Treatment with low-dose aspirin increased the level LIF and integrin β3 expression in mice during the implantation window

Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome

“…These data are in keeping with previous reports showing that letrozole is associated with a thicker endometrium leading to improved vascularization, as shown with Doppler studies (4,7). More recent studies have shown that increases in blood flow to the endometrium help with implantation, thus reinforcing the need for neovascularization (27).…”

Effects of icariin on the expression of ER, VEGF, and KDR in the endometrial cells of thin endometrium

“…The treatments mainly focus on medications that target the primary disease by regulating endocrine secretion and improving microcirculation (Gargett and Masuda, 2010;Glujovsky et al, 2010;Zhao et al, 2010;Bodombossou-Djobo et al, 2011;Gleicher et al, 2011;Hu and Yuan, 2011;Nagori et al, 2011;Revel, 2012). The treatment efficacy of icariin on thin endometrium has been approved based on the results from clinical trials.…”

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

“…Whereas some studies could not demonstrate any benefit in IVF outcome [131,132], others reported an increase in pregnancy rate, sometimes with even statistically significant impact [133,134,135]. The aspirin influence on IVF outcome and in particular, the action connected with inherited thrombophilia, again is not eluciadated, although Zhao et al [81] found increased alphaV/beta3 integrin expression in the uterine endometrium in aspirin presence. Speculating from the above finding the polymorphism A1/ A2 in beta3 subunits of integrin alphaV/beta3 could be related with impared embryo adhesion but this should be confirmed in future studies.…”

“…Independent significance of thrombophilia is hard to evaluate because of assembled information for many other recently discussed IVF failure risk factors which are outside the thrombophilic group factors. Apoptosis and cell arrest tumor suppressor factor p53 [79], inducing angiogenesis vascular endothelial growth factor (VEGF) [80] or Leukemia inhibitory factor (LIF) [81] are a part of these agents. These factors should be considered in the impact of thrombophilic factors discussion because the recent approach in consultation after IVF failure investigations is to identify the combination of defects [80] instead of one factor that will lead to implantation failure.…”