Treatments in Neurology: The Winding Road from 1897 to 2022

Abstract

<b><i>Background:</i></b> For many years, neurology was seen as a purely observational discipline, focused on pathology and with little interest in treatments. <b><i>Summary:</i></b> From the creation in 1897 of <i>Monatsschrift für Psychiatrie und Neurologie</i>, the forebear of European Neurology, to nowadays, there have been great changes in the paradigms and concepts of treatments in neurology. We present an overview of the evolution of neurological treatments from 1897 to 2022. <b><i>Key Messages:</i></b> However, the last 125 years have not consisted of constant progress. The exceptional advances made in some diseases (multiple sclerosis or surgical treatment of Parkinson’s disease) cannot hide the stagnation in others (certain brain tumors or amyotrophic lateral sclerosis).

Novel Therapeutic Efficacy of Curcumin and Fish Oil (Omega-3 Fatty Acids) on Inhibiting Neuroinflammation and Neuronal Apoptosis via LPS Induction in BV-2 Cells

“…HT-22 cells incubated with 20-hr LPS-conditioned media showed a significant increase in the expression of the apoptosis marker Caspase 3/7 (13.17% of cells), as indicated by increased green dye fluorescent expression compared to control (1.22% of cells) (Figure 5). Conditioned media from the 50µM curcumin/100nM LPS or 0.05% fish oil/100 nM LPS condition showed significant reductions in Caspase 3/7 expression (7.25% and 8.13% respectively) in comparison to LPS (13.17%) [18].…”