Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate

Satoh, Masataka; Oyama, Noritaka; Yamada, Hitoshi; Nakamura, Koichiro; Kaneko, Fumio

doi:10.1111/j.1346-8138.2008.00438.x

Cited by 21 publications

(9 citation statements)

References 9 publications

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“…Non‐steroidal anti‐inflammatory agents and corticosteroids may be useful as palliative drugs but they do not seem to induce remission 18 or modify the outcome of the disease 6 . Some patients have been reported to achieve remission with methotrexate, chlorambucil or cyclophosphamide 18–21 …”

Section: Discussionmentioning

confidence: 99%

Multicentric reticulohistiocytosis with elevated cytokine serum levels

Bennàssar

Mas

Guilabert

et al. 2011

The Journal of Dermatology

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Multicentric reticulohistiocytosis (MRH) is an uncommon non-Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor-α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate-resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.

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Section: Discussionmentioning

confidence: 99%

Multicentric reticulohistiocytosis with elevated cytokine serum levels

Bennàssar

Mas

Guilabert

et al. 2011

The Journal of Dermatology

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“…Les bisphosphonates, en particulier l'alendronate, ont peut être une place car cette molécule pourrait agir sur les monocytes/macrophages par la voie des mévalonates en s'accumulant dans le réticulum endoplasmique de ces cellules. Ainsi, ils ont aussi un effet anti-inflammatoire sur les arthrites [13,14]. Récemment, les anti-TNF-alpha ont été proposés avec une certaine efficacité [15].…”

Section: Discussionunclassified

La réticulohistiocytose multicentrique : une affection auto-immune systémique ? À propos d’une forme associée à une polyarthrite rhumatoïde érosive et un syndrome de Sjögren systémique

Abdelghani¹,

Mahmoud²,

Chatelus³

et al. 2010

Revue du Rhumatisme

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“…One patient with diffuse cutaneous RHC was successfully treated with 8‐methoxypsoralen ultraviolet A photochemotherapy (PUVA) 6 . The use of methotrexate, alone or in combination with other systemic drugs, has been reported 1,7 . Because of our patient’s photosensitivity and positive ANA titres, we felt PUVA was not appropriate.…”

Section: Reportmentioning

confidence: 94%

“…6 The use of methotrexate, alone or in combination with other systemic drugs, has been reported. 1,7 Because of our patient's photosensitivity and positive ANA titres, we felt PUVA was not appropriate. We decided to use methotrexate as first-line treatment, and saw a marked clinical improvement at the end of 6 months.…”

Section: Reportmentioning

confidence: 95%

Reticulohistiocytosis: different dermatoscopic faces and a good response to methotrexate treatment

Kaçar

Taşlı

Argenziano

et al. 2010

Clinical and Experimental Dermatology

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The reticulohistiocytoses are a rare group of non-Langerhans cell histiocytic disorders. Recently, dermatoscopic features have been reported for some of the xanthomatous disorders. We report a case of diffuse cutaneous reticulohistiocytosis with 29 reticulohistiocytomas. On dermatoscopy of these lesions, we saw three typical features: a homogeneous pattern with various shades of yellow (defined previously as a 'setting-sun' pattern), brown reticular structures, and central white scar-like patches and streaks. The setting-sun pattern was most commonly seen in combination with brown reticular structures. In four lesions, brown reticular structures surrounded a central white scar-like patch resembling that of a dermatofibroma. However, the presence of the setting-sun pattern in the background gave a different hue to that of the peripheral network seen in a dermatofibroma. A marked clinical improvement was associated with 6 months of systemic methotrexate treatment. Dermatoscopy may aid in the diagnosis of xanthomatous diseases. For this patient, methotrexate was beneficial.

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Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate

Cited by 21 publications

References 9 publications

Multicentric reticulohistiocytosis with elevated cytokine serum levels

Multicentric reticulohistiocytosis with elevated cytokine serum levels

La réticulohistiocytose multicentrique : une affection auto-immune systémique ? À propos d’une forme associée à une polyarthrite rhumatoïde érosive et un syndrome de Sjögren systémique

Reticulohistiocytosis: different dermatoscopic faces and a good response to methotrexate treatment

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