2021
DOI: 10.1111/vop.12890
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Treatment with chloroquine is retinotoxic in captive African penguins (Speniscus demersus). Attenuation and recovery of electroretinographic responses

Abstract: Purpose To evaluate the effect of prophylactic anti‐malarial chloroquine treatment, and its cessation, on electroretinographic (ERG) responses of captive African penguins. Methods A brief ERG protocol (“QuickRetCheck”) was recorded under mesopic conditions with manual restraint and no sedation or pupil dilation. Birds were recorded on two separate occasions, first while being treated with a daily chloroquine dose of 10 mg/kg for 12 days (n = 15, treatment group) and second after 4 months without chloroquine tr… Show more

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“…To treat Plasmodium infections in avian species, the application of chloroquine and primaquine or combination therapies are routinely proposed, although reports about liver toxicity and even death as a result of this treatment in birds exist [6,7]. Besides selecting for resistance, these substances can have substantial side effects in humans as well as in other mammals and birds [8][9][10][11], invoking the need for taxon-specific analyses of drug safety [12]. The synergistic combination of atovaquone and proguanil (Malarone ® , GlaxoSmithKline GmbH & Co. KG, München, Germany) has shown efficacy against hepatic and erythrocytic stages of Plasmodium falciparum with only few and mild adverse effects (e.g., vomiting, diarrhoea, and increases in hepatic transaminases) in adults and children [13].…”
Section: Introductionmentioning
confidence: 99%
“…To treat Plasmodium infections in avian species, the application of chloroquine and primaquine or combination therapies are routinely proposed, although reports about liver toxicity and even death as a result of this treatment in birds exist [6,7]. Besides selecting for resistance, these substances can have substantial side effects in humans as well as in other mammals and birds [8][9][10][11], invoking the need for taxon-specific analyses of drug safety [12]. The synergistic combination of atovaquone and proguanil (Malarone ® , GlaxoSmithKline GmbH & Co. KG, München, Germany) has shown efficacy against hepatic and erythrocytic stages of Plasmodium falciparum with only few and mild adverse effects (e.g., vomiting, diarrhoea, and increases in hepatic transaminases) in adults and children [13].…”
Section: Introductionmentioning
confidence: 99%