma patients aged 75 years or older in Japan

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