Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study

Brandt, Piet A. van den; Nieuwenhuis, Lisette

doi:10.1007/s10552-017-0979-7

Cited by 19 publications

(7 citation statements)

References 38 publications

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“…Binding of phytoestrogens activates estrogen receptor-beta, thereby promoting apoptosis of colorectal cells ( 51 ). However, in previous analyses in the NLCS, we found no significant associations between nut intake and ovarian, endometrial or estrogen receptor-positive breast cancer ( 52 , 53 ). Lastly, the bowel transit time and frequency of constipation have been reported to be higher in women than in men ( 54 ).…”

Section: Discussioncontrasting

confidence: 71%

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nieuwenhuis¹,

Simons

Weijenberg

et al. 2020

Carcinogenesis

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Nut intake has been associated with reduced total cancer-related mortality, but evidence for colorectal cancer (CRC) risk is inconclusive. We investigated the associations between nut and peanut butter intake and anatomical CRC subtypes. To account for molecular heterogeneity, associations between nut and peanut butter intake and colorectal tumors harboring APC, KRAS, or BRAF mutations, p53 overexpression, or microsatellite instability were examined in secondary analyses. In the NLCS (n=120852), lifestyle habits were measured with a questionnaire in 1986. After 20.3 years follow-up, 3567 CRC cases were included in case-cohort analyses. For the analyses of molecular CRC subtypes, 574 cases were included after 7.3 years follow-up. In categorical analyses, total nut intake was not significantly associated with CRC (HR(95%CI) 10+ g/day versus nonconsumers=0.94(0.78-1.15) in men; 0.96(0.75-1.22) in women). In restricted cubic spline analyses, significant nonlinear inverse associations with rectal cancer were observed for total nut, peanut, and peanut butter intake in women, and borderline significant nonlinear inverse associations for total nut and peanut intake in men. Regarding the molecular CRC subtypes, peanut butter intake was significantly associated with an increased risk of colorectal tumors that did not develop through the serrated neoplasia pathway in men (HR(95%CI) per 5 g/day increment=1.22(1.07-1.38)). Nut and peanut butter intake are nonlinearly inversely associated with rectal cancer risk in women. In men, nut intake is borderline significantly nonlinearly associated with a reduced rectal cancer risk. Peanut butter is associated with an increased risk of colorectal tumors that do not develop through the serrated neoplasia pathway in men.

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Section: Discussioncontrasting

confidence: 71%

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nieuwenhuis¹,

Simons

Weijenberg

et al. 2020

Carcinogenesis

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“…All 3 dietary indices consist of dietary factors that have been independently associated with reduced breast cancer risk (although with varying degrees of evidence). All reward intake of fruits, vegetables, whole grains, and nuts and legumes, which have been associated with reduced risk of breast cancer, especially ER-breast cancer (5,(36)(37)(38). Proposed mechanisms for these associations include the antioxidant, anti-inflammatory, and immunological benefits of carotenoids (39-41) and flavonoids (42)(43)(44), as well as possible reductions in circulating estrogen and androstenedione levels with increasing fiber intake (45, 2 Among parous women.…”

Section: Discussionmentioning

confidence: 99%

Dietary index scores and invasive breast cancer risk among women with a family history of breast cancer

