Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell

Roy, Subhas Chandra; Metya, Satyajit Kumar; Sannigrahi, Santanu; Rahaman, Noorjaman; Ahmed, Faiqa

doi:10.1007/s12020-012-9868-8

Cited by 120 publications

(94 citation statements)

References 24 publications

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“…In rats induced with diabetes, FA significantly improved blood glucose levels and oxidative status in the pancreatic tissues [82], to a similar extent as other oral anti-diabetic drugs such as metformin and thiozolidinediones (TDZs) [83]. In leptin deficient db/ db mice, FA increased plasma insulin, lowered blood glucose, increased hepatic glycogen synthesis and the upregulated the activity of the glucoceogenesis gene glucokinase [84].…”

Section: Ferulic Acidmentioning

confidence: 73%

“…In various diabetes mouse models, FA works via several mechanisms to reduce blood glucose and increase plasma insulin levels [82]. In rats induced with diabetes, FA significantly improved blood glucose levels and oxidative status in the pancreatic tissues [82], to a similar extent as other oral anti-diabetic drugs such as metformin and thiozolidinediones (TDZs) [83].…”

Section: Ferulic Acidmentioning

confidence: 99%

“…The main targets of FA in preventing oxidative damage include superoxide dismutase (SOD) and catalase (CAT); two enzymes critical to detoxify superoxide anions. In streptozotocin-induced diabetic rats, FA restored SOD and CAT levels in the myocardium and pancreatic tissue [82,87] while simultaneously reducing inflammatory markers and apoptosis in pancreatic β-cells [82]. Interestingly, FA in combination with fish oil was shown to reduce several oxidative markers, improve cognitive state and improve levels of dopamine [88] and other neurotransmitters in a 3-nitropropionic acid model of neurological damage [89].…”

Section: Ferulic Acidmentioning

confidence: 99%

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The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

Lomis¹

2015

J Diabetes Metab

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The gut microflora is a community of trillions of bacterial cells synergistically inhabiting the human gastrointestinal tract. These microbes contact everything that is consumed and release regulatory factors that affect host energy homeostasis, lipid and carbohydrate metabolism, activation of immune cells, oxidative state, epithelial cell wall integrity and even neurological signals. The gut microflora is essentially an independent organ supporting human health where imbalances in the gut community populations (dysbiosis) manifest in disease. Diabetes and neurodegenerative disorders such as Alzheimer's and Parkinson's disease share a similar molecular pathology rooted in gut microflora activity. Both of these conditions are associated with a dysbiosis characterized by low species diversity, a higher proportion of pathobionts at the expense of symbionts, an abundance of proinflammatory microbes and fewer butyrate-producing strains. Many of these factors can be ameliorated with Lactobacillus spp. and Bifidobacterium spp. probiotic treatment aimed to reestablish healthy gut microflora diversity. Indeed, certain commensal and pathogenic strains promote chronic low-grade inflammation that stresses cellular infrastructure eventually leading to apoptosis in both the pancreas and the brain. Also, lack of some beneficial fermentation products such as butyrate and ferulic acid initiates a cascade of events disrupting metabolic homeostasis. Finally, signaling initiated by the microflora and its metabolites has been shown to disrupt the delicate intracellular balance of PI3K/Akt/mTOR signaling, which fundamentally regulates events leading up to diabetes and neurodegenerative disease pathogenesis. The following review investigates the relationship between the manifestation and molecular signaling of diabetes and neurodegenerative disorders and how the balance of gut microflora populations is critical to both prevent and possibly treat these diseases.

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Section: Ferulic Acidmentioning

confidence: 73%

Section: Ferulic Acidmentioning

confidence: 99%

Section: Ferulic Acidmentioning

confidence: 99%

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The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

Lomis¹

2015

J Diabetes Metab

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“…In this respect YG was most potent drug amongst the six formulations studied. Especially antioxidant properties of FA have been studied in cardioprotection 26 and the role of PCA, VA in reducing lipid peroxidation 27 has been well established. Production of NO and PGE2 were suppressed by CGA via down-regulation of iNOS and COX-2 28 and have shown antiosteoarthritis properties.…”

Section: Phenolic Acid Analysis By Hplcmentioning

confidence: 99%

HPLC Analysis of Phenolic Acids and Antioxidant Activity of Some Classical Ayurvedic Guggulu Formulations

Hazra¹,

Sur²,

Chakraborty³

et al. 2018

Int. J. Res. Ayurveda Pharm.

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Classical guggulu formulations have been used as mainstay therapeutics in chronic inflammatory diseases in Ayurvedic system of medicine since centuries. The present study included six guggulu formulations such as Kaishora guggulu, Kanchanara guggulu, Yogaraj guggulu, Punrnava guggulu, Amritadi guggulu and Trayodasanga guggulu.Phenolic compounds play a vital role as evident from phenolic and flavonoid content in guggulu drugs as well as antioxidant activity assayed by DPPH radical scavenging activity and FRAP antioxidant power. Yograj guggulu was found to have strong reducing ability (1156.76 µM Fe(II)/mg) among six drugs chosen in this investigation and Amritadi guggulu has revealed powerful scavenger of DPPH radicals (IC50:1.05 mg/ml). Phenolic acid composition for each guggulu drug was analyzed and twelve phenolic acid compounds were identified and estimated by HPLC. Gallic acid (8.29-49.28 mg/g) was found in high concentration and ellagic acid (0.69-6.02 mg/g) was found to the next in all formulations. Other phenolic acid components estimated were protocatechuic acid, p-hydroxybenzoic acid, gentisic acid, chlorogenic acid, vanillic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, sinapic acid in all guggulu formulations. A synergistic activity towards therapeutic efficacy was proposed on the basis of phenolic acid composition in each guggulu formulation.

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“…T2DM is associated with reduced pancreatic b-cells, mainly because of cell apoptosis, an effect of high blood sugar, high cholesterol, and insulin resistance (93). With a reduction in pancreatic b-cells and progression of insulin resistance, the relative lack of insulin production thus results in diabetes.…”

Section: Types Of Diabetesmentioning

confidence: 99%

Applicability of Adipose-Derived Stem Cells in Type 1 Diabetes Mellitus

Lin

Chan

et al. 2015

Cell Transplant

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Type 1 diabetes mellitus (T1DM) is a form of early onset diabetes mellitus characterized by the autoimmune destruction of insulin-producing cells (IPCs), resulting in hyperglycemia and abnormal glucose metabolism. There are currently no treatments available capable of completely curing the symptoms associated with the loss or functional defects of IPCs. Nonetheless, stem cell therapy has demonstrated considerable promise in the replacement of IPCs with immunomodulatory functions to overcome the defects caused by T1DM. Adipose-derived stem cells (ADSCs) are particularly suitable for use in cell transplantation therapy, especially when seeking to avoid the ethical issues and tumorigenic complications commonly associated with embryos or induced pluripotent stem cells. Cell-based treatments have demonstrated therapeutic advantages and clinical applicability of ADSCs in T1DM, ensuring their suitability for transplantation therapy. This manuscript focuses on the benefits and possible mechanisms in a T1DM-relevant model and displays positive results from finished or ongoing human clinical trials. We also discuss and hypothesize potential methods to further enhance the therapeutic efficacy of these efforts, such as a humanized rodent model and gene therapies for IPC clusters, to meet the clinical applicability of the standard.

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Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell

Cited by 120 publications

References 24 publications

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

HPLC Analysis of Phenolic Acids and Antioxidant Activity of Some Classical Ayurvedic Guggulu Formulations

Applicability of Adipose-Derived Stem Cells in Type 1 Diabetes Mellitus

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