2018
DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.043
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Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia

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Cited by 28 publications
(23 citation statements)
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“…Stroke is a major cause of age-related morbidity and mortality. Treatment with exogenous UA or more soluble UA analogs can be beneficial in animal stroke models (Dhanesha et al, 2018; Haberman et al, 2007; Romanos et al, 2007; Yu et al, 1998). However, in humans, both positive and negative associations between levels of UA and the outcome of ischemic stroke have been reported.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Stroke is a major cause of age-related morbidity and mortality. Treatment with exogenous UA or more soluble UA analogs can be beneficial in animal stroke models (Dhanesha et al, 2018; Haberman et al, 2007; Romanos et al, 2007; Yu et al, 1998). However, in humans, both positive and negative associations between levels of UA and the outcome of ischemic stroke have been reported.…”
Section: Resultsmentioning
confidence: 99%
“…UA is one of the most abundant antioxidant molecules in humans with a potent ability to scavenge peroxynitrite, nitric oxide, and hydroxyl radicals, thereby preventing protein nitration and lipid peroxidation (Hooper et al, 1997, 1998). Studies in animal models have shown that administration of UA or soluble UA analogs that retain the antioxidant properties of UA protects the brain against ischemic injury (Aliena-Valero et al, 2018; Dhanesha et al, 2018; Haberman et al, 2007; Justicia et al, 2017; Yu et al, 1998), and a UA analog accelerates wound healing (Chigurupati et al, 2010), suggesting that UA can protect cells against injury and enhance repair of damaged tissue. The positive correlation between life span and UA levels among mammalian species suggests a potential role for UA in mitigating the aging process (Cutler, 1984).…”
Section: Introductionmentioning
confidence: 99%
“…[8] In addition, ROS are critical in initiating the post-ischemic inflammatory response which further exacerbates ischemic injury. [10][11][12][13][14][15] However, low molecular weight antioxidants (for instance NXY-059) have historically not translated well in the treatment of stroke patients. [10][11][12][13][14][15] However, low molecular weight antioxidants (for instance NXY-059) have historically not translated well in the treatment of stroke patients.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, ROS are critical in initiating the post‐ischemic inflammatory response which further exacerbates ischemic injury . There is an abundance of experimental and clinical research supporting ROS as a promising therapeutic target for acute ischemic stroke . However, low molecular weight antioxidants (for instance NXY‐059) have historically not translated well in the treatment of stroke patients.…”
Section: Introductionmentioning
confidence: 99%
“…MRI was performed on day-1 post reperfusion as per previously described protocol. 17 Briefly, animals were anesthetized with isoflurane (2.5% induction, 1.2% maintenance) and placed in the bore of the 7.0 Tesla MRI (Agilent Technologies Inc., Santa Clara, CA, USA) with a two-channel receive-only surface coil. Following scout scans to orient the imaging planes; high-resolution images were acquired with a 9-minute T2-weighted 2D fast spinecho pulse sequence oriented coronally.…”
Section: Mri Imaging and Infarct Volume Quantificationmentioning
confidence: 99%