Treatment with GH and IGF-1 in Critical Illness

Chung, Teng Teng; Hinds, C. J.

doi:10.1016/j.ccc.2005.09.003

Cited by 33 publications

(14 citation statements)

References 69 publications

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“…As the need for urgent surgical intervention for raised intracranial pressure takes priority at diagnosis, there is less opportunity to make a diagnosis of growth hormone deficiency via provocative testing, in which case the measurement of a baseline insulin-like growth factor-1 level can be helpful. If the patient is receiving growth hormone therapy, this should be stopped prior to surgery, as is recommended in any patient with an acute critical illness [11]. …”

Section: Pre-operative Overviewmentioning

confidence: 99%

Management of Electrolyte and Fluid Disorders after Brain Surgery for Pituitary/Suprasellar Tumours

Albanese

2015

Horm Res Paediatr

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Disturbances in salt and water balances are relatively common in children after brain surgeries for suprasellar and pituitary tumours, presenting diagnostic and therapeutic challenges. Although hypernatraemia associated with central diabetes insipidus is commonly encountered, it is hyponatraemia (HN) that poses more of a diagnostic dilemma. The main differential diagnoses causing HN are the syndrome of inappropriate antidiuretic hormone secretion, marked by inappropriate retention of water, and cerebral salt wasting, characterized by polyuria and natriuresis. Diagnosis and management can be even more difficult when these conditions precede or coexist with each other. These diagnostic and therapeutic dilemmas are discussed in detail in this review.

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Section: Pre-operative Overviewmentioning

confidence: 99%

Management of Electrolyte and Fluid Disorders after Brain Surgery for Pituitary/Suprasellar Tumours

Albanese

2015

Horm Res Paediatr

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“…However, GH-treatment perioperatively is unsuitable since GH-treated critically ill patients, in two large randomized studies, had doubled mortality compared to their controls [39]. The mechanism behind this unexpected dramatic adverse effect by rhGH-treatment is still unknown but supposed to be caused by GHs immune modulating effect or GHs secondary negative effect on glucose homeostasis [40]. IGF-1 is not suspected and in a review IGF-1 was demonstrated to be safe [41].…”

Section: Discussionmentioning

confidence: 99%

Untitled

et al. 2007

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Background: Surgery, commonly performed after an overnight fast, causes a postoperative decline in the anabolic and glucose lowering insulin-like growth factor-1 (IGF-1). Clinical fasting studies have exhibited a positive correlation between IGF-1 and nitrogen balance during different conditions. A perioperative amino acid infusion changes nitrogen balance and might thereby influence serum IGF-1. We hypothesized that amino acid infusion would enhance IGF-1 and thereby might influence glucose homeostasis after surgery. In this study we examined two different regimes of perioperative amino acids infusion.

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“…Serum GH levels start to increase in the early hours after the onset of critical illness. Both frequency and amplitude of GH pulses are increased, associated with loss of the typical depressions during interpulse periods, which leads to elevated serum concentrations (86). In addition, the hepatic GH receptor function is suppressed.…”

Section: Growth Hormone In Critically Ill Patientsmentioning

confidence: 99%