Treatment with prostaglandin F2α and an intravaginal progesterone insert promotes follicular maturity in advance of gonadotropin-releasing hormone among postpartum beef cows

Bonacker, R.C.; Stoecklein, Katy S; Locke, J.W.C.; Ketchum, Jaclyn N; Knickmeyer, E; Spinka, Christine; Poock, S.E.; Thomas, Jordan M.

doi:10.1016/j.theriogenology.2020.08.018

Cited by 21 publications

(32 citation statements)

References 43 publications

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“…Although these follicles will appear physiologically mature, the oocyte is functionally compromised due to intrafollicular changes resulting in premature resumption of meiosis [16]. In the present experiment, the increase observed in the proportion of cows that expressed estrus prior to FTAI following 7 & 7 Synch is attributed to the greater degree of uniformity previously observed among cows using this treatment schedule [8]. By improving follicular maturity in advance of GnRH administration, variation among cows is reduced later in the protocol.…”

Section: Pregnancy Ratementioning

confidence: 45%

“…The single-step approach of combining a progestin and PG at the beginning of 7 & 7 Synch induces persistent follicle formation among a large proportion of cows in advance of GnRH administration[8]. However, the intentional formation of persistent follicles is advantageous in this context as a means to enhance follicular maturity on Day -10 [8], thereby improving likelihood of ovulatory response to GnRH administration and subsequent emergence of a new synchronized follicular wave.…”

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confidence: 99%

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Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Andersen

Bonacker

Smith

et al. 2020

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An experiment was designed to compare the recently developed 7 & 7 Synch and the 7-day CO-Synch + CIDR protocols for synchronization of estrus among beef cows prior to fixed-time artificial insemination (FTAI) with conventional or sex-sorted semen. Bos taurus cows (n = 1538) were blocked based on age and days postpartum (DPP) and randomly assigned to protocol and semen type. Cows treated with the 7-day CO-Synch + CIDR protocol (n = 769) received administration of gonadotropin-releasing hormone (GnRH; 100 μg gonadorelin) and insertion of a 1.38 g intravaginal progesterone releasing insert (CIDR) on Day -10, and administration of prostaglandin F2α (PG; 500 μg cloprostenol) coincident with CIDR removal on Day -3. Cows treated with 7 & 7 Synch (n = 769) received PG and insertion of CIDR on Day -17, GnRH on Day -10, and PG coincident with CIDR removal on Day -3. Estrus detection aids (Estrotect™) were applied to all cows on Day -3, and activation status was recorded at FTAI. Cows received FTAI 66 h after CIDR removal with either conventional (20 × 106 cells per unit) or sex-sorted (4 × 106 cells per unit; SexedULTRA 4M™) semen. A greater proportion of cows expressed estrus (P = 0.01) prior to FTAI following 7 & 7 Synch (82%; 629/769) compared with the 7-day CO-Synch + CIDR (64%; 492/769). Estrus expression was also affected by protocol × DPP (P = 0.0004), with 7 & 7 Synch resulting in a greater increase in the proportion of cows expressing estrus prior to FTAI among cows with greater DPP. Across protocols, body condition score (BCS) affected (P = 0.05) estrus expression, with greater proportion of cows expressing estrus prior to FTAI at greater BCS. Sex-sorted semen resulted in reduced (P < 0.0001) pregnancy rates to FTAI. Irrespective of semen type, greater (P = 0.001) pregnancy rates to FTAI were obtained among cows treated with 7 & 7 Synch (conventional semen: 72% [280/389]; sex-sorted semen: 52% [199/380]) compared with the 7-day CO-Synch + CIDR (conventional semen: 60% [231/383]; sex-sorted semen: 44% [171/386]). In summary, 7 & 7 Synch resulted in an increased proportion of cows expressing estrus prior to FTAI and an increased pregnancy rate to FTAI with conventional and sexed semen. With these results and ease of application, 7 & 7 Synch offers potential as a platform to improve success with fixed-time AI in beef cows.

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Section: Pregnancy Ratementioning

confidence: 45%

mentioning

confidence: 99%

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Andersen

Bonacker

Smith

et al. 2020

Preprint

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“…Gonadorelin is indicated for increasing the functional capacity and response of the gonadotropes of the anterior pituitary and after removal of a pituitary tumor by increasing residual gonadotropic function of the pituitary. Gonadorelin has agonist action on both gonadotropin-releasing hormone receptor and putative gonadotropin-releasing hormone II receptor [37], thus it might have inhibiting effect on COVID-19 protease as the score of ligand protein interaction with the target is -6.7 (kcal/mol).…”

Section: Other Potential Protease Inhibitorsmentioning

confidence: 99%

Direct acting anti-hepatitis C combinations as potential COVID-19 protease inhibitors

2021

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The coronavirus pandemic could be the most threatening outbreak in the twenty-first century. According to the latest records of world health organization, more than 130 millions have been infected by COVID-19, with more than 2.9 million reported deaths. Yet, there is no magic cure for treatment of COVID-19. The concept of drug repurposing has been introduced as a fast, life-saving approach for drug discovery. Drug repurposing infers investigating already approved drugs for new indications, using the available information about pathophysiology of diseases and pharmacodynamics of drugs. In a recent work, more than 3000 FDA approved drugs were tested using virtual screening as potential antiviral agents for COVID-19. In this work, the top ranked five hits from the previous docking results together with drugs of similar chemical feature and/or mechanistic destinations were further tested using AutoDock Vina. The results showed that anti-HCV combinations could be potential therapeutic regimens for COVID-19 infections.

