Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model of early obesity

Neto, Jessika Geisebel Oliveira; Boechat, Silvia Karl; Romão, Juliana Santos; Pazos‐Moura, Carmen C.; Oliveira, Karen Jesus

doi:10.1016/j.jnutbio.2019.108321

Cited by 37 publications

(30 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These changes are too small to be clinically relevant. Animal studies have demonstrated that extracts of cinnamon elicit thermogenesis responses [139], reduced visceral adiposity, attenuated hyperphagia and normalized energy efficiency [140] and attenuated obesity through the modulation of genes implicated in the lipid metabolism pathways [141]. Currently, chronic studies conducted with the cinnamon amount usually consumed in an everyday diet are lacking.…”

Section: Cinnamon Available Evidencementioning

confidence: 99%

“…In rats, cinnamon-linked increased rate of cold adaptive thermogenesis was due to the elevation in norepinephrine, blood levels of free fatty acid levels and increased expression of UCP1 in BAT [142]. Experimental studies have reported the ability of cinnamaldehyde in activating phospho-AMPK in adipose tissue [140], enhancing thermogenic and metabolic responses in human subcutaneous fat cells through a cAMP dependent protein kinase/p38 mitogen-activated protein kinase (p38 MAPK)-dependent pathway (involved in the transcription of thermogenic genes) [143] and inducing browning in mice subcutaneous adipocytes by increased expressions of UCP1 and other brown adipocyte markers and involvement of the β3-adrenoreceptor activity [144]. Finally, cinnamaldehyde has been shown to activate the transient receptor potential ankyrin 1 (TRPA1), an ion channel located at the cellular surface, acting as a mechanical and chemical stress sensor, which is involved in adrenalin secretion [145].…”

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

See 1 more Smart Citation

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

View full text Add to dashboard Cite

The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

show abstract

Section: Cinnamon Available Evidencementioning

confidence: 99%

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…also provide evidence that a single dose of cinnamaldehyde (70mg/200ml; 300ppm) significantly increases the energy expenditure by a magnitude of 3.6 kcal over the period of experiment as compared to the placebo group (Michlig et al 2016). Recent evidences also suggested the possible mechanism for the anti-obesity effects of cinnamaldehyde (Camacho et al, 2015;Neto, Boechat et al, 2020). Subcutaneous fat depots contain thermogenic adipocytes which play an important role in thermoregulation and metabolic health during cold exposure.…”

Section: Trpa1 In Bat Thermogenesis and Modulationmentioning

confidence: 99%

TRPA1 in obesity and insulin resistance

Mahajan

Khare

Kondepudi

et al. 2020

Preprint

View full text Add to dashboard Cite

Transient receptor potential ankyrin 1 (TRPA1) channel is a calcium permeable, non-selective cation channel, expressed in the sensory neurons and non-neuronal cells of different tissues. Initially studied for its role in pain and inflammation, TRPA1 has now functionally involved in multiple other physiological functions. TRPA1 channel has been extensively studied for modulation by pungent compounds present in the spices and herbs. In the last decade, the role of TRPA1 agonism in body weight reduction, secretion of hunger and satiety hormones, insulin secretion and thermogenesis, has unveiled the potential of the TRPA1 channel to be used as a preventive target to tackle obesity and associated comorbidities including insulin resistance in type 2 diabetes. In this review, we summarized the recent findings of TRPA1 based dietary/non-dietary modulation for its role in obesity prevention and therapeutics.

show abstract

“…Cinnamaldehyde (found in cinnamon) reported reducing the ER stress in the rat obesity animal model (Neto et al, 2020). The anticancer, oxidative and antioxidative properties of cinnamaldehyde are responsible for its potential to be used against breast cancer, prostate cancer, colon cancer, leukemia, HCC and oral cancers (Hong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Natural products may interfere with SARS-CoV-2 attachment to the host cell

Elfiky

2020

Journal of Biomolecular Structure and Dynamics

162

140

View full text Add to dashboard Cite

SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality) pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be recognized by the viral spike protein, among them is the cell-surface Heat Shock Protein A5 (HSPA5), also termed GRP78 or BiP. Upon viral infection, HSPA5 is upregulated, then translocating to the cell membrane where it is subjected to be recognized by the SARS-CoV-2 spike. In this study, some natural product compounds are tested against the HSPA5 substrate-binding domain b (SBDb), which reported to be the recognition site for the SARS-CoV-2 spike. Molecular docking and molecular dynamics simulations are used to test some natural compounds binding to HSPA5 SBDb. The results show high to a moderate binding affinity for the phytoestrogens (Diadiazin, Genistein, Formontein, and Biochanin A), chlorogenic acid, linolenic acid, palmitic acid, caffeic acid, caffeic acid phenethyl ester, hydroxytyrosol, cis-p-Coumaric acid, cinnamaldehyde, thymoquinone, and some physiological hormones such as estrogens, progesterone, testosterone, and cholesterol to the HSPA5 SBDb. Based on its binding affinities, the phytoestrogens and estrogens are the best in binding HSPA5, hence may interfere with SARS-CoV-2 attachment to the stressed cells. These compounds can be successful as anti-COVID-19 agents for people with a high risk of cell stress like elders, cancer patients, and front-line medical staff. GRAPHICAL ABSTRACT ARTICLE HISTORY

show abstract

Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model of early obesity

Cited by 37 publications

References 57 publications

A Critical Review on the Role of Food and Nutrition in the Energy Balance

A Critical Review on the Role of Food and Nutrition in the Energy Balance

TRPA1 in obesity and insulin resistance

Natural products may interfere with SARS-CoV-2 attachment to the host cell

Contact Info

Product

Resources

About