Treatment with Ebastine Changes Expression of Histamine H1 and H2 Receptor mRNA on Peripheral Blood Mononuclear Cells

Histamine Type 2 Receptor Expression on Peripheral Blood Regulatory Lymphocytes in Patients with Allergic Rhinitis Treated with Specific Immunotherapy

“…It is not known how the activation affects the expression of H2R on Treg cells. Because concanavalin A and IL-2 induce a significant increase of H2R expression in suppressor T CD8+CD25+ 24 and natural allergen stimulation increased significantly both mRNA and phonotypical expression for this receptor in effector Th2 lymphocytes of AR patients, 21,23 it is plausible that the high number of H2R in Treg cells reflects their activation state. Thus, it is possible that Treg cells are continuously activated out of the pollen season and the natural pollen exposure escalates Treg cell activation reflected here by a higher number of H2R within this cell subset.…”

“…4,5,21 The exclusion of H 1 signal transduction in effector T cells favors H2R signaling, which is predominantly associ-ated with Th2 suppression and further inhibition of allergic inflammation. 1,6 H2R may represent an essential receptor that participates in peripheral tolerance or active suppression of inflammatory/immune responses 1,6,22,23 ; however, its role in the biology of Treg cells is far from being understood.…”