Treatment With Cinacalcet of Secondary Hyperparathyroidism After Renal Transplantation

Systematic review of surgical and medical treatment for tertiary hyperparathyroidism

“…12 of 18 Carrasco et al 40 Case series 14 6 n.a. 2 13 of 18 Gómez Marqués et al 45 Retrospective cohort 48 12 13 4 7 of 9 † López et al 48 Case series 29 Range 3-29 27 1 14 of 18 Toro Prieto et al 49 Case series 27 6 n.a. n.a.…”

“…Eleven studies, including 297 patients, described the outcome 'achieving normocalcaemia'. Of these patients, 240 (80⋅8 per cent) achieved normocalcaemia, with individual studies reporting rates ranging from 28 per cent (10 of 36) to 100 per cent 22,36,38,42,45,48,50,51,54,55,57 . Overall, of 578 patients treated with cinacalcet, 37 (6⋅4 per cent) discontinued treatment due to persisting hypercalcaemia or side-effects such as hypocalcaemia, gastrointestinal complaints or paraesthesia.…”

Cinacalcet for hypercalcaemic secondary hyperparathyroidism after renal transplantation: a multicentre, retrospective, 3‐year study

“…Pharmacokinetic and pharmacodynamic studies in patients with SHPT after renal transplantation have shown that daily administration of cinacalcet leads to a sustained reduction of calcium levels over 24 hours . In addition, iPTH levels show a transient reduction between 1–6 h. Cinacalcet also increases serum phosphorus levels …”

“…The effect of cinacalcet in patients with persistent SHPT after renal transplantation has been described in several prospective and retrospective studies (Table ). The results of these studies, with a limited number of patients, were consistent, supporting the effectiveness of cinacalcet in reducing PTH and serum calcium levels in this population .…”

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“…However, its use in kidney transplant recipients remains off-label. Several prospective [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and retrospective [31][32][33][34][35][36][37][38][39][40][41] observational cohort studies have examined the potential effects of cinacalcet in kidney transplant recipients. Most of these studies have included small cohorts with short follow-up periods, whereas only 4 studies have reported follow-up of greater than 3 years.…”