Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

Abstract

Purpose-Recent advances in head and neck cancer (HNC) treatment, such as increased use of organ-preserving advanced radiation treatments, the approval of cetuximab for HNC treatment, and the increase in human papillomavirus (HPV)-related HNC, have changed clinical approaches to HNC management. We sought to identify treatment trends in a population-based cohort of HNC patients. Methods-The Surveillance, Epidemiology, and End Results Patterns of Care program collected additional treatment and HPV testing information on stratified random samples of HNC patients diagnosed in 1997 (n=473), 2004 (n=1,317), and 2009 (n=1,128). Rao-Scott chi-square tests were used to examine unadjusted associations between year of diagnosis and patient sociodemographic, tumor, and treatment characteristics. Cochran-Armitage tests for trend were used to examine the hypothesis that certain treatments were used increasingly (or decreasingly) over the time period, while logistic regression was used to examine factors associated with particular treatments. Results-Use of radiation and chemotherapy without surgery significantly increased for all HNC sites between 1997 and 2009. Cetuximab and taxane use also showed a significantly increasing trend. Lack of insurance was associated with not receiving treatment in multivariate models. The majority (64%) of cases undergoing radiation in 2009 received an advanced treatment, with 55% receiving intensity modulated. The majority of oropharyngeal cases with known HPV status received chemotherapy and radiation only (62%) and nearly all were insured and had one or fewer co-morbidities. Conclusions-Treatment patterns have changed for HNC, leading to increased incorporation of systemic therapy and newer radiation techniques. HPV testing should be targeted for more widespread use, especially in traditionally underserved groups.

Head and neck cancer surgery during the COVID‐19 pandemic: An international, multicenter, observational cohort study

“…In the United States, 2009 data from the Surveillance, Epidemiology, and End Results database showed that 82% of OC cancers, 28% of OP cancers, and 32% of L cancers were treated with primary surgery. 36 An analysis of National Cancer Data Base figures from 2004 to 2013 shows that for T1/T2 OP cancers, the rate of primary surgery rose from 56% in 2004 to 82% in 2013. 37 In Spain, data from Madrid illustrate that in 2017, 74% of OC cancers, 34% of OP cancers, and 71% of L cancers were treated with surgery.…”

Cervical Fibrosis as a Predictor of Dysphagia

“…Head and neck cancer is the sixth most common cancer worldwide 1 . Radiotherapy with or without chemotherapy is an increasingly utilized potentially curative treatment that can afford organ preservation 2 . Radiotherapy causes repeated damage to effected tissue at the cellular and extracellular levels resulting in abnormal wound healing 3 …”

Methionine synthase A2756G polymorphism associated with an increased risk of head and neck cancer

“…21,26 In our study we found that the incidence of HNSCC is more in age groups 41-50 years and >60 years as previously reported. 27 This finding suggests aging factor should be considered as risk factor for onset of HNSCC. One study reported that incidence of oral cancer has been increased while frequency of pharyngeal cancer has been reduced for the past few years in many populations worldwide.…”