Treatment with Vitamin D3 in Vitamin D Deficient Adolescents: A Pilot Study

Abstract

Multiple epidemiological studies have shown that vitamin D deficiency is highly prevalent amongst adolescents in the USA. However, recommendations regarding the treatment of vitamin D deficiency in healthy adolescents are not well defined. We carried out a prospective pilot study, to determine whether treatment with 2000 international units of vitamin D3 daily for 3 months, would normalize the vitamin D levels in vitamin D deficient adolescents. Following treatment there was a 56.02% increase in the vitamin D levels from the mean baseline values and 80.39% of the subjects normalized their vitamin D levels. There were no adverse effects associated with this intervention. This study offers complementary guidelines to the existing recommendations from the American Academy of Pediatrics on the optimal dose and duration of vitamin D3 therapy in vitamin D deficient, but otherwise healthy adolescents. Further prospective, large scale, case control studies are indicated to validate our results.

Association between serum vitamin D levels and lipid profiles: a cross-sectional analysis

“…This finding is inconsistent with the study by Ponda et al, which demonstrated that an increase in vitamin D levels leads to an increase in HDL 23 . In the study by Kumaratne et al, high vitamin D levels were associated with a decrease in LDL, which is in line with the present study 19 . Additionally, the study by Asmi et al showed that LDL levels were lower in individuals without vitamin D deficiency compared to those with vitamin D deficiency 21 .…”

“…In the study by Faridi et al, it was also demonstrated that 15% of individuals had vitamin D deficiency, which was relevant to the current study 18 . Furthermore, in the study by Kumaratne et al, vitamin D levels were estimated to be below normal in 20% of individuals 19 . In the study conducted by Khoo et al, the vitamin D level was estimated to be below 20 ng/mL in 17% of individuals, which was within the scope of the present study 19 .…”

“…Furthermore, in the study by Kumaratne et al, vitamin D levels were estimated to be below normal in 20% of individuals 19 . In the study conducted by Khoo et al, the vitamin D level was estimated to be below 20 ng/mL in 17% of individuals, which was within the scope of the present study 19 . Upon reviewing foreign literature, it was found that the level of Vitamin D in Iran did not differ significantly from other countries 18 .…”