Petimar

Park

Smith‐Warner

et al. 2019

The American Journal of Clinical Nutrition

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Background Many epidemiologic studies have analyzed the relations of individual foods and nutrients and breast cancer risk with inconsistent results. Few studies have examined recommendation-based dietary indices and breast cancer risk. Objective The aim of this study was to determine associations between recommendation-based dietary index scores and incident invasive breast cancer. Methods The Sister Study is a prospective cohort of 50,884 US women (baseline: 2003–2009) who had a sister with breast cancer but no prior breast cancer themselves. We created scores for the Dietary Approaches to Stop Hypertension (DASH) diet, Alternative Mediterranean Diet (AMED), and Alternative Healthy Eating Index–2010 (AHEI-2010) from dietary intakes estimated by a baseline-validated Block food-frequency questionnaire (FFQ). We used Cox regression to estimate multivariable-adjusted HRs and 95% CIs for total invasive breast cancer risk and by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status. Results We documented 1,700 invasive breast cancer cases through 2015 (mean follow-up, 7.6 y). Individuals in the highest quartile of DASH scores had a lower risk of invasive breast cancer compared with those in the lowest quartile (HR: 0.78; 95% CI: 0.67, 0.90; P-trend = 0.001), with stronger associations for ER– (HR: 0.61; 95% CI: 0.40, 0.94; P-trend = 0.006) as well as ER–/PR– and ER–/PR–/HER2– subtypes. AHEI-2010 (HR for highest compared with lowest quartile: 0.90; 95% CI: 0.78, 1.03; P-trend = 0.15) and AMED (HR for highest compared with lowest quartile: 0.90; 95% CI: 0.77, 1.06; P-trend = 0.07) were weakly and nonsignificantly associated with breast cancer risk, but after excluding alcohol, AHEI-2010 was inversely associated with risk of ER–/PR– (HR: 0.64; 95% CI: 0.42, 0.98; P-trend = 0.04) and ER–/PR–/HER2– subtypes. We did not observe any significant interactions by menopausal status or other participant characteristics. Conclusions DASH scores were inversely associated with breast cancer risk; DASH and AHEI-2010 scores excluding alcohol were particularly inversely associated with risk of ER–/PR– and ER–/PR–/HER2– breast cancers. This trial was registered at clinicaltrials.gov as NCT00047970.

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“…A number of studies published in the last ten years have demonstrated the influence of nut consumption on cancer [91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107] (Table 5). Despite the fact that, in the observational studies, no causality could be proven, there were still several obvious strengths: prospective design for the majority of the studies, large population size, high retention rates with long-term follow-up, and adjustments for a multitude of other potential risk factors.…”

Section: Association Between Nuts and Cancermentioning

confidence: 99%

“…Several studies indicated that patients in the highest tree nut and peanut-intake group compared to the lowest intake group at any point in time during the study period were: 40%, 25%, and 14% less likely to die from total cancer, gastric noncardia adenocarcinoma, and lung cancer, respectively [16,97,98]. Also, they were 46%, 45%, and 47% less likely to die from esophageal squamous cell carcinoma, estrogen receptor negative breast cancer, and estrogen-progesterone receptor breast cancer, respectively [100,102]. Subjects having at least two servings of nuts per week had 0.68 times the risk of pancreatic cancer compared with subjects having nuts never or almost never [93].…”

Section: Association Between Nuts and Cancermentioning

confidence: 99%

Health Benefits of Nut Consumption in Middle-Aged and Elderly Population

et al. 2019

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Aging is considered the major risk factor for most chronic disorders. Oxidative stress and chronic inflammation are two major contributors for cellular senescence, downregulation of stress response pathways with a decrease of protective cellular activity and accumulation of cellular damage, leading in time to age-related diseases. This review investigated the most recent clinical trials and cohort studies published in the last ten years, which presented the influence of tree nut and peanut antioxidant diets in preventing or delaying age-related diseases in middle-aged and elderly subjects (≥55 years old). Tree nut and peanut ingestion has the possibility to influence blood lipid count, biochemical and anthropometric parameters, endothelial function and inflammatory biomarkers, thereby positively affecting cardiometabolic morbidity and mortality, cancers, and cognitive disorders, mainly through the nuts’ healthy lipid profile and antioxidant and anti-inflammatory mechanisms of actions. Clinical evidence and scientific findings demonstrate the importance of diets characterized by a high intake of nuts and emphasize their potential in preventing age-related diseases, validating the addition of tree nuts and peanuts in the diet of older adults. Therefore, increased consumption of bioactive antioxidant compounds from nuts clearly impacts many risk factors related to aging and can extend health span and lifespan.

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Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study

Cited by 19 publications

References 38 publications

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Dietary index scores and invasive breast cancer risk among women with a family history of breast cancer

Health Benefits of Nut Consumption in Middle-Aged and Elderly Population

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