Treatment with platelet-rich plasma attenuates proprioceptor abnormalities in a rat model of postpartum stress urinary incontinence

Liu, Jiaojiao; Liu, Zhaoxue; Tang, Yuan; Muñoz, Alvaro; Zhang, Yingchun; Li, Xuhong

doi:10.1007/s00192-022-05112-w

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…They then compared them with 10 control rats with postpartum SUI who received no intervention. Significantly improved bladder leak point pressure (BLPP) (27.05 ± 6.52 vs. 19.16 ± 2.26, P < 0.01 ) and abdominal leaking-urine point pressure (ALPP) (35.40 ± 5.22 vs. 25.08 ± 2.05, P < 0.01 ) were observed 28 days posttreatment [14 ▪ ]. Despite the fact that both groups presented significant morphological variations in muscle spindles compared to rats without SUI, the PRP group had lower variations than the control one [14 ▪ ].…”

Section: Historical Data and Current Landscapementioning

confidence: 98%

“…Additionally, Nikolopoulos et al reported improvement of SUI 2 months after PRP injection in an animal experimental model of transected pubourethral ligament [13]. More recently, Liu et al evaluated the effect of pelvic floor muscles PRP injections in a rat model of postpartum SUI with vaginal dilation ( n = 10 rats)[14 ▪ ]. They then compared them with 10 control rats with postpartum SUI who received no intervention.…”

Section: Historical Data and Current Landscapementioning

confidence: 99%

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Platelet rich plasma for the management of urogynecological disorders: the current evidence

Prodromidou

Grigoriadis

Athanasiou

2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewOur objective is to review the currently available literature on the use of platelet-rich plasma (PRP) in patients with pelvic floor disorders and to critically appraise the latest evidence on the safety and efficacy of the PRP application.Recent findingsThe evidence on the use of PRP for the treatment of stress urinary incontinence (SUI) appears promising, although limited to case series, case reports and animal studies. PRP has also been proposed to enhance the surgical outcomes of pelvic organ prolapse (POP) by native tissue repair with promising success rates. The application of PRP in other PFDs including vaginal fistulas, genitourinary syndrome of menopause (GSM), mesh exposure and lichen sclerosus has been also associated with beneficial outcomes and a favorable safety profile.SummaryThe currently available literature indicates that PRP could have a beneficial effect as a single or adjuvant treatment in patients with SUI, POP, GSM, vaginal fistula and genital lichen sclerosus with minimal adverse events. However, valid evidence is still lacking and further well-designed studies are warranted in the field to confirm the validity of the so far reported outcomes.

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Section: Historical Data and Current Landscapementioning

confidence: 98%

Section: Historical Data and Current Landscapementioning

confidence: 99%

Platelet rich plasma for the management of urogynecological disorders: the current evidence

Prodromidou

Grigoriadis

Athanasiou

2022

Current Opinion in Obstetrics &Amp; Gynecology

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“…Previous studies remarked on the importance of proprioception in motor control and its alterations in women with SUI (6). Also, an animal study showed atypical expression of pelvic proprioceptors in rats with SUI, affecting PFM contractibility (16).…”

Section: Introductionmentioning

confidence: 99%

Better Sense of Force Accuracy in Women with Stress Urinary Incontinence Compared with Women Without Stress Urinary Incontinence: A Surprising Result in a Case-Control Study

Kharaji¹,

Nikjooy²,

Amiri³

et al. 2022

Middle East J Rehabil Health Stud

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Background: It has been demonstrated that pelvic floor muscles (PFMs) are involved in the pathophysiology of stress urinary incontinence (SUI). Sense of force, an aspect of proprioception, has never been evaluated in PFMs. Objectives: This study aimed to assess the proprioception of PFMs by evaluating the accuracy of force sense in adult women with SUI compared to those with continence. A further aim was to study the accuracy of force sense between various lengths and tensions of PFMs. Methods: Twenty-three women with SUI and 18 women without it were recruited in six trials with four different test conditions: 5 mm/40% (speculum opening/maximum voluntary contraction (MVC) percentage to produce), 5 mm/70%, 10 mm/40%, and 10 mm/70%. All participants were asked to reproduce the target force based on their own perceptions. The dynamometer was used to evaluate the sense of force. Results: The accuracy of force sense differed between women with SUI and those without it. In all test conditions, women with SUI had higher force reproduction accuracy. The highest amount of error was recorded at 10 mm and 40% MVC for either group. Conclusions: Women with SUI were more accurate in reproducing the target force than those with continence. Higher force sense accuracy may result from more attention to the pelvic floor area and a lack of automaticity of movements in women with SUI. Therefore, developing therapeutic management focusing on restoring automaticity seems advisable.

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Injection therapy for urinary incontinence: An innovation under the minimally invasive pinhole

Lin,

Sun

2024

Neurourology and Urodynamics

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Treatment with platelet-rich plasma attenuates proprioceptor abnormalities in a rat model of postpartum stress urinary incontinence

Cited by 5 publications

References 28 publications

Platelet rich plasma for the management of urogynecological disorders: the current evidence

Platelet rich plasma for the management of urogynecological disorders: the current evidence

Better Sense of Force Accuracy in Women with Stress Urinary Incontinence Compared with Women Without Stress Urinary Incontinence: A Surprising Result in a Case-Control Study

Injection therapy for urinary incontinence: An innovation under the minimally invasive pinhole

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