Treatment with Interferon-α-2b in Children with Life-Threatening Hemangiomas

Jiménez‐Hernández, Elva; Dueñas‐González, María Teresa; Quintero-Curiel, Jose Luis; Velásquez‐Ortega, José; MAGAÑA-PÉREZ, JOSÉ A; Berges‐García, Adolfina; Arellano‐Galindo, José

doi:10.1097/00042728-200805000-00007

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…This also requires regular follow-ups with a pediatrician. The reported adverse side effects include flu-like symptoms, transient neutropenia, liver toxicity, and neurotoxicity [54]. In cases of severe vision-threatening lesions that are unresponsive, treatment with chemotherapy such as vincristine and alkylating agents like cyclophosphamide under the care of oncologists may be promising.…”

Section: Medical Management and Expected Outcomesmentioning

confidence: 99%

Periocular Hemangioma: Clinicopathological Aspects

M. Alkatan,

R. Fatani,

A. Helmi

et al. 2024

Common Childhood Diseases - Diagnosis, Prevention and Management [Working Title]

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Hemangiomas are pathologically considered to be developmental hamartomatous lesions. In the periocular region, capillary hemangioma is commonly encountered in infants and children, and it is of particular importance because of its critical location if involving the eyelid with obstruction of the visual axis. In this chapter, we aim to briefly discuss the pathogenesis and etiology of such lesions, describe the histopathological features, and the diagnostic immunohistochemical stains used, with differentiating features between infantile hemangioma and capillary hemangioma in adults. In the periocular region, the clinical appearance and manifestations depend on three primary locations of the hemangioma: the superficial, subcutaneous, and deep orbital hemangiomas. Treatment options are similar to hemangioma elsewhere, however, as mentioned above, early treatment may be advocated to avoid developing amblyopia (lazy eye) because of visual deprivation or obstruction. The most used therapy in the periocular region is beta-blockers, either orally or locally. Intralesional steroids and sclerosing agents may also be used. Surgical intervention is reserved for deep orbital-selected lesions.

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Section: Medical Management and Expected Outcomesmentioning

confidence: 99%

Periocular Hemangioma: Clinicopathological Aspects

M. Alkatan,

R. Fatani,

A. Helmi

et al. 2024

Common Childhood Diseases - Diagnosis, Prevention and Management [Working Title]

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“…However, the prolonged treatment of numerous months, leading to significant adverse effects such as neutropenia, hepatotoxicity, and permanent spastic diplegia, discouraged the usage of this drug in management. [36] Other drugs such as imiquimod, vincristine, and bleomycin A5 were now longer used often.…”

Section: Medical Managementmentioning

confidence: 99%

Capillary hemangioma – A review

Wadhwani¹,

Singh²

2020

cleverjournal

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Capillary hemangioma (CH) also known as strawberry nevi can present as a small red raised isolated lesion. Imaging techniques such as ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) may be used to differentiate CH from other vascular tumors, to identify the extent of tumor. Management should be customized according to the age of the child, extent and size of the tumor(s), growth rate, depth (superficial, deep or mixed).

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Treatment with Interferon-α-2b in Children with Life-Threatening Hemangiomas

Cited by 2 publications

References 30 publications

Periocular Hemangioma: Clinicopathological Aspects

Periocular Hemangioma: Clinicopathological Aspects

Capillary hemangioma – A review

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