2007
DOI: 10.1007/s00432-007-0297-7
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Treatment strategies that effectively reduce early recurrence risk in postmenopausal women with endocrine-sensitive breast cancer: AIs upfront vs. switching

Abstract: Several large, well-controlled clinical trials have now established that the aromatase inhibitors (AIs), including letrozole, anastrozole, and exemestane, are more effective than tamoxifen when used as adjuvant endocrine therapy in postmenopausal women with breast cancer. Yet, it is an open question as to how these drugs should be best integrated into the adjuvant treatment regimen. Both letrozole and anastrozole have shown efficacy over tamoxifen when used as initial adjuvant therapy (initiated just following… Show more

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Cited by 3 publications
(1 citation statement)
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“…Currently, the local recurrence rate after breast cancer surgery, as reported by both foreign and domestic reports, ranges from 4.0% to 32.05%. The chest wall is the most common site of recurrence, and accounts for 50.0-94.0% of all local recurrences (Brewster et al, 2007;Paepke et al, 2007;Dinh et al, 2008;Fodor et al, 2008;Pennery, 2008). There are multiple factors resulting in postoperative chest wall recurrence of breast cancer, which may be related to local infiltration of the primary focus and lymph node metastatic focus, postoperative cancer cell residue, generalized dissemination of cancer cells to local tissues, and possibly operation type (Herrinton et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Currently, the local recurrence rate after breast cancer surgery, as reported by both foreign and domestic reports, ranges from 4.0% to 32.05%. The chest wall is the most common site of recurrence, and accounts for 50.0-94.0% of all local recurrences (Brewster et al, 2007;Paepke et al, 2007;Dinh et al, 2008;Fodor et al, 2008;Pennery, 2008). There are multiple factors resulting in postoperative chest wall recurrence of breast cancer, which may be related to local infiltration of the primary focus and lymph node metastatic focus, postoperative cancer cell residue, generalized dissemination of cancer cells to local tissues, and possibly operation type (Herrinton et al, 2005).…”
Section: Discussionmentioning
confidence: 99%