Treatment strategies, including antibiotics, to target the immune component of rosacea

Delans, Kristen; Kelly, Katherine A.; Feldman, Steven R.

doi:10.1080/1744666x.2022.2128334

Cited by 8 publications

(11 citation statements)

References 90 publications

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“…8 Oral and topical antibiotics, lifestyle modification, immunomodulatory agents, and laser-and light-based therapies are commonly used to treat this disorder, although the literature indicates limited utility, considerable commitment from patients, frustration with outcomes, lack of adherence, and serious side effects. [20][21][22][23][24] Several studies have explored the pathogenesis of rosacea, and our understanding of the cutaneous biology of the disease has evolved considerably. 25 Specifically, several biologic aberrancies appear to contribute to the development of rosacea, including tolllike receptors, 26,27 kallikrein-related peptidase 5 and cathelicidin LL-37, 28 nuclear factor κB, 29 myeloid differential factor-88, 30 and multiple genetic factors.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple therapeutic options are routinely employed to address rosacea, because each modality suffers from incomplete responses and adverse events 8 . Oral and topical antibiotics, lifestyle modification, immunomodulatory agents, and laser‐ and light‐based therapies are commonly used to treat this disorder, although the literature indicates limited utility, considerable commitment from patients, frustration with outcomes, lack of adherence, and serious side effects 20–24 …”

Section: Discussionmentioning

confidence: 99%

“… 8 Oral and topical antibiotics, lifestyle modification, immunomodulatory agents, and laser‐ and light‐based therapies are commonly used to treat this disorder, although the literature indicates limited utility, considerable commitment from patients, frustration with outcomes, lack of adherence, and serious side effects. 20 , 21 , 22 , 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

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Safety and tolerability of topical trametinib in rosacea: Results from a phase I clinical trial

Wladis,

Busingye,

Saavedra

et al. 2024

Skin Health and Disease

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PurposeOveractivation of the mitogen activated kinase pathway has been associated with rosacea. We hypothesised that inhibitors of this pathway can be repurposed to alleviate rosacea symptoms.MethodsIn order to test this hypothesis, we designed a double‐blind, randomised, placebo‐controlled phase I clinical trial to assess the safety and tolerability of a first‐in‐kind topical formulation of a MEK kinase inhibitor, trametinib. Subjects applied daily trametinib‐containing cream (0.05 mg in 0.5 mL) to one cheek and cream without inhibitor to the other for consecutive 21 days. Skin irritation scores and blood samples were obtained during visits on days 8, 15 and 22.ResultsOn analysis of high‐performance liquid chromatography, no systemic trametinib absorption was detected during this treatment period. Subjects demonstrated a slight but significant improvement in both cheeks, regardless of drug contents. No adverse effects were reported during this time.ConclusionsTopical trametinib was well tolerated at a dose of 0.05 mg per day without meaningful systemic absorption or local adverse events. A dose escalation trial is warranted to determine optimal dosing to treat rosacea while avoiding the adverse effects of systemic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Safety and tolerability of topical trametinib in rosacea: Results from a phase I clinical trial

Wladis,

Busingye,

Saavedra

et al. 2024

Skin Health and Disease

View full text Add to dashboard Cite

show abstract

“… 10 Moreover, the current treatment for rosacea, topical brimonidine, obtains poor efficacy. 14 To explore whether serum GLA level could influence the efficacy of topical brimonidine, the authors also investigate the predictive value of serum GLA levels for the prognosis of rosacea using a linear regression model. Mechanically, the regression analysis identified that GLA level is a predictive factor for the prognosis of rosacea, with higher GLA levels accompanied by better clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Associations of serum gamma-linolenic acid levels with erythema severity and anxiety/depression status in patients with rosacea

Tang,

Chen,

Wan

et al. 2024

Anais Brasileiros de Dermatologia

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“…In rosacea, they are thought to contribute to chronic inflammation and vascular dysfunction ( 29 ). Recent advancements underscore the pivotal role of macrophages in rosacea’s pathophysiology ( 30 ). Macrophages, acting as scavengers, clear body debris and microbes and are essential for wound healing, tissue repair, and resolving skin inflammation ( 31 ).…”

Section: The Role Of Macrophages In Skin and Rosaceamentioning

confidence: 99%

The role of macrophages in rosacea: implications for targeted therapies

Liu,

Zhou,

Chu

et al. 2023

Front. Immunol.

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IntroductionRosacea, a widespread chronic skin condition, may be influenced by macrophages, key immune cells in the skin, although their exact role is not yet fully understood. This review delves into the function of macrophages, their potential contribution to rosacea pathogenesis, current treatments, and promising macrophage-targeted therapies. It concludes by identifying knowledge gaps and potential areas for future rosacea research.MethodLeveraging systematic and narrative literature review techniques, we conducted a comprehensive search of databases such as PubMed, Embase, and Web of Science. Utilizing keywords like “rosacea” and “macrophages”, we targeted English articles from the last 5 years (2018-2023). We manually checked reference lists of relevant articles for additional studies. We included only articles emphasizing macrophages’ role in rosacea and/or the development of related therapies and published within the specified timeframe.ResultsThe systematic search of electronic databases yielded a total of 4,263 articles. After applying the inclusion and exclusion criteria, 156 articles were selected for inclusion in this review. These articles included original research studies, review articles, and clinical trials that focused on the role of macrophages in rosacea and/or the development of macrophage-targeted therapies for the disease. The selected articles provided a comprehensive and up-to-date overview of the current state of research on macrophages in rosacea, including their function in the skin, the potential mechanisms through which they may contribute to rosacea pathogenesis, and the current treatments and therapies available for the disease. Additionally, the articles identified gaps in knowledge regarding the role of macrophages in rosacea and suggested potential areas for future research.ConclusionThis literature review emphasizes the important role that macrophages, vital immune cells in the skin, may play in the pathogenesis of rosacea, a common chronic inflammatory skin disorder. The selected studies suggest potential mechanisms by which these cells might contribute to rosacea progression, although these mechanisms are not yet fully understood. The studies also spotlight current rosacea treatments and illuminate the promising potential of new macrophage-focused therapies. Despite these insights, significant gaps persist in our understanding of the precise role of macrophages in rosacea. Future research in this area could provide further insights into the pathogenesis of rosacea and contribute to the development of more effective, targeted therapeutic strategies.

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Treatment strategies, including antibiotics, to target the immune component of rosacea

Cited by 8 publications

References 90 publications

Safety and tolerability of topical trametinib in rosacea: Results from a phase I clinical trial

Safety and tolerability of topical trametinib in rosacea: Results from a phase I clinical trial

Associations of serum gamma-linolenic acid levels with erythema severity and anxiety/depression status in patients with rosacea

The role of macrophages in rosacea: implications for targeted therapies

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