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“…By administering PG and placing a CIDR in advance of GnRH administration, an increased proportion of cows present with a physiologically mature, LH-responsive follicle at the time of GnRH administration (Bonacker et al, 2020a;French et al, 2013;Small et al, 2009). This approach is of practical significance as a simple, one-step method for presynchronization, and early results with the 7 & 7 Synch protocol that incorporates this presynchronization approach have suggested improved control of the estrous cycle (Bonacker et al, 2020a(Bonacker et al, , 2020b.…”

Section: Discussionmentioning

confidence: 99%

“…Inducing intentional follicular persistent through use of subluteal progesterone is an effective method to enhance follicular maturity. Bonacker et al performed an experiment evaluating treatments to promote follicular maturity in advance of administration of exogenous GnRH administration for increased control of the estrous cycle (Bonacker et al, 2020b). The experiment was designed to evaluate the physiology behind inducing a persistent follicle as a presynchronization strategy.…”

Section: These Presynchronization Treatment Schedules Involve Administering Pg or Pg Andmentioning

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Evaluation of the 7 and 7 synch protocol for control of the estrous cycle among beef cows prior to fixed-time artificial insemination with sex-sorted or conventional semen

Andersen¹

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Experiment 1 was conducted to compare 7 and 7 Synch and the 7-day CO-Synch + controlled internal drug release (CIDR[copyright]) protocols prior to fixed-time artificial insemination (FTAI) of beef cows with conventional or sex-sorted semen. Cows (n = 1,538) were blocked based on age and days postpartum (DPP) and randomly assigned to protocol and semen type. Cows assigned to 7-day CO-Synch + CIDR (n = 769) received administration of gonadotropin-releasing hormone (GnRH) and insertion of an intravaginal progesterone-releasing insert (CIDR) on Day -10, and administration of prostaglandin F2[alpha] (PG) coincident with CIDR removal on Day -3. Cows assigned to 7 and 7 Synch (n = 769) received PG and insertion of CIDR on Day -17, GnRH on Day -10, and PG coincident with CIDR removal on Day -3. Estrus detection aids were applied to all cows. Cows received FTAI 66 h after CIDR removal with conventional (20 x 106 cells per unit) or sex-sorted (4 x 106 cells per unit) semen. Estrus expression was affected by protocol (P = 0.01) by protocol x DPP (P = 0.0004), with 7 and 7 Synch (82 percent; 629/769) resulting in a greater proportion of cows expressing estrus (82 percent [629/769] versus 64 percent [492/769]), especially among cows with greater DPP. Pregnancy rates to FTAI were reduced (P < 0.0001) when using sex-sorted semen but greater among cows treated with 7 and 7 Synch (conventional semen: 72 percent [280/389]; sex-sorted semen: 52 percent [199/380]) compared with 7-day CO-Synch + CIDR (conventional semen: 61 percent [233/383]; sex-sorted semen: 44 percent [171/386]). Experiment 2 was designed to evaluate later timing of fixed-time artificial insemination (FTAI) with sex-sorted semen among postpartum beef cows following the 7 and 7 Synch protocol, with the hypothesis that later timing would result in increased pregnancy rates (P/AI) among cows that expressed estrus prior to FTAI. Beef cows (n=414) were blocked based on age and days postpartum (DPP) and randomly assigned to receive FTAI at 66 or 72 h after administration of prostaglandin F2[alpha] (PG). Estrus was synchrized using the 7 and 7 Synch protocol, which consists of administration of PG (500 [mu]g cloprostenol) and insertion of an intravaginal progesterone-releasing insert (CIDR; 1.38 g progesterone) on Day 0, gonadotropin-releasing hormone (GnRH; 100 [mu]g gonadorelin) on Day 7, and PG coincident with CIDR removal on Day 14. Estrus detection aids (EstrotectTM) were applied to all cows on Day 14, and activation status was recorded at fixed-time artificial insemination (FTAI) on Day 17. All cows that expressed estrus prior to FTAI received sex-sorted semen (4 x 106 cells per unit; SexedULTRA 4MTM). The proportion of cows expressing estrus prior to FTAI did not differ between treatments at this power of test (66 h: 71 percent [146/205]; 72 h: 76 percent [158/209]). Additionally, P/AI of estrous cows inseminated with sex-sorted semen did not differ between treatments (66 h: 45 percent [68/146]; 72 h: 40 percent [63/158]). In conclusion, later timing of FTAI following the 7 and 7 Synch protocol failed to improve P/AI of estrous cows inseminated h sex-sorted semen.

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Treatment with prostaglandin F2α and an intravaginal progesterone insert promotes follicular maturity in advance of gonadotropin-releasing hormone among postpartum beef cows

Cited by 21 publications

References 43 publications

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Direct acting anti-hepatitis C combinations as potential COVID-19 protease inhibitors

Evaluation of the 7 and 7 synch protocol for control of the estrous cycle among beef cows prior to fixed-time artificial insemination with sex-sorted or conventional semen

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Treatment with prostaglandin F2α and an intravaginal progesterone insert promotes follicular maturity in advance of gonadotropin-releasing hormone among postpartum beef cows

Cited by 21 publications

References 43 publications

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Direct acting anti-hepatitis C combinations as potential COVID-19 protease inhibitors

Evaluation of the 7 and 7 synch protocol for control of the estrous cycle among beef cows prior to fixed-time artificial insemination with sex-sorted or conventional semen

Contact Info

Product

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Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen

Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR^®protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen