Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells

Alaca, Nuray; Özbeyli, Dilek; Uslu, Serap; Şahin, Hasan; Yiğittürk, Gürkan; Kurtel, Hızır; Öktem, Gülperi; Yeğen, Berrak Ç.

doi:10.5152/tjg.2017.16742

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…MDA is a tissue injury index produced in BDLinduced rats due to the toxicity caused by ROS (Catalá, 2012). In a study by Alaca et al (2017), MDA levels in the BDL group were higher than the control group (Alaca et al, 2017). Zhao et al (2017) found that the levels of MDA augmented after surgery in BDL rats (Zhao et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Chronic liver disease is a major cause of global health problems, causing around 800,000 deaths worldwide annually (Saleh et al, 2015). Cholestasis is a common liver disease (Alaca et al, 2017). Any condition in which the flow of bile from the liver is slowed or blocked is called cholestasis, which results in abnormal accumulation of bile acids.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

2020

THE JAPS

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

2020

THE JAPS

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“…Silymarin exerts anti‐inflammatory actions and attenuates autoimmune and immune‐mediated liver diseases, possibly via suppression of oxidative and nitrosative immunotoxicity and T‐lymphocyte function (Esmaeil, Anaraki, Gharagozloo, & Moayedi, ; Milić, Milosević, Suvajdzić, Zarkov, & Abenavoli, ). Anti‐inflammatory activities of silymarin or MT extracts have been observed in a number of rat/mouse models of liver diseases, including cholestatic liver injury (Alaca et al, ), CCl4‐induced hepatoxicity (Clichici et al, ), restraint stress‐induced acute liver (Kim et al, ), the stelic animal model of steatohepatitis (Pais & D'Amato, ), zidovudine/isoniazid‐induced liver toxicity (Raghu & Karthikeyan, ), and, finally, a model of steatohepatitis induced by a methionine and choline deficient diet (Aghazadeh, Amini, Yazdanparast, & Ghaffari, ).…”

Section: Experimental Pharmacologymentioning

confidence: 99%

Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

Abenavoli

Izzo

Milić

et al. 2018

Phytotherapy Research

335

201

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Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic herb with a 2,000-year history of use. MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, the pharmacologically relevant actions for liver diseases (e.g., anti-inflammatory, immunomodulating, antifibrotic, antioxidant, and liver-regenerating properties) as well as the clinical potential in patients with alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, drug-induced liver injury, and mushroom poisoning. Overall, literature data suggest that, despite encouraging preclinical data, further well-designed randomized clinical trials are needed to fully substantiate the real value of MT preparations in liver diseases.

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“…34 The hepatoprotective effects of UDCA can be in part explained by its modulating effects on inflammatory processes. 35,36 Furthermore, UDCA treatment counteracted with both oxidative and nitrosative stresses in patients with PBC. 37 UDCA treatment also activated anti-apoptotic pathways via upregulating Bcl-2 and Bax in hepatocytes of mouse model of drug-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Ursodeoxycholic Acid on Valproic Acid Induced Hepatotoxicity in Epileptic Children with Recurrent Seizure; A Double-Blinded Randomized Clinical Trial

et al. 2020

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Background : There are controversies regarding the protective role of ursodeoxycholic acid (UDCA) against valproic acid (VPA)-induced hepatotoxicity in children. In the present clinical trial, we assessed the potential role of UDCA in preventing VPA-induced fluctuations of hepatic enzymes in epileptic children with recurrent seizures. Methods: Two-hundred children with epileptic seizures were randomly allocated into either intervention (VPA+UDCA) or control (VPA+ placebo) group. Fluctuations of liver enzymes were recorded at baseline, as well as 48 hours, 1 month, and 3 months following the interventions. Results: The mean age of the patients was 7.33±2.96 years (the range of 4-16). Males and females constituted 43 (43%) and 57 (57%) subjects in each group respectively. There were no significant differences in the baseline levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) between the intervention and control groups. At 48 hours post-intervention, AST and ALT increased 1.7% and 11.05% (23.18±7.91 and 30.75±4.20 IU/l) in the intervention group and 21.3% and 35% (28.46±3.71 and 35.62±7.72 IU/l) in the control group respectively (P<0.0001). Both AST (P<0.001) and ALT (P=0.03) levels were significantly lower in the intervention than placebo group at 1-month post-intervention. At 3-month post-intervention; however, while AST level still was significantly higher in the control (29.87±5.41 IU/l) than intervention (21.63±6.87 IU/l, P<0.0001), ALT level was not significantly different between the two groups (32.72±5.59 IU/l and 32.01±7.89 IU/l respectively, P=0.5). Conclusion: UDCA can be an effective drug to manage VPA-induced fluctuations of hepatic enzymes in children with recurrent epileptic seizures.

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Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells

Cited by 20 publications

References 23 publications

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

Protective Effects of Ursodeoxycholic Acid on Valproic Acid Induced Hepatotoxicity in Epileptic Children with Recurrent Seizure; A Double-Blinded Randomized Clinical Trial

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