Treatment Strategies for Reducing the Burden of Menopause-Associated Vasomotor Symptoms

Umland, Elena

doi:10.18553/jmcp.2008.14.s3-a.14

Cited by 47 publications

(51 citation statements)

References 15 publications

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“…This finding supports other recent studies on soy and phytoestrogens. 55,93,94 A recent experimental study by D'Anna et al 95 discusses the effects of the phytoestrogen genistein. They reported a shortterm positive effect (up to 1 year) of genistein in reduction of HFs.…”

Section: Soy Isoflavones and Phytoestrogensmentioning

confidence: 99%

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Ziv‐Gal¹,

Flaws

2010

Journal of Women's Health

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Background: Interest in menopausal symptoms in general and hot flushes (HFs) in particular has grown in recent years. This is mostly due to increased awareness and the vast impact these symptoms have on women's lives. Despite the high prevalence of women who experience HFs, a definitive etiology for HFs is yet to be found. Our objective was to review the current literature dealing with associated factors for experiencing HFs and to provide a synthesized overview on this common and often debilitating condition. Methods: We systematically searched the English-language literature in the PubMed database using relevant key words and included only those articles that contained information on associated factors for HFs in generally healthy midlife women. Results: Both conflicting scientific results between studies documenting factors that influence HFs and the lack of validated measuring tools make it difficult to truly pinpoint associated factors for HFs. Nonetheless, we identified the following clusters of associated factors: the menopausal stages, sex steroid hormones, other endocrine agents, genetic polymorphisms, race=ethnicity, body mass index (BMI) and obesity, mood disorders, smoking, soy isoflavones and phytoestrogens, alcohol consumption, and physical activity. Conclusions: No single associated factor was consistently identified as having a major role in experiencing HFs. More resources should be directed to develop a unified study system along with multivariable analyses to get a better understanding of this condition, which often imposes a tremendous social and personal toll on the women who experience it.

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Section: Soy Isoflavones and Phytoestrogensmentioning

confidence: 99%

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Ziv‐Gal¹,

Flaws

2010

Journal of Women's Health

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“…3 Hot flushes are the commonest 4 and the most troublesome symptoms during the menopausal transition. 3,5 Most women complain of symptoms lasting for 6 months to 2 years, though approxi mately 10% have symptoms persis ting for a decade or longer. 3,6 Vasomotor symptoms is the leading menopausal symptom presenting for medical attention.…”

Section: 5005/jp-journals-10032-1063mentioning

confidence: 99%

“…6 The prevalence of VMS varies considerably among ethnicities and menopausal status. 5,7 Postmenopausal women show a higher prevalence than pre-or perimenopausal women, and Afro-Americans report a greater prevalence than other ethnic groups. 7 Hot flushes increase with older age, smoking, low educational status, anxiety states and depression.…”

Section: 5005/jp-journals-10032-1063mentioning

confidence: 99%

“…7 Hot flushes increase with older age, smoking, low educational status, anxiety states and depression. 5,8 Increase in body mass index (BMI) show contrasting associations with VMS, with studies showing both higher 1,5,9 and lower 8 incidence.…”

Section: 5005/jp-journals-10032-1063mentioning

confidence: 99%

“…3,11 Decrease in circulating serotonin, increase in norepinephrine and decrease in estrogen concentrations are implicated in narrowing of the thermoneutral range. 5,11 This leads to exaggerated heat loss response, where increased peripheral vascular reactivity causes vasodilatation causing sweating and skin flushing which manifests as hot flushes. 3,15 Estrogen acts as a potent neuromodulatory agent in the hypothalamic thermoregulatory center, and decli ning estrogen concentrations lead to alterations in hypothalamic neurotransmitter activity, especially in the serotonergic and noradrenergic pathways.…”

Section: Effects On the Hypothalamic Thermoregulatory Centermentioning

confidence: 99%

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Vasomotor Symptoms: What is the Impact of Physical Exercise?

Atapattu¹

2015

JSAFOMS

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Vasomotor symptoms (VMS) or hot flushes are the commonest and the most troublesome symptoms during the menopausal transition. Though usually transient, VMS is the leading menopausal symptom presenting for medical attention. Hormone replacement therapy (HRT) is the most effective treatment for VMS, but many women are reluctant to use HRT and wish to pursue alternative therapy.Physical exercise of different types has been used as a mean of alleviating VMS. The potential for physical exercise to improve VMS can be explained by its effects on the postulated pathophysiologcal mechanisms of VMS. However, individual studies on the influence of physical exercise on VMS show conflicting results, with positive, negative or no effects being reported, and the review of evidence is inconclusive. The many differences in the study designs may be a reason for the varying outcomes of the studies.Physical exercise, however, have multiple benefits in postmenopausal women, in reducing cardiovascular risk factors, improving bone density and preventing osteoporosis, enhan cing muscle mass and has a positive effect on overall health. Regular physical activity should, therefore, be promoted in all postmenopausal women, though they may not derive a significant improvement of VMS.

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Weight management and its role in breast cancer rehabilitation

Demark‐Wahnefried¹,

Campbell²,

Hayes³

2012

Cancer

198

154

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Overweight and obesity are risk factors for post-menopausal breast cancer, and many women diagnosed with breast cancer, irrespective of menopausal status, gain weight after diagnosis. Weight management plays an important role in rehabilitation and recovery since obesity and/or weight gain may lead to poorer breast cancer prognosis, as well as prevalent co-morbid conditions (e.g. cardiovascular disease and diabetes), poorer surgical outcomes (e.g., increased operating and recovery times, higher infection rates, and poorer healing), lymphedema, fatigue, functional decline, and poorer health and overall quality of life. Health care professionals should encourage weight management at all phases of the cancer care continuum as a means to potentially avoid adverse sequelae and late effects, as well as to improve overall health and possibly survival. Comprehensive approaches that involve dietary and behavior modification, and increased aerobic and strength training exercise have shown promise in either preventing weight gain or promoting weight loss, reducing biomarkers associated with inflammation and comorbidity, and improving lifestyle behaviors, functional status, and quality of life in this high-risk patient population.

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Treatment Strategies for Reducing the Burden of Menopause-Associated Vasomotor Symptoms

Cited by 47 publications

References 15 publications

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Vasomotor Symptoms: What is the Impact of Physical Exercise?

Weight management and its role in breast cancer rehabilitation

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