2021
DOI: 10.1007/s40368-021-00669-4
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Treatment time, pain experience and acceptability of the technique for caries removal in primary teeth using the ART approach with or without Brix3000™ papain gel: a preliminary randomised controlled clinical trial

Abstract: Purpose To compare the Atraumatic Restorative Treatment (ART) associated with Brix3000™ to ART considering treatment time, pain experienced, and acceptability to children. Methods This study was accepted in Research Ethics Committee in July 2019 (number 3469402). Healthy patients ( n = 20) aged 3–9 years, with at least one primary molar with occlusal dentine caries without cusp involvement were randomly allocated to either the ART + Brix3000™ … Show more

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Cited by 4 publications
(11 citation statements)
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References 24 publications
(29 reference statements)
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“…Out of the 56 texts, 30 were excluded due to the following reasons: irrelevance ( n = 2), non-randomized controlled trial ( n = 2), no retrieval of English full text ( n = 7), registered protocol only ( n = 1), reporting oral health-related quality of life ( n = 8), clinical success ( n = 5), subjects were adolescents (1) or with special healthcare needs (1) and caregiver-reported outcomes ( n = 3). Subsequently, only 26 [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] studies were included for the final qualitative and quantitative analysis and data extraction (Kappa k: 1) ( Supplementary Table S2 ). A summary of the PRISMA flowchart [ 50 ] for identification and screening the eligibility of the papers, final inclusion of the studies and reasons for exclusion are illustrated in Figure 1 .…”
Section: Resultsmentioning
confidence: 99%
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“…Out of the 56 texts, 30 were excluded due to the following reasons: irrelevance ( n = 2), non-randomized controlled trial ( n = 2), no retrieval of English full text ( n = 7), registered protocol only ( n = 1), reporting oral health-related quality of life ( n = 8), clinical success ( n = 5), subjects were adolescents (1) or with special healthcare needs (1) and caregiver-reported outcomes ( n = 3). Subsequently, only 26 [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] studies were included for the final qualitative and quantitative analysis and data extraction (Kappa k: 1) ( Supplementary Table S2 ). A summary of the PRISMA flowchart [ 50 ] for identification and screening the eligibility of the papers, final inclusion of the studies and reasons for exclusion are illustrated in Figure 1 .…”
Section: Resultsmentioning
confidence: 99%
“…Ultimately, the 26 included studies [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] represented 4699 participants from 5 Asian countries [ 34 , 37 , 38 , 43 , 45 ], 1 Australasian country [ 29 ], 8 European countries [ 14 , 27 , 31 , 35 , 42 , 46 , 47 , 48 ], 11 Southern American countries [ 25 , 26 , 28 , 30 , 32 , 33 , 39 , 40 , 41 , 44 , 49 ] and 1 African country […”
Section: Resultsmentioning
confidence: 99%
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“…ART avoids the unnecessary use of rotary instruments and local anesthesia, which reduces patient distress, anxiety and fear [16] . It is performed using a sharp hand instrument to remove the decayed tooth structure, followed by restoration with ionomer [7] .…”
Section: Atraumatic Restorative Treatment (Art)mentioning
confidence: 99%
“…The technique consists of removing the decomposed tissue by applying natural or synthetic agents to dissolve and facilitate the removal of the infected tissue [23] . Papain promotes proteolysis of the collagen fibrils exposed in the decayed tissue, which further softens the decayed tissue, facilitating its removal with hand instruments [16] . After use, the gel often changes color and becomes cloudy or produces bubbles, making it easier to identify the reaction, completion or absence (i.e., no decomposed tissue remains) [25] .…”
Section: Papacariementioning
confidence: 99%