Treatments for spinal cord injury: Is there hope in neurosteroids?

Progesterone attenuates Aβ 25–35 -induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathway

“…Neuroprotective properties of neurosteroids have been reported in numerous studies [10,11]. Progesterone (PROG), beyond a vital role in maintaining pregnancy, has also been a neuroactive steroid.…”

Endogenous and Synthetic Neurosteroids in the Treatment of Niemann–Pick Type C Disease

“…These include neuroprotection against ischemia and stroke [58-64], recovery of motor function after spinal cord injury [65][66][67][68][69][70], regulation of myelination [13,19,[71][72][73][74][75][76], proliferation of neuronal stem cells [77,78], neurogenesis in the hippocampus [77][78][79][80][81][82], and induction of analgesia [83,84]. Many of these actions of neurosteroids are discussed in detail in other chapters of this book.…”

Progesterone receptor signalling in retinal photoreceptor neuroprotection

“…Steroid hormones and their metabolites in the central nervous system (CNS) are commonly thought of as neurosteroids (Baulieu ). Their neuroprotective properties have been defined in several different systems (Compagnone ; Borowicz et al . ).…”

“…Steroid hormones and their metabolites in the central nervous system (CNS) are commonly thought of as neurosteroids (Baulieu 1991). Their neuroprotective properties have been defined in several different systems (Compagnone 2008;Borowicz et al 2011). Progesterone is one of these neurosteroids, the effects of which are well-documented in many different experimental models of disease and neurodegeneration: spinal cord injury, brain ischaemia, stroke, Alzheimer's disease and perhaps most prominently, traumatic brain injury (Gonzalez Deniselle et al 2002a,b;Gonzalez et al 2005;Compagnone 2008;Espinosa-Garc ıa et al 2014;Yousuf et al 2014;Qin et al 2015).…”

“…Their neuroprotective properties have been defined in several different systems (Compagnone 2008;Borowicz et al 2011). Progesterone is one of these neurosteroids, the effects of which are well-documented in many different experimental models of disease and neurodegeneration: spinal cord injury, brain ischaemia, stroke, Alzheimer's disease and perhaps most prominently, traumatic brain injury (Gonzalez Deniselle et al 2002a,b;Gonzalez et al 2005;Compagnone 2008;Espinosa-Garc ıa et al 2014;Yousuf et al 2014;Qin et al 2015). Furthermore, studies highlighting its safety and viability in a number of different models of traumatic brain injury have ensured progesterone's entry into human clinical trials (Stein 2011(Stein , 2013Stein et al 2015).